Authors Adelina Horhat Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Institut Mondor de Recherche Biomédicale, MINT-HEP Mondor Integrative Hepatology, Université Paris Est Créteil, Créteil, France Camelia Alexandra Coada Department of Morpho-functional sciences, University of Medicine and Pharmacy „Iuliu Hațieganu”, Cluj-Napoca, Romania Mina Dana Ignat Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca; Liver Unit, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania Petra Fischer Liver Unit, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania Zeno Adrian Sparchez 1. Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. 4. Liver Unit, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania. Bogdan Procopet Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca; Liver Unit, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania Horia Stefanescu Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca; Liver Unit, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania Zeno Sparchez Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca; Liver Unit, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania DOI: https://doi.org/10.15403/jgld-6214 Keywords: alcoholic hepatitis, biomarkers, infections, ingle nucleotide polymorphisms, cluster of differentiation 14 Abstract

Background and Aims: Severe alcoholic hepatitis is characterized by an increased risk of infections. Polymorphisms in immune response-related genes may influence susceptibility to infections in alcoholic hepatitis. This study aimed to investigate the association between two clusters of differentiation 14’s (CD14) single nucleotide polymorphisms (SNPs), rs2569190 and rs5744455, and the occurrence of infections in severe alcoholic hepatitis, the response to corticotherapy and the mortality rates at one and three months.

Methods: Patients with severe alcoholic hepatitis were genotyped for CD14 - rs2569190 and rs5744455 SNPs. Genotype and allele frequencies were compared between patients who presented infections and those who did not.

Results: A total of 97 patients with biopsy proven sAH were included in the study, out of which 47 (48.4 %) had an associated infection. rs5744455 SNP was significantly associated with the presence of infection. Patients carrying the rs5744455T variant allele had a lower incidence of infections compared to those with the wild-type allele (32% vs 68%; p=0.002). In contrast, the rs2569190 SNP revealed no significant differences, either in the single genotype analysis (p=0.608) or under a dominant model (p=0.318). Community-acquired infections were primarily urinary tract infections (21.65%), followed by pulmonary infections (4.12%), with Escherichia coli responsible for 41.67% of cases. Healthcare-associated infections were more varied, including urinary tract (7.22%), respiratory (6.19%), digestive (7.21%), cutaneous (3.09%), and blood infections (5.15%). Klebsiella pneumoniae was the most prevalent strain, accounting for 16.67% of these infections.

Conclusions: Our findings highlight a potential protective role of the CD14 rs5744455T variant allele against infections in sAH, suggesting that genetic variability may influence infection susceptibility in this population.

How to Cite

1.

Horhat A, Coada CA, Ignat MD, Fischer P, Sparchez ZA, Procopet B, Stefanescu H, Sparchez Z. Association of Single Nucleotide Polymorphisms with Infection Susceptibility in Patients with Severe Alcoholic Hepatitis. JGLD [Internet]. 2025 Aug. 22 [cited 2025 Aug. 22];. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/6214

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