Volume 89, October 2025, 155155Author links open overlay panel, , , , , Section snippetsRegarding the analysis of response variables and relevant physiological covariates

In response to the comments concerning the inclusion of physiological data and potential confounding covariates, we consider it pertinent to present complementary information that was systematically recorded during the clinical evolution of the patients.

First, as previously shown in Fig. 1, patients presented with significant hypercapnia at the initiation of ECCO₂R support. This progression was accompanied by the maintenance of tidal volumes adjusted to Predicted Body Weight (PBW), approaching

Economic considerations and the Latin American context

We acknowledge the relevance of the comment regarding the costs associated with extracorporeal technologies such as ECCO₂R. Indeed, compared to conventional mechanical ventilation, this strategy represents a significant investment in terms of technological and logistical resources. However, it is essential to contextualize its use in a cohort composed of patients with moderate to severe ARDS who failed to respond to standard interventions (neuromuscular blockade, prone positioning, fluid

CRediT authorship contribution statement

Luis Alexander Peña-López: Conceptualization, Formal analysis, Writing – review & editing. Héctor Fabio Londoño Arcila: Formal analysis. Oscar Humberto Ruiz Serna: Writing – review & editing. Wilson Mauricio Lozano Franco: Writing – review & editing. Henry Mauricio Parada-Gereda: Writing – original draft. David Andrés Ballesteros Castro: Writing – review & editing.

Funding

This study did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Declaration of competing interest

The authors declare that they have no financial conflicts of interest that could have influenced the work presented in this manuscript.

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