Trends and future directions in chronic rhinosinusitis with nasal polyps: A bibliometric analysis

Brazilian Journal of OtorhinolaryngologyVolume 91, Issue 5, September–October 2025, 101672Brazilian Journal of OtorhinolaryngologyAuthor links open overlay panel, , , , , , Highlights•

CRSwNP significantly impairs patients' quality of life.

Study analyzes publications from 2004 to 2024.

United States leads in publication volume.

Key themes: inflammation, biologics, and surgery.

Future focus on safety and precision medicine.

AbstractObjectives

Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a complex inflammatory condition that significantly impairs patients’ quality of life. Despite significant efforts to develop effective treatments, a comprehensive bibliometric analysis in this field is lacking. This study aims to identify key trends, influential publications, leading authors, and collaborative networks.

Methods

A bibliometric analysis was conducted on October 16, 2024, examining publications in the Web of Science Core Collection (WoSCC) database from 2004 to 2024. Data visualization and interpretation were performed using VOSviewer (version 1.6.20), CiteSpace (version 6.3.R1), and R 4.3.3.

Results

The analysis included 1,235 publications from 5,825 authors across 4,723 institutions in 222 countries. The United States led in publication volume, followed by China and Italy. Major institutional contributors included Capital Medical University and Sanofi. The International Forum of Allergy & Rhinology published the most articles, while the Journal of Allergy and Clinical Immunology had the highest citation count. Key authors identified were Bachert Claus and Gevaert Philippe. Keyword analysis revealed “asthma”, “endoscopic sinus surgery”, and “inflammation” as dominant themes, with burst analysis indicating growing interest in “humanization”, “type 2 inflammation”, “risk”, “biologics”, and “safety”.

Conclusion

This bibliometric analysis underscores an increasing focus on biologic therapies, inflammation management, and endoscopic sinus surgery in CRSwNP research. Future investigations are likely to prioritize the long-term safety and cost-effectiveness of biologics, alongside advancements in precision medicine and surgical techniques.

Level of evidence

Level 1.

Keywords

Chronic rhinosinusitis with nasal polyps

Biologic therapy

Endoscopic surgery

Citation analysis

Bibliometric analysis

© 2025 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier España, S.L.U.

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