Treatment Strategies for Acute Exacerbation of Interstitial Lung Disease Associated with Systemic Autoimmune Rheumatic Diseases in Chinese Patients: A Scoping Review

Guiot J, Miedema J, Cordeiro A, et al. Practical guidance for the early recognition and follow-up of patients with connective tissue disease-related interstitial lung disease. Autoimmun Rev. 2024;23(6): 103582.

Article  CAS  PubMed  Google Scholar 

Zou Qinghua Lu, Yuewu ZJ, et al. Diagnosis and treatment protocol for connective tissue disease-associated interstitial lung disease. Chin J Internal Med. 2022;61(11):1217–23.

Google Scholar 

Kaul B, Cottin V, Collard HR, et al. Variability in global prevalence of interstitial lung disease. Front Med (Lausanne). 2021;8: 751181.

Article  PubMed  Google Scholar 

Ban C, Yan W, Xie B, et al. Spectrum of interstitial lung disease in China from 2000 to 2012. Eur Respir J. 2018;52(3):1701554.

Article  PubMed  Google Scholar 

Luppi F, Sebastiani M, Salvarani C, et al. Acute exacerbation of interstitial lung disease associated with rheumatic disease. Nat Rev Rheumatol. 2022;18(2):85–96.

Article  PubMed  Google Scholar 

Banuls L, Vanoverschelde J, Garnier F, et al. Interstitial lung disease worsens short- and long-term outcomes of systemic rheumatic disease patients admitted to the ICU: a multicenter study. J Clin Med. 2021;10(5):1037.

Article  PubMed  PubMed Central  Google Scholar 

Suzuki A, Kondoh Y, Brown KK, et al. Acute exacerbations of fibrotic interstitial lung diseases. Respirology. 2020;25(5):525–34.

Article  PubMed  Google Scholar 

Cerro Chiang G, Parimon T. Understanding interstitial lung diseases associated with connective tissue disease (CTD-ILD): genetics, cellular pathophysiology, and biologic drivers. Int J Mol Sci. 2023;24:2405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joy GM, Arbiv OA, Wong CK, Lok SD, Adderley NA, Dobosz KM, Johannson KA, Ryerson CJ. Prevalence, imaging patterns and risk factors of interstitial lung disease in connective tissue disease: a systematic review and meta-analysis. Eur Respir Rev. 2023;32:220210.

Article  PubMed  PubMed Central  Google Scholar 

Jee AS, Corte TJ. Current and emerging drug therapies for connective tissue disease-interstitial lung disease (CTD-ILD). Drugs. 2019;79:1511–28.

Article  PubMed  Google Scholar 

2022 guidelines for the diagnosis and treatment of connective tissue disease-associated interstitial lung disease

Yoo H, Hino T, Hwang J, et al. Connective tissue disease-related interstitial lung disease (CTD-ILD) and interstitial lung abnormality (ILA): evolving concept of CT findings, pathology and management. Eur J Radiol Open. 2022;9: 100419.

Article  PubMed  PubMed Central  Google Scholar 

Walsh SL, Sverzellati N, Devaraj A, Keir GJ, Wells AU, Hansell DM. Connective tissue disease related fibrotic lung disease: high resolution computed tomographic and pulmonary function indices as prognostic determinants. Thorax. 2014;69(3):216–22.

Article  PubMed  Google Scholar 

Marinescu DC, Hague CJ, Muller NL, et al. CT honeycombing and traction bronchiectasis extent independently predict survival across fibrotic interstitial lung disease subtypes. Radiology. 2025;314(2): e241001.

Article  PubMed  Google Scholar 

Spagnolo P, Distler O, Ryerson CJ, Tzouvelekis A, Lee JS, Bonella F, Bouros D, Hoffmann-Vold AM, Crestani B, Matteson EL. Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs). Ann Rheum Dis. 2021;80:143–50.

Article  CAS  PubMed  Google Scholar 

Oldham JM, Lee CT, Wu Z, Bowman, et al. Lung function trajectory in progressive fibrosing interstitial lung disease. Eur Respir J. 2022;59:2101396.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drakopanagiotakis F, Markart P, Steiropoulos P. Acute exacerbations of interstitial lung diseases: focus on biomarkers. Int J Mol Sci. 2023;24(12):10196.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishikawa G, Acquah SO, Salvatore M, et al. Elevated serum D-dimer level is associated with an increased risk of acute exacerbation in interstitial lung disease. Respir Med. 2017;128:78–84.

Article  PubMed  Google Scholar 

Zhang T, Shen P, Duan C, et al. KL-6 as an immunological biomarker predicts the severity, progression, acute exacerbation, and poor outcomes of interstitial lung disease: a systematic review and meta-analysis. Front Immunol. 2021;12: 745233.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akiyama M, Kaneko Y, Yamaoka K, et al. Association of disease activity with acute exacerbation of interstitial lung disease during tocilizumab treatment in patients with rheumatoid arthritis: a retrospective, case-control study. Rheumatol Int. 2016;36(6):881–9.

Article  CAS  PubMed  Google Scholar 

Cao H, Huan C, Wang Q, et al. Predicting survival across acute exacerbation of interstitial lung disease in patients with idiopathic inflammatory myositis: the GAP-ILD model. Rheumatol Ther. 2020;7(4):967–78.

Article  PubMed  PubMed Central  Google Scholar 

Xiaofei Z. Clinical characteristics and risk factor analysis of pulmonary infection in patients with connective tissue disease-associated interstitial lung disease. Guangzhou: Guangzhou Medical University; 2018.

Google Scholar 

Spagnolo P, Distler O, Ryerson CJ, et al. Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs). Ann Rheum Dis. 2021;80(2):143–50.

Article  CAS  PubMed  Google Scholar 

Juge PA, Borie R, Kannengiesser C, et al. Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis. Eur Respir J. 2017;49(5):1602314.

Article  PubMed  Google Scholar 

Akiyama M, Kaneko Y. Pathogenesis, clinical features, and treatment strategy for rheumatoid arthritis-associated interstitial lung disease. Autoimmun Rev. 2022;21(5):103056.

Article  CAS  PubMed  Google Scholar 

Liang J, Cao H, Ke Y, et al. Acute exacerbation of interstitial lung disease in adult patients with idiopathic inflammatory myopathies: a retrospective case-control study. Front Med (Lausanne). 2020;7:12.

Article  PubMed  Google Scholar 

Kim H, Cho SK, Song YJ, et al. Clinical characteristics of rheumatoid arthritis patients with interstitial lung disease: baseline data of a single-center prospective cohort. Arthritis Res Ther. 2023;25(1):43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McFarlane IM, Zhaz SY, Bhamra MS, et al. Assessment of interstitial lung disease among black rheumatoid arthritis patients. Clin Rheumatol. 2019;38(12):3413–24.

Article  PubMed  Google Scholar 

Respiratory Council of Chinese Research Hospital Association. Expert consensus on the management of interstitial lung disease during the COVID -19 epidemic. Zhonghua Jie He He Hu Xi Za Zhi. 2023;46(12):1204–18.

Google Scholar 

Mathai SC, Danoff SK. Management of interstitial lung disease associated with connective tissue disease. BMJ. 2016;352:6819.

Article  Google Scholar 

Chen HH, Yong YM, Lin CH, et al. Air pollutants and development of interstitial lung disease in patients with connective tissue disease: a population-based case-control study in Taiwan. BMJ Open. 2020;10(12):e041405.

Article  PubMed  PubMed Central  Google Scholar 

Qiaozhen Xu, Huixue Z, Huijuan H. Clinical characteristics and risk factors of pulmonary infection in patients with connective tissue disease-associated interstitial lung disease. Heilongjiang Med Pharm. 2024;37(2):390–3.

Google Scholar 

Shao T, Shi X, Yang S, et al. Interstitial lung disease in connective tissue disease: a common lesion with heterogeneous mechanisms and treatment considerations. Front Immunol. 2021;12: 684699.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gagiannis D, Steinestel J, Hackenbroch C, et al. Clinical, serological, and histopathological similarities between severe COVID-19 and acute exacerbation of connective tissue disease-associated interstitial lung disease (CTD-ILD). Front Immunol. 2020;11: 587517.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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