In recent years, skin infections have historically increased in the global population owing to a variety of perilous microorganisms [1]. Accordingly, infectious diseases of the skin pose a critical threat to humankind. According to research, between 30 % and 70 % of the world's population suffers from skin infections [2]. Moreover, Flohr and Hay revealed that one-third of the world's population is suffering from skin diseases [3]. According to published data, skin infections rank as the fourth leading cause of human disease [2]. Unfortunately, it places additional strain on the healthcare systems of countries [1]. In brief, infectious diseases are caused by countless pathogens, including bacteria [4], viruses, parasites, fungi [5], and others. In short, it includes dermatophytosis, cutaneous leishmaniasis, cellulites, impetigo, acne, erysipelas, warts, molluscum contagiosum, herpes simplex, scabies, and other skin-related infections. Crucially, the primary causes of these infections are parasitic pathogens (Leishmania sp., Sarcoptes scabiei mites), fungi (dermatophytes and candida), viruses (human papillomavirus, herpes simplex virus, and molluscum contagiosum virus), bacteria [Streptococcus pyogenes, Staphylococcus epidermidis, Propionibacterium acnes, and Staphylococcus aureus (S. aureus)], and other pathogens [6]. According to research, there are around 3000 skin illnesses that may be separated into acute and chronic problems [7,8]. Here, people of various ages and socioeconomic backgrounds may be impacted by these skin issues [2]. The aged population is more vulnerable to certain skin diseases. In this case, it could produce countless symptoms in addition to unusual indicators. Furthermore, skin diseases can expand into chronic diseases and complete pre-existing chronic disorders [5]. Despite significant advances in biomedical research, effective and timely treatment options for skin infections remain lacking. As a result, the physical and physiological health of patients has been adversely affected by the ongoing rise in the prevalence of cutaneous infectious diseases [6]. Skin diseases are among the leading causes of morbidity worldwide. However, in several nations, while the importance of diverse policies and health planning has been recognized, it has often received limited attention [1]. In most cases of skin infections, the skin is unable to simultaneously repair itself and defend against pathogenic bacteria. Interestingly, the use of biomolecules in therapy offers a novel approach to address this challenge [5]. Some topical and oral anti-infectives have been advanced to treat infectious diseases of the skin [6]. More precisely, antimicrobial peptides, antibiotics [9], and natural extracts [10] have been developed to effectively treat skin infectious diseases. These substances can regulate the evolution of countless skin infectious diseases by preventing the spread of pathogenic microorganisms that cause disease [5]. Unfortunately, the primary barriers that give rise to hurdles like low patient compliance and poor therapeutic efficacy are high cost, inconvenience, lack of raw materials, low transdermal potential, low water solubility, low bioavailability, systemic toxicity, manufacturing quality issues, high drug resistance, adverse dose–response effects, etc. [6]. Additionally, numerous factors, such as the type of pathogen causing the infection and the layers of the skin involved, can influence the clinical manifestation of skin disorders. Moreover, the affected structures and the patient's overall health condition also play a significant role [11]. A comprehensive understanding of these factors is crucial to achieving optimal therapeutic outcomes and offering an effective alternative for the management of infectious skin diseases.

In recent years, the scientific community has increasingly focused on the growing preference for transdermal drug delivery methods to treat various health conditions [12,13]. This versatile technology enables targeted delivery of therapeutic agents to the desired area through the skin, whether for local or systemic applications [14]. Fortunately, it is the best substitute for oral administration [15]. Herein, it has several advantages, such as avoiding gastrointestinal and first-pass metabolisms [16], and overcoming inadequate oral absorption [17]. Unfortunately, the foremost hindrance to transdermal medication distribution that restricts its use for efficient disease therapy is the stratum corneum [14,18]. Transdermal drug delivery has advanced to a point where it may now precisely deliver therapeutic molecules to the desired spot for a therapeutic response without overcoming skin barriers [16,19]. In this instance, colloidal drug delivery methods are an improved preference for topical (such as cutaneous) [20] and transdermal delivery of drugs [21]. A wide range of colloidal drug delivery systems have been developed for the administration of therapeutically active molecules, including vitamins, medications, and nutraceuticals [22]. In a concise, the lipid-based and biopolymer-based carriers are the two categories of colloidal drug delivery systems [23]. Herein, plenty of nanosized formulations have been documented as components of colloidal drug delivery systems for the delivery of therapeutically active molecules [24]. These incorporate polymeric nanoparticles, self-nanoemulsifying drug delivery systems, nanoemulsion, phytosomes, microspheres, niosomes, liposomes [25], solid lipid nanoparticles, proteineous nanoparticles [26], nanostructured lipid carriers, self-dispersing lipid formulations, polymeric micelles, polysaccharide-protein particles [23], etc. Colloidal drug delivery systems offer numerous benefits, including enhanced stability, solubility, penetration, dissolution, and bioavailability. Additionally, they provide modified release, reduced toxicity, and protection against degradation caused by various factors, such as enzymatic breakdown [25]. Moreover, the use of hybrid nutraceutical-based self-assembled colloidal drug delivery systems enables the administration of hydrophobic pharmaceuticals, enhancing their dissolution, permeability, solubility, and therapeutic response. Additionally, this approach offers the potential to protect therapeutic molecules from degradation in the challenging environment of the gastrointestinal system [27]. As a result, we have provided a concise review of colloidal drug delivery techniques for treating infectious skin diseases in this review paper.