Mahmoud Ali, Advocate HealthFollow
Dorota Magdon, Advocate HealthFollow
Abdulghani Mounir, Advocate HealthFollow
Lynn Erickson, Advocate HealthFollow
James Adefisoye, Advocate HealthFollow
Jim Kanani, Advocate HealthFollow
Andy Kieu, Advocate HealthFollow
Abdullah Malik, Advocate HealthFollow
Ali Ali, Mayo ClinicFollow
Nour Ghosoun, Mayo ClinicFollow
Jodi Zilinski, Advocate HealthFollow
Arshad Jahangir, Advocate HealthFollow
M. Eyman Mortada, Advocate HealthFollow
Imran Niazi, Advocate HealthFollow
Atul Bhatia, Advocate HealthFollow

Keywords

ablation, atrial fibrillation, cryoablation, laser balloon ablation

Abstract

Purpose: Atrial fibrillation (AF), the most common arrhythmia in older adults, is often treated with cryoballoon ablation (CBA) or laser balloon ablation (LBA) when refractory to medication. We used real-world patient data to investigate differences in arrhythmia-free survival, procedure and fluoroscopy times, and complications between these techniques.

Methods: In this single-center, retrospective study of 178 patients with symptomatic paroxysmal AF referred for first-time pulmonary vein isolation (PVI), 103 underwent CBA, and 75 underwent LBA. Recurrence was defined as any atrial arrhythmia of > 30 seconds’ duration after a three-month blanking period. Complications at 30 days were recorded. Kaplan-Meier analysis was used to estimate arrhythmia-free survival at one year for both groups. Categorical variables were expressed as n (%) and continuous variables as mean ± standard deviation or median (Q1, Q3).

Results: Baseline characteristics were similar between groups, with exception to left atrial volume index (CBA 32.2 ± 10.9 ml/m2; LBA 36.0 ± 11.0 ml/m2, p = 0.047). History of stroke was higher in CBA (13.6% vs 2.7%; p = 0.012), as was coronary artery disease (35.0% vs 14.7%, p = 0.002). Median fluoroscopy and procedure times (min) were significantly shorter in LBA (24.2 vs 31.6, p = 0.004; 141.0 vs 210.0, p

Conclusions: In patients with paroxysmal AF undergoing PVI, CBA and LBA were equally efficacious at one year and demonstrated acceptably low complication rates. LBA was associated with reduced procedure time and fluoroscopy exposure.

Recommended Citation

Ali M, Magdon D, Mounir A, et al. Comparative efficacy and safety of cryoballoon vs laser balloon ablation for pulmonary vein isolation in patients with paroxysmal atrial fibrillation. J Patient Cent Res Rev. 2025;12:106-112. 10.17294/2330-0698.2126

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