Abdelkader NF, Elyamany M, Gad AM, Assaf N, Fawzy HM, Elesawy WH (2020) Ellagic acid attenuates liver toxicity induced by valproic acid in rats. J Pharmacol Sci 143:23–29. https://doi.org/10.1016/j.jphs.2020.01.007

Article  CAS  PubMed  Google Scholar 

Almeida LF, dos Santos ECF, Machado JCB, de Oliveira AM, Napoleão TH, Ferreira MRA, Soares LAL (2023) Perfil fitoquímico, actividades in vitro y toxicidad de extractos optimizados de Eugenia uniflora. Bol Latinoam Caribe Plant Med Aromat 22:130–144. https://doi.org/10.37360/blacpma.23.22.1.10

Araújo NMP, Arruda HS, Dos Santos FN, de Morais DR, Pereira GA, Pastore GM (2020) LC - MS/MS screening and identification of bioactive compounds in leaves, pulp and seed from Eugenia calycina Cambess. Food Res Int 137:109556. https://doi.org/10.1016/j.foodres.2020.109556

Article  CAS  Google Scholar 

Araújo NMP, Arruda HS, de Paulo Farias D, Molina G, Pereira GA, Pastore GM (2021) Plants from the genus Eugenia as promising therapeutic agents for the management of diabetes mellitus: a review. Food Res Int 142:110182. https://doi.org/10.1016/j.foodres.2021.110182

Article  CAS  Google Scholar 

Assunção PID, da Conceição EC, Borges LL, de Paula JAM (2017) Development and validation of a HPLC-UV method for the evaluation of ellagic acid in liquid extracts of Eugenia uniflora L. (Myrtaceae) leaves and its ultrasound-assisted extraction optimization. Evid Based Complement Alternat Med 2017:1501038. https://doi.org/10.1155/2017/1501038

Article  CAS  PubMed  PubMed Central  Google Scholar 

Assunção PID, Paula JAM, Conceição EC, Devilla IA, Amaral VCS (2024) Processo de obtenção de extratos padronizados, secos por aspersão (spray drying), das folhas de Eugenia uniflora L. (Myrtaceae). BR Patent BR 10 2024 001668 8

Auricchio MT, Bugno A, Barros SBM, Bacchi EM (2007) Atividades antimicrobiana e antioxidante e toxicidade de Eugenia uniflora. Lat Am J Pharm 26:76–81

CAS  Google Scholar 

Bakr RO, Mohamed SA, Waly NE (2017) Phytochemical and biological investigation of Eugenia uniflora L. cultivated in Egypt. J Pharmacogn Phytother 9:57–66. https://doi.org/10.5897/JPP2017.0443

Article  CAS  Google Scholar 

Balarastaghi S, Delirrad M, Jafari A, Majidi M, Sadeghi M, Zare-Zardini H, Karimi G, Ghorani-Azam A (2022) Potential benefits versus hazards of herbal therapy during pregnancy; a systematic review of available literature. Phytother Res 36:824–841. https://doi.org/10.1002/ptr.7363

Article  PubMed  Google Scholar 

Bernstein N, Akram M, Yaniv-Bachrach Z, Daniyal M (2021) Is it safe to consume traditional medicinal plants during pregnancy? Phytother Res 35:1908–1924. https://doi.org/10.1002/ptr.6935

Article  CAS  PubMed  Google Scholar 

Bezerra ICF, Ramos RTDM, Ferreira MRA, Soares LAL (2018) Chromatographic profiles of extractives from leaves of Eugenia uniflora. Rev Bras Farmacogn 28:92–101. https://doi.org/10.1016/j.bjp.2017.11.002

Article  CAS  Google Scholar 

Bezerra ICF, Ramos RTDM, Ferreira MRA, Soares LAL (2020) Optimization strategy for extraction of active polyphenols from leaves of Eugenia uniflora Linn. Food Anal Methods 13:735–750. https://doi.org/10.1007/s12161-019-01691-5

Article  Google Scholar 

Brito WA, Ferreira MRA, Dantas DS, Soares LAL (2022) Biological activities of Eugenia uniflora L (pitangueira) extracts in oxitative stress-induced pathologies: a systematic review and meta-analysis of animal studies. Pharma Nutrition 20:100290. https://doi.org/10.1016/j.phanu.2022.100290

Article  CAS  Google Scholar 

Candeia GLOM, Costa WK, de Oliveira AM, Napoleão TH, GuedesPaiva PM, Ferreira MRA, Lira Soares LA (2022) Anti-inflammatory, antinociceptive effects and involvement of opioid receptors in the antinociceptive activity of Eugenia uniflora leaves obtained with water, ethanol, and propylene glycol mixture. J Ethnopharmacol 296:115508. https://doi.org/10.1016/j.jep.2022.115508

Article  CAS  Google Scholar 

Chernoff N, Rogers JM, Kavlock RJ (1989) An overview of maternal toxicity and prenatal development: considerations for developmental toxicity hazard assessments. Toxicology 59:111–125. https://doi.org/10.1016/0300-483x(89)90050-4

Article  CAS  PubMed  Google Scholar 

Chernoff N, Rogers EH, Gage MI, Francis BM (2008) The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the “no observed adverse effect level.” Reprod Toxicol 25:192–202. https://doi.org/10.1016/j.reprotox.2007.12.001

Article  CAS  PubMed  Google Scholar 

Chernoff N, Gage MI, Stoker TE, Cooper RL, Gilbert ME, Rogers EH (2009) Reproductive effects of maternal and pre-weaning undernutrition in rat offspring: age at puberty, onset of female reproductive senescence and intergenerational pup growth and viability. Reprod Toxicol 28:489–494. https://doi.org/10.1016/j.reprotox.2009.06.006

Article  CAS  PubMed  Google Scholar 

Cipriano RR, Maia BHLNS, Deschamps C (2021) Chemical variability of essencial oils of Eugenia uniflora L. genotypes and their antioxidant activity. Ann Acad Bras Cienc 93:e20181299. https://doi.org/10.1590/0001-3765202120181299

Article  CAS  Google Scholar 

Consolini AE, Sarubbio MG (2002) Pharmacological effects of Eugenia uniflora (Myrtaceae) aqueous crude extract on rat’s heart. J Ethnopharmacol 81:57–63. https://doi.org/10.1016/s0378-8741(02)00039-9

Article  PubMed  Google Scholar 

Costa BM, Mengal V, Brasil GA, Peluso AA, Treebak JT, Endlich PW, de Almeida SA, de Abreu GR (2022) Ellagic acid prevents myocardial infarction-induced left ventricular diastolic dysfunction in ovariectomized rats. J Nutr Biochem 105:108990. https://doi.org/10.1016/j.jnutbio.2022.108990

Article  CAS  PubMed  Google Scholar 

Damasceno DC, Kempinas WDG, Volpato GT, Consonni M, Rudge MVC, Paumgartten FJR (2008) Anomalias congênitas: estudos experimentais, 1st edn. Coopmed, Belo Horizonte, p 102 

de Santana BF, Voeks RA, Funch LS (2016) Ethnomedicinal survey of a maroon community in Brazil’s Atlantic tropical forest. J Ethnopharmacol 181:37–49. https://doi.org/10.1016/j.jep.2016.01.014

Article  PubMed  Google Scholar 

Desesso JM, Scialli AR (2018) Bone development in laboratory mammals used in developmental toxicity studies. Birth Defects Res 110:1157–1187. https://doi.org/10.1002/bdr2.1350

Article  CAS  PubMed  Google Scholar 

Durgun C, Asir F (2022) Effect of ellagic acid on damage caused by hepatic ischemia reperfusion in rats. Euro Rev Med Pharmacol Sci 26:8209–8215. https://doi.org/10.26355/eurrev_202211_30352

Article  CAS  Google Scholar 

Falcão TR, de Araújo AA, Soares LAL, de Moraes Ramos RT, Bezerra ICF, Ferreira MRA, de Souza Neto MA, Melo MCN, de Araújo RFJr, de Aguiar Guerra ACV, de Medeiros JS, Guerra GCB (2018) Crude extract and fractions from Eugenia uniflora Linn leaves showed anti-inflammatory, antioxidant, and antibacterial activities. BMC Complement Altern Med 18:84. https://doi.org/10.1186/s12906-018-2144-6

Ferreira MRA, Daniele-Silva A, de Almeida LF, Felipe Dos Santos EC, Barbosa Machado JC, Macário de Oliveira A, de Freitas Fernandes Pedrosa M, Guedes Paiva PM, Napoleão TH, Lira Soares LA (2022) Safety evaluation of aqueous extract from Eugenia uniflora leaves: Acute and subacute toxicity and genotoxicity in vivo assays. J Ethnopharmacol 298:115668. https://doi.org/10.1016/j.jep.2022.115668

Fleeman TL, Cappon GD, Chapin RE, Hurtt ME (2005) The effects of feed restriction during organogenesis on embryo-fetal development in the rat. Birth Defects Res B Dev Reprod Toxicol 74:442–449. https://doi.org/10.1002/bdrb.20056

Article  CAS  PubMed  Google Scholar 

García-Niño WR, Zazueta C (2015) Ellagic acid: pharmacological activities and molecular mechanisms involved in liver protection. Pharmacol Res 97:84–103. https://doi.org/10.1016/j.phrs.2015.04.008

Article  CAS  PubMed  Google Scholar 

Girardelo JR, Munari EL, Dallorsoleta JCS, Cechinel G, Goetten ALF, Sales LR, Reginatto FH, Chaves VC, Smaniotto FA, Somacal S, Emanuelli T, Benech JC, Soldi C, Winter E, Conterato GMM (2020) Bioactive compounds, antioxidant capacity and antitumoral activity of ethanolic extracts from fruits and seeds of Eugenia involucrata DC. Food Res Int 137:109615. https://doi.org/10.1016/j.foodres.2020.109615

Article  CAS  PubMed  Google Scholar 

González DM, Ritter MR, Konrath EL (2023) Medicinal plants for digestive disorders: a review of ethnobotanical studies conducted in southern Brazil. Bol Latinoam Caribe Plantas Med Aromat 22:770–795. https://doi.org/10.37360/blacpma.23.22.6.53

Article  Google Scholar 

Jesus ENS, Tavares MS, Barros PAC, Miller DC, da Silva PIC, Freitas JJS, de Lima AB, Setzer WN, da Silva JKR, Figueiredo PLB (2023) Chemical composition, antinociceptive and anti-inflammatory activities of the curzerene type essential oil of Eugenia uniflora from Brazil. J Ethnopharmacol 317:116859. https://doi.org/10.1016/j.jep.2023.116859

Article  CAS  PubMed  Google Scholar 

Kelly WL, Bryden MM (1983) A modified differential stain for cartilage and bone in whole mount preparations of mammalian fetuses and small vertebrates. Stain Technol 58:131–134. https://doi.org/10.3109/10520298309066773

Article  CAS  PubMed  Google Scholar 

Khera KS (1984) Maternal toxicity-a possible factor in fetal malformations in mice. Teratology 29:411–416. https://doi.org/10.1002/tera.1420290312

Article  CAS  PubMed  Google Scholar