Gordon J, Kazemian H, Rohani S. MIL-53(Fe), MIL-101, and SBA-15 porous materials: potential platforms for drug delivery. Mater Sci Eng C. 2015;47:172–9. https://doi.org/10.1016/j.msec.2014.11.046.

Article  CAS  Google Scholar 

Vo AQ, Feng X, Morott JT, Pimparade MB, Tiwari RV, Zhang F, et al. A novel floating controlled release drug delivery system prepared by hot-melt extrusion. Eur J Pharm Biopharm. 2016;98:108–21. https://doi.org/10.1016/j.ejpb.2015.11.015.

Article  CAS  PubMed  Google Scholar 

Chamundeeswari M, Jeslin J, Verma ML. Nanocarriers for drug delivery applications. Environ Chem Lett. 2019;17:849–65. https://doi.org/10.1007/s10311-018-00841-1.

Article  CAS  Google Scholar 

Din F, Aman W, Ullah I, Qureshi OS, Mustapha O, Shafique S, et al. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomedicine. 2017;12:7291–309. https://doi.org/10.2147/IJN.S146315.

Article  PubMed  PubMed Central  Google Scholar 

Araujo RV, Santos SS, Ferreira EI, Giarolla J. New advances in general biomedical applications of PAMAM dendrimers. Molecules. 2018;23:1–27. https://doi.org/10.3390/molecules23112849.

Article  CAS  Google Scholar 

Gupta A, Dubey S, Mishra M. Unique structures, properties and applications of dendrimers. J Drug Deliv Ther. 2018;8:328–39. https://doi.org/10.22270/jddt.v8i6-s.2083.

Article  CAS  Google Scholar 

Magana N, Delia S, Vazquez-Lima H, Yepez R, Santillan R. Synthesis of frechet-type poly(aryl ether) dendrimers with allyl end groups: comparative convergent and divergent approaches. Arkivoc. 2017;5:117–28. https://doi.org/10.3998/ark.5550190.p009.994.

Article  Google Scholar 

Sandoval-Yanez C, Rodriguez CC. Dendrimers: amazing platforms for bioactive molecule delivery systems. Materials. 2020;13:1–20. https://doi.org/10.3390/ma13030570.

Article  CAS  Google Scholar 

• Santos A, Veiga F, Figueiras A. Dendrimers as pharmaceutical excipients: synthesis, properties, toxicity and biomedical applications. Materials. 2020;13:1–31. https://doi.org/10.3390/ma13010065This is a comprehensive review which highlights various synthesis methods, properties and applications of dendrimers as excipients in pharmacological formulations including biomedical applications.

Article  CAS  Google Scholar 

Guo L, Wang C, Yang C, Wang X, Zhang T, Zhang Z, et al. Morpholino-terminated dendrimer shows enhanced tumor pH-triggered cellular uptake, prolonged circulation time, and low cytotoxicity. Polymer. 2016;84:189–97. https://doi.org/10.1016/j.polymer.2015.12.056.

Article  CAS  Google Scholar 

Kumar PS, Datta MS, Kumar DM, Kumar TV, Krishna V, Ram D. Potential application of dendrimers in drug delivery: a concise review and update. J Drug Deliv Ther. 2016;6:71–88. https://doi.org/10.22270/jddt.v6i2.1195.

Article  CAS  Google Scholar 

Narmani A, Mohammadnejad J, Yavari K. Synthesis and evaluation of polyethylene glycol-and folic acid-conjugated -conjugated polyamidoamine G4 dendrimer as nanocarrier. J Drug Deliv Sci Technol. 2019;50:278–86. https://doi.org/10.1016/j.jddst.2019.01.037.

Article  CAS  Google Scholar 

Thanh VM, Nguyen TH, Tran TV, Ngoc UP, Ho MN, Nguyen TT, et al. Low systemic toxicity nanocarriers fabricated from heparin-mPEG and PAMAM dendrimers for controlled drug release. Mater Sci Eng C. 2018;82:291–8. https://doi.org/10.1016/j.msec.2017.07.051.

Article  CAS  Google Scholar 

Rabiee N, Ahmadvand S, Ahmadi S, Fatahi Y, Dinarvand R, Bagherzadeh M, et al. Carbosilane dendrimers: drug and gene delivery applications. J Drug Deliv Sci Technol. 2020;59:101879. https://doi.org/10.1016/j.jddst.2020.101879.

Article  CAS  Google Scholar 

Fan X, Zhang W, Hu Z, Li Z. Facile synthesis of RGD-conjugated unimolecular micelles based on a polyester dendrimer for targeting drug delivery. J Mater Chem B. 2017;5:1062–72. https://doi.org/10.1039/C6TB02234K.

Article  CAS  PubMed  Google Scholar 

Rai AK, Tiwari R, Maurya P, Yadav P. Dendrimers: a potential carrier for targeted drug delivery system. Pharm biol eval. 2016;3:257–87. https://doi.org/10.5281/zenodo.56068.

Article  Google Scholar 

Brunetti V, Bouchet LM, Strumia MC. Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems. Nanoscale. 2015;7:3808–16. https://doi.org/10.1039/C4NR04438J.

Article  CAS  PubMed  Google Scholar 

•• Dias AP, Santos SS, Silva JV, Parise-Filho R, Ferreira EI, Seoud OE, et al. Dendrimers in the context of nanomedicine. Int J Pharm. 2020;573:118814. https://doi.org/10.1016/j.ijpharm.2019.118814This review article provides in-detail description about dendrimers use in infectious diseases, cancer, neurological and information about available dendrimer products and in clinical phase.

Article  CAS  PubMed  Google Scholar 

Gorzkiewicz M, Janaszewska A, Ficker M, Svenningsen SW, Christensen JB, Klajnert-Maculewicz B. Pyrrolidone-modified PAMAM dendrimers enhance anti-inflammatory potential of indomethacin in vitro. Colloids Surf B: Biointerfaces. 2019;181:959–62. https://doi.org/10.1016/j.colsurfb.2019.06.056.

Article  CAS  PubMed  Google Scholar 

Ganda IS, Zhong Q, Hali M, Albuquerque RLC, Padilha FF, da Rocha SRP, et al. Dendrimer-conjugated peptide vaccine enhances clearance of Chlamydia trachomatis genital infection. Int J Pharm. 2017;527:79–91. https://doi.org/10.1016/j.ijpharm.2017.05.045.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stolarska M, Gucwa K, Urbanczyk-Lipowska Z, Andruszkiewicz R. Peptide dendrimers as antifungal agents and carriers for potential antifungal agent–N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic acid–synthesis and antimicrobial activity. J Pept Sci. 2020;26:1–7. https://doi.org/10.1002/psc.3226.

Article  CAS  Google Scholar 

Li N, Cai H, Jiang L, Hu J, Bains A, Hu J, et al. Enzyme-sensitive and amphiphilic PEGylated dendrimer-paclitaxel prodrug-based nanoparticles for enhanced stability and anticancer efficacy. ACS Appl Mater Interfaces. 2017;9:6865–77. https://doi.org/10.1021/acsami.6b15505.

Article  CAS  PubMed  Google Scholar 

• Sahoo RK, Gothwal A, Rani S, Nakhate KT, Gupta AU. PEGylated dendrimer mediated delivery of Bortezomib: drug conjugation versus encapsulation. Int J Pharm. 2020;584:119389–402. https://doi.org/10.1016/j.ijpharm.2020.119389This study reported the difference between conjugation and encapsulation of the drug Bortezomib to PAMAM dendrimer.

Article  CAS  PubMed  Google Scholar 

Singh J, Jain K, Mishra NK, Jain NK. Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers. Artif Cell Nanomed B. 2016;44:1626–34. https://doi.org/10.3109/21691401.2015.1129625.

Article  CAS  Google Scholar 

Wang J, Li D, Fan Y, Shi M, Yang Y, Wang L, et al. Core–shell tecto dendrimers formed via host–guest supramolecular assembly as pH-responsive intelligent carriers for enhanced anticancer drug delivery. Nanoscale. 2019;11:22343–50. https://doi.org/10.1039/C9NR08309J.

Article  CAS  PubMed  Google Scholar 

Abedi-Gaballu F, Dehghan G, Ghaffari M, Yekta R, Abbaspour-Ravasjani S, Baradaran B, et al. PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy. Appl Mater Today. 2018;12:177–90. https://doi.org/10.1016/j.apmt.2018.05.002.

Article  PubMed  PubMed Central  Google Scholar 

Bono N, Pennetta C, Bellucci M, Sganappa A, Malloggi C, Tadeschi G, et al. Role of generation on successful DNA delivery of PAMAM–(Guanidino)Neomycin conjugates. ACS Omega. 2019;4:6796–807. https://doi.org/10.1021/acsomega.8b02757.

Article  CAS  Google Scholar 

Somani S, Laskar P, Altwaijry N, Kewcharoenvong P, Irving C, Robb G, et al. PEGylation of polypropylenimine dendrimers: effects on cytotoxicity, DNA condensation, gene delivery and expression in cancer cells. Sci Rep. 2018;8:9410–23. https://doi.org/10.1038/s41598-018-27400-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weregowska-Ciecwierz K, Wisniewski M, Terzyk AP, Furmaniak S. The chemistry of bioconjugation in nanoparticles-based drug delivery system. Adv Cond Matter Phys. 2015;2015:1–28. https://doi.org/10.1155/2015/198175.

Article  Google Scholar 

Singh AK, Gothwal A, Rani S, Rana M, Sharma AK, Yadav AK, et al. Dendrimer donepezil conjugates for improved brain delivery and better in vivo pharmacokinetics. ACS Omega. 2019;4:4519–29. https://doi.org/10.1021/acsomega.8b03445.

Article