Global, regional, and national burden of diabetes from. to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 1990;402(10397):03–234.

Google Scholar 

Afkarian M, Zelnick LR, Hall YN, Heagerty PJ, Tuttle K, Weiss NS, de Boer IH. Clinical manifestations of kidney disease among US adults with diabetes, 1988–2014. JAMA. 2016;316(6):602–10.

PubMed  PubMed Central  Google Scholar 

Ahlqvist E, Storm P, Käräjämäki A, Martinell M, Dorkhan M, Carlsson A, Vikman P, Prasad RB, Aly DM, Almgren P, Wessman Y, Shaat N, Spégel P, Mulder H, Lindholm E, Melander O, Hansson O, Malmqvist U, Lernmark Å, Lahti K, Forsén T, Tuomi T, Rosengren AH, Groop L. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 2018;6(5):361–9.

PubMed  Google Scholar 

Almonte-Baldonado R, Bravo-Nuevo A, Gerald D, Benjamin LE, Prendergast GC, Laury-Kleintop LD. Rhob antibody alters retinal vascularization in models of murine retinopathy. J Cell Biochem. 2019;120(6):9381–91.

CAS  PubMed  Google Scholar 

Bachmann K, Wang TJ. Biomarkers of cardiovascular disease: contributions to risk prediction in individuals with diabetes. Diabetologia. 2017. https://doi.org/10.1007/s00125-017-4442-9.

PubMed  PubMed Central  Google Scholar 

Blanchet L, Vitale R, van Vorstenbosch R, Stavropoulos G, Pender J, Jonkers D, Schooten FV, Smolinska A. Constructing bi-plots for random forest: tutorial. Anal Chim Acta. 2020;1131:146–55.

CAS  PubMed  Google Scholar 

Bloomgarden ZT. Diabetic nephropathy. Diabetes Care. 2005;28(3):745–51.

PubMed  Google Scholar 

Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615–25.

CAS  PubMed  Google Scholar 

Brunelle JK, Santore MT, Budinger GRS, Tang Y, Barrett TA, Zong WX, Kandel E, Keith B, Simon MC, Thompson CB, Hay N, Chandel NS. C-myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of P53 and hypoxia-inducible factor-1. J Biol Chem. 2004. https://doi.org/10.1074/jbc.M312241200.

PubMed  Google Scholar 

Callaghan BC, Price RS, Feldman EL. Distal symmetric polyneuropathy: a review. JAMA. 2015;314(20):2172–81.

CAS  PubMed  PubMed Central  Google Scholar 

Campagnoli MF, Ramenghi U, Armiraglio M, Quarello P, Garelli E, Carando A, Avondo F, Pavesi E, Fribourg S, Gleizes PE, Loreni F, Dianzani I. RPS19 mutations in patients with Diamond-Blackfan anemia. Hum Mutat. 2008;29(7):911–20.

CAS  PubMed  Google Scholar 

Chang R, Jang CJH, Branco-Price C, Nghiem PP, Bailey-Serres J. Transient MPK6 activation in response to oxygen deprivation and reoxygenation is mediated by mitochondria and aids seedling survival in Arabidopsis. Plant Mol Biol. 2011. https://doi.org/10.1007/s11103-011-9850-5.

PubMed  Google Scholar 

Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–36.

PubMed  Google Scholar 

Choudhury D, Tuncel M, Levi M. Diabetic nephropathy – a multifaceted target of new therapies. Discov Med. 2010;10(54):406–15.

PubMed  Google Scholar 

Clark K, Peggie M, Plater L, Sorcek RJ, Young ER, Madwed JB, Hough J, McIver EG, Cohen P. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011;434(1):93–104.

CAS  PubMed  Google Scholar 

Clark K, Takeuchi O, Akira S, Cohen P. The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling. Proc Natl Acad Sci U S A. 2011. https://doi.org/10.1073/pnas.1114194108.

PubMed  PubMed Central  Google Scholar 

Congdon NG, Friedman DS, Lietman T. Important causes of visual impairment in the world today. JAMA. 2003;290(15):2057–60.

CAS  PubMed  Google Scholar 

Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, Federici M, Filippatos G, Grobbee DE, Hansen TB, Huikuri HV, Johansson I, Jüni P, Lettino M, Marx N, Mellbin LG, Östgren CJ, Rocca B, Roffi M, Sattar N, Seferović PM, Sousa-Uva M, Valensi P, Wheeler DC. 2019 ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41(2):255–323.

PubMed  Google Scholar 

Daruich A, Matet A, Moulin A, Kowalczuk L, Nicolas M, Sellam A, Rothschild PR, Omri S, Gélizé E, Jonet L, Delaunay K, De Kozak Y, Berdugo M, Zhao M, Crisanti P, Behar-Cohen F. Mechanisms of macular edema: beyond the surface. Prog Retin Eye Res. 2018;63:20–68.

PubMed  Google Scholar 

Di Angelantonio E, Kaptoge S, Wormser D, Willeit P, Butterworth AS, Bansal N, O’Keeffe LM, Gao P, Wood AM, Burgess S, Freitag DF, Pennells L, Peters SA, Hart CL, Håheim LL, Gillum RF, Nordestgaard BG, Psaty BM, Yeap BB, Knuiman MW, Nietert PJ, Kauhanen J, Salonen JT, Kuller LH, Simons LA, van der Schouw YT, Barrett-Connor E, Selmer R, Crespo CJ, Rodriguez B, Verschuren WM, Salomaa V, Svärdsudd K, van der Harst P, Björkelund C, Wilhelmsen L, Wallace RB, Brenner H, Amouyel P, Barr EL, Iso H, Onat A, Trevisan M, D’Agostino RB Sr., Cooper C, Kavousi M, Welin L, Roussel R, Hu FB, Sato S, Davidson KW, Howard BV, Leening MJ, Leening M, Rosengren A, Dörr M, Deeg DJ, Kiechl S, Stehouwer CD, Nissinen A, Giampaoli S, Donfrancesco C, Kromhout D, Price JF, Peters A, Meade TW, Casiglia E, Lawlor DA, Gallacher J, Nagel D, Franco OH, Assmann G, Dagenais GR, Jukema JW, Sundström J, Woodward M, Brunner EJ, Khaw KT, Wareham NJ, Whitsel EA, Njølstad I, Hedblad B, Wassertheil-Smoller S, Engström G, Rosamond WD, Selvin E, Sattar N, Thompson SG, Danesh J. Association of cardiometabolic multimorbidity with mortality. JAMA. 2015;314(1):52–60.

PubMed  Google Scholar 

Dyck PJ, Giannini C. Pathologic alterations in the diabetic neuropathies of humans: a review. J Neuropathol Exp Neurol. 1996;55(12):1181–93.

CAS  PubMed  Google Scholar 

Farrar JE, Dahl N. Untangling the phenotypic heterogeneity of Diamond Blackfan anemia. Semin Hematol. 2011;48(2):124–35.

CAS  PubMed  PubMed Central  Google Scholar 

Feldman EL, Nave KA, Jensen TS, Bennett DLH. New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain. Neuron. 2017;93(6):1296–313.

CAS  PubMed  PubMed Central  Google Scholar 

Fox CS, Sullivan LM, D’Agostino RB, Wilson PW. The significant effect of diabetes duration on coronary heart disease mortality. Diabetes Care. 2004. https://doi.org/10.2337/diacare.27.3.704.

PubMed  Google Scholar 

Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010;107(9):1058–70.

CAS  PubMed  PubMed Central  Google Scholar 

Greener JG, Kandathil SM, Moffat L, Jones DT. A guide to machine learning for biologists. Nat Rev Mol Cell Biol. 2022;23(1):40–55.

CAS  PubMed  Google Scholar 

Hashemi E, Dehghanbanadaki H, Baharanchi AA, Forouzanfar K, Kakaei A, Mohammadi SM, Zeidi S, Razi F. WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy. J Transl Med. 2021;19(1):299.

CAS  PubMed  PubMed Central  Google Scholar 

Heynen SR, Ogunshola OO, Grimm C. A brief account of rho GTPases in retinal physiology and pathophysiology. Adv Exp Med Biol. 2012;723:581–7.

CAS  PubMed  Google Scholar 

Huang J, Zhou Q. Gene biomarkers related to Th17 cells in macular edema of diabetic retinopathy: cutting-edge comprehensive bioinformatics analysis and in vivo validation. Front Immunol. 2022;13: 858972.

CAS  PubMed  PubMed Central  Google Scholar 

Imami K, Milek M, Bogdanow B, Yasuda T, Kastelic N, Zauber H, Ishihama Y, Landthaler M, Selbach M. Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis. Mol Cell. 2018;72(1):84–98.

CAS  PubMed  Google Scholar 

Izzedine H, Bodaghi B, Launay-Vacher V, Deray G. Eye and kidney: from clinical findings to genetic explanations. J Am Soc Nephrol. 2003;14(2):516–29.

PubMed  Google Scholar 

Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. Lancet. 2021;398(10302):786–802.

CAS  PubMed  Google Scholar 

Kawagoe T, Takeuchi O, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S. TANK is a negative regulator of toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol. 2009. https://doi.org/10.1038/ni.1771.

PubMed  PubMed Central  Google Scholar 

Kengne AP, Amoah A, Mbanya JC. Cardiovascular complications of diabetes mellitus in sub-saharan Africa. Circulation. 2005. https://doi.org/10.1161/CIRCULATIONAHA.105.544312.

PubMed  Google Scholar 

Kroll P, Rodrigues EB, Hoerle S. Pathogenesis and classification of proliferative diabetic vitreoretinopathy. Ophthalmologica. 2007;221(2):78–94.

PubMed  Google Scholar 

Li YJ, Chen X, Kwan TK, Loh YW, Singer J, Liu Y, Ma J, Tan J, Macia L, Mackay CR, Chadban SJ, Wu H. Dietary fiber protects against diabetic nephropathy through short-chain fatty acid-mediated activation of G protein-coupled receptors GPR43 and GPR109A. J Am Soc Nephrol. 2020;31(6):1267–81.

CAS  PubMed  PubMed Central