Clinical Thyroidology / Case Report

Cavaco D.R.a· Alves Rafael A.b· Cabrera R.c· Vilar H.a· Leite V.a,d

Author affiliations

aDepartment of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
bDepartment of General Surgery, CUF Academic Center – Hospital CUF Sintra and Hospital CUF Cascais, Lisbon, Portugal
cDepartment of Pathology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
dNOVA Medical School/New University of Lisboa, Lisbon, Portugal

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Article / Publication Details

First-Page Preview

Received: March 13, 2021
Accepted: July 12, 2021
Published online: September 07, 2021

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 2235-0640 (Print)
eISSN: 2235-0802 (Online)

For additional information: https://www.karger.com/ETJ

Abstract

Diffuse thyroid lipomatosis is a rare histopathological condition of unknown etiology, characterized by diffuse fatty infiltration of the thyroid stroma, which can result in diffuse goiter with compressive symptoms. We report a case of a 46-year-old man with 1-year history of progressive goiter enlargement with compressive symptoms. Imaging studies revealed multiple coalescent nodules. The patient underwent surgery, and the microscopic appearance revealed a diffuse infiltration of thyroid stroma by mature adipose tissue with associated amyloid deposition. A final diagnosis of diffuse lipomatosis of the thyroid gland was established. This patient represents one of the few reported cases of diffuse lipomatosis with coexisting deposition of amyloid protein of the thyroid gland and contributes to the better understanding of this extremely rare condition.

© 2021 European Thyroid Association. Published by S. Karger AG, Basel

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First-Page Preview

Received: March 13, 2021
Accepted: July 12, 2021
Published online: September 07, 2021

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 2235-0640 (Print)
eISSN: 2235-0802 (Online)

For additional information: https://www.karger.com/ETJ

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