Emergence of NEC features in corticotroph PitNETs: primary tumor, radiation-induced transformation, or metastasis?

WHO Classification of Tumours Editorial Board. WHO Classification of Tumours: Endocrine and Neuroendocrine Tumours. 5th ed. Lyon: IARC; 2022

Asa SL, Casar-Borota O, Chanson P, Danskin C, Delellis RA, Earls P et al (2017) From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal. Endocr Relat Cancer. 24(4):C5–C8. https://doi.org/10.1530/ERC-17-0004

Article  CAS  PubMed  Google Scholar 

WHO Classification of Tumours Editorial Board. WHO Classification of Tumours: Tumours of Endocrine Organs. 4th ed. Lyon: IARC; 2017

Mete O, Ezzat S, Asa SL (2018) Biomarkers of aggressive pituitary adenomas. J Clin Endocrinol Metab. 103(11):3874–3884. https://doi.org/10.1530/JME-12-0113

Article  CAS  Google Scholar 

Pease M, Ling C, Mackenzie-Feder J, Perry A, Mete O, Ezzat S et al (2020) TERT promoter mutations and ATRX loss in pituitary neuroendocrine tumors. Endocr Pathol. 31(2):136–144. https://doi.org/10.1007/s12022-020-09632-4

Article  Google Scholar 

Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA et al (2022) Overview of the 2022 WHO classification of neuroendocrine neoplasms. Endocr Pathol. 33(1):115–154. https://doi.org/10.1007/s12022-022-09708-2

Article  CAS  PubMed  Google Scholar 

Joseph NM, Umetsu SE, Kim GE, Tanas MR, O’Donnell R, Gill AJ et al (2024) Progression of low-grade neuroendocrine tumors (NET) to high-grade neoplasms harboring the NEC-like co-alteration of RB1 and TP53. Endocr Pathol. 35(4):325–337. https://doi.org/10.1007/s12022-024-09835-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kasajima A, Pfarr N, Mayr EM, Ura A, Moser E, von Werder A et al (2024) Rapid evolution of metastases in patients with treated G3 neuroendocrine tumors associated with NEC-like transformation and TP53 mutation. Endocr Pathol 35(4):313–324. https://doi.org/10.1007/s12022-024-09827-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanaan C, Bani MA, Ducreux M, Planchard D, Lamartina L, Moog S, Pudlarz T, Baudin E, Hadoux J, Al-Ghuzlan A, Scoazec JY (2025) Diagnostic relevance of p53 and Rb status in neuroendocrine tumors G3 from different organs: an immunohistochemical study of 465 high-grade neuroendocrine neoplasms. Virchows Arch 486(5):941–950. https://doi.org/10.1007/s00428-024-04006-0

Article  CAS  PubMed  Google Scholar 

Hamblin R, Vardon A, Akpalu J, Tampourlou M, Spiliotis I, Sbardella E et al (2022) Risk of second brain tumour after radiotherapy for pituitary adenoma or craniopharyngioma: a retrospective, multicentre, cohort study of 3679 patients with long-term imaging surveillance. Lancet Diabetes Endocrinol 10:581–88. https://doi.org/10.1016/S2213-8587(22)00160-7

Article  PubMed  Google Scholar 

Erridge SC, Conkey DS, Stockton D, Grant R, Kerr GR, Gregor A (2009) Radiotherapy for pituitary adenomas: long-term efficacy and toxicity. Radiother Oncol 93(3):597–601. https://doi.org/10.1016/j.radonc.2009.09.011

Article  PubMed  Google Scholar 

Ammar M, Coopmans EC, Gatto F, Franck SE, Janssen JAMJL, van der Lely AJ et al (2019) Pasireotide responsiveness in acromegaly is mainly driven by somatostatin receptor subtype 2 expression. J Clin Endocrinol Metab. 104(3):915–924. https://doi.org/10.1210/jc.2018-01524

Article  Google Scholar 

Gadelha MR, Wildemberg LE, Bronstein MD, Gatto F, Ferone D (2017) Somatostatin receptor ligands in the treatment of acromegaly. Pituitary 20(1):100–108. https://doi.org/10.1007/s11102-017-0791-0

Article  CAS  PubMed  Google Scholar 

Nishioka H, Inoshita N, Mete O, Asa SL, Hayashi K, Takeshita A et al (2015) The complementary role of transcription factors in the accurate diagnosis of clinically nonfunctioning pituitary adenomas. Endocr Pathol 26(4):349–355. https://doi.org/10.1007/s12022-015-9398-z

Article  CAS  PubMed  Google Scholar 

Inoshita N, Yoshimoto T, Takazawa Y, Noriaki F, Mitsuo O, Hiroshi N, Shozo Y (2023) Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs. Brain Tumor Pathol. 40(3):158–162. https://doi.org/10.1007/s10014-023-00442-2

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif