Instrumental thin-layer chromatography method for the simultaneous estimation of gabapentin and nortriptyline hydrochloride in tablet dosage form

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Indian Pharmacopeia (2010) Indian Pharmacopeial Commission, Ministry of Health and Family Welfare, Government of India, Ghaziabad, III, 1797

Indian Pharmacopeia (2018) Indian Pharmacopeial Commission, Ministry of Health and Family Welfare, Government of India, Ghaziabad, II, 2145

Harkhani H, Thummar K, Chauhan S, Vadalia J (2024) HPTLC method development and validation for the simultaneous estimation of nortriptyline HCl and pregabalin in their combined dosage form. J Chromatogr Sci 62:886–891. https://doi.org/10.1093/chromsci/bmad081

Article  CAS  PubMed  Google Scholar 

Shaikh S, Jain V (2018) Development and validation of novel RP-HPLC method for simultaneous estimation of gabapentin and amitriptyline hydrochloride in bulk and pharmaceutical dosage forms. Int J Appl Pharm 2:297–104. https://doi.org/10.22159/ijap.2018v10i2.24842

Article  CAS  Google Scholar 

Shah A, Kothari C, Patel N (2017) Concurrent estimation of gabapentin and nortriptyline hydrochloride in their combined dosage form using OPA-β-mercaptoethanol derivatization by spectrophotometric and spectrofluorimetric methods. Curr Pharm Anal 13:241–249

Article  CAS  Google Scholar 

Abhang MSR, Dhobale SM, Suryawanshi MAD, Jadhav SL, Patel SG (2019) Estimation of nortriptyline hydrochloride in bulk and formulation by UV-spectrophotometric area under curve method. J Drug Deliv Ther 9:147–150. https://doi.org/10.22270/jddt.v9i3.2628

Article  CAS  Google Scholar 

Soares S, Barroso M, Gallardo E (2021) A review of current bioanalytical approaches in sample pretreatment techniques for the determination of antidepressants in biological specimens. Rev Anal Chem 40:12–32. https://doi.org/10.1515/revac-2021-0124

Article  CAS  Google Scholar 

Mohamed FA, Bakr MF, Rageh AH, Mostafa AM (2016) The use of separation techniques in the analysis of some antiepileptic drugs: a critical review. J Liq Chromatogr Relat Technol 39:783–798. https://doi.org/10.1080/10826076.2016.1266654

Article  CAS  Google Scholar 

ALSaeedy M, Hasan A, Al-Adhreai A, Alrabie A, Qaba H, Mashrah A, Öncü-Kaya EM (2022) An overview of liquid chromatographic methods for analyzing new generation anti-epileptic drugs. J Liq Chromatogr Relat Technol 45:66–83. https://doi.org/10.1080/10826076.2022.2134146

Article  CAS  Google Scholar 

Naguib IA, Ali NA, Elroby FA, El Ghobashy MR, Abdallah FF (2020) US FDA-validated green GC–MS method for analysis of gabapentin, tramadol and/or amitriptyline mixtures in biological fluids. Bioanalysis 12:1521–1533. https://doi.org/10.4155/bio-2020-0217

Article  CAS  PubMed  Google Scholar 

Lin X, Cai Y, Yan J, Zhang L, Wu D, Li H (2015) Determination of gabapentin in human plasma and urine by capillary electrophoresis with laser-induced fluorescence detection. J Chromatogr Sci 53:986–992. https://doi.org/10.1093/chromsci/bmu134

Article  CAS  PubMed  Google Scholar 

Cao L, Liang S, Tan X, Meng J (2012) Determination of gabapentin in human plasma by capillary electrophoresis-laser induced fluorescence detection with and without solid-phase extraction. Microchim Acta 178:285–292. https://doi.org/10.1007/s00604-012-0835-0

Article  CAS  Google Scholar 

Ghogare JD, Panchal PP, Rathod SP, Jadhao UT (2023) Stability indicating HPTLC method development and validation for estimation of nortriptyline and pregabalin in tablet dosage form. AJPA 13:21–29. https://doi.org/10.52711/2231-5675.2023.00004

Article  Google Scholar 

Jain S, Solanki Y, Solanki A (2018) Development and validation of HPTLC methods for simultaneous estimation of gabapentin and amitriptyline hydrochloride in its marketed. Int J Pharm Res Med Plants 1:1–8

Google Scholar 

Bodiwala KB, Rana PM, Patel NT, Sureja DK, Gajjar AK (2021) Quantitation of ofloxacin, tinidazole, terbinafine hydrochloride, and clobetasol propionate in topical cream formulation by chromatographic methods. J Liq Chromatogr Relat Technol 44:329–341. https://doi.org/10.1080/10826076.2021.1930555

Article  CAS  Google Scholar 

Bodiwala KB, Banker N, Lalwani R, Shah MB, Gajjar AK (2024) Quality control methods for fruit extracts of Kigelia africana using high performance thin layer chromatography. Nat Prod Res 39(15):4409–4417. https://doi.org/10.1080/14786419.2024.2340762

Article  CAS  PubMed  Google Scholar 

Bagul TM, Patel HB, Mishra AD, Dedhiya PP, Bodiwala KB, Shah SA (2021) QbD-based simultaneous estimation of chlorpheniramine maleate, dextromethorphan hydrobromide and guaifenesin in its combined dosage form using high-performance thin-layer chromatographic method. Int J Pharm Biol Sci Arch 12(4):178–189

Google Scholar 

Bodiwala KB, Shah S, Thakor J, Marolia B, Prajapati P (2016) Degradation kinetics study of alogliptin benzoate in alkaline medium by validated stability-indicating HPTLC method. J AOAC Int 99:1505–1512. https://doi.org/10.5740/jaoacint.16-0120

Article  CAS  PubMed  Google Scholar 

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