Worldwide, infectious illnesses caused by bacteria, viruses, and fungi continue to be a major health concern, necessitating improved medicine delivery methods [1]. It is frequently ineffective to administer medications orally or intravenously using the conventional procedures [2]. They may cause systemic toxicity, cause poor absorption, and render bacteria resistant to medications [3]. A kinder alternative is to inject medications via the skin. It does not break down in the liver first, allowing medications to escape [4]. However, many medications cannot pass through the stratum corneum, the top layer of the skin. Nanotechnology has shown promise in improving the way medications travel through the skin [5]. Drugs can pass through the skin, remain stable, and reach the appropriate locations with the aid of nano carriers consisting of lipids, polymers, metals, or molecules like trees [6]. Drugs may be released gradually, function better, and have less adverse effects throughout the body thanks to these microscopic transporters [7]. They are therefore excellent in curing bacterial illnesses. Notwithstanding their potential, transdermal systems improved by nanotechnology encounter problems. These include regulatory barriers and concerns regarding stability and potential harmful impacts. More research is required to improve nanoparticle formulations, increase medication penetration through the skin, and ensure clinical safety. In order to combat infectious illnesses, this paper examines how nanotechnology aids in the delivery of medications via the skin. It highlights important nanocarriers, their functions, applications, challenges, and potential future directions.