Epidermal radionuclide therapy with rhenium—the new treatment for skin squamous cell carcinoma

Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol. 2012;166(5):1069–80.

Article  CAS  PubMed  Google Scholar 

Nehal KS, Bichakjian CK. Update on keratinocyte carcinomas. N Engl J Med. 2018;379(4):363–74.

Article  CAS  PubMed  Google Scholar 

Bander TS, Nehal KS, Lee EH. Cutaneous squamous cell carcinoma: updates in staging and management. Dermatol Clin. 2019;37(3):241–51.

Article  CAS  PubMed  Google Scholar 

Schmults CD, Karia PS, Carter JB, Han J, Qureshi AA. Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study. JAMA Dermatol. 2013;149(5):541–7.

Article  PubMed  Google Scholar 

Brougham ND, Tan ST. The incidence and risk factors of metastasis for cutaneous squamous cell carcinoma—implications on the T‑classification system. J Surg Oncol. 2014;110(7):876–82.

Article  PubMed  Google Scholar 

Corchado-Cobos R, Garcia-Sancha N, Gonzalez-Sarmiento R, Perez-Losada J, Canueto J. Cutaneous squamous cell carcinoma: from biology to therapy. Int J Mol Sci. 2020;21(8).

Leiter U, Keim U, Eigentler T, Katalinic A, Holleczek B, Martus P, Garbe C. Incidence, mortality, and trends of nonmelanoma skin cancer in Germany. J Invest Dermatol. 2017;137(9):1860–7.

Article  CAS  PubMed  Google Scholar 

Brown VL, Harwood CA, Crook T, Cronin JG, Kelsell DP, Proby CM. p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma. J Invest Dermatol. 2004;122(5):1284–92.

Article  CAS  PubMed  Google Scholar 

Murao K, Kubo Y, Ohtani N, Hara E, Arase S. Epigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways. Br J Dermatol. 2006;155(5):999–1005.

Article  CAS  PubMed  Google Scholar 

Bernat-Peguera A, Simon-Extremera P, da Silva-Diz V, Lopez de Munain M, Diaz-Gil L, Penin RM, Gonzalez-Suarez E, Sidelnikova PD, Bermejo O, Vinals JM, et al. PDGFR-induced autocrine SDF‑1 signaling in cancer cells promotes metastasis in advanced skin carcinoma. Oncogene. 2019;38(25):5021–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zalaudek I, Argenziano G, Leinweber B, Citarella L, Hofmann-Wellenhof R, Malvehy J, Puig S, Pizzichetta MA, Thomas L, Soyer HP, et al. Dermoscopy of bowen’s disease. Br J Dermatol. 2004;150(6):1112–6.

Article  CAS  PubMed  Google Scholar 

Zalaudek I, Giacomel J, Schmid K, Bondino S, Rosendahl C, Cavicchini S, Tourlaki A, Gasparini S, Bourne P, Keir J, et al. Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: a progression model. J Am Acad Dermatol. 2012;66(4):589–97.

Article  PubMed  Google Scholar 

Wheeler DL, Dunn EF, Harari PM. Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nat Rev Clin Oncol. 2010;7(9):493–507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fahradyan A, Howell AC, Wolfswinkel EM, Tsuha M, Sheth P, Wong AK. Updates on the management of non-melanoma skin cancer (NMSC). Healthcare. 2017;5(4):82–81.

Article  PubMed  PubMed Central  Google Scholar 

Lansbury L, Bath-Hextall F, Perkins W, Stanton W, Leonardi-Bee J. Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies. BMJ. 2013;4:347–f6153.

Google Scholar 

Veness MJ. Hypofractionated radiotherapy in patients with non-melanoma skin cancer in the post COVID-19 era: time to reconsider its role for most patients. J Med Imaging Radiat Oncol. 2020;64(4):591–4.

Article  PubMed  PubMed Central  Google Scholar 

Boisbouvier S, Boucaud A, Tanguy R, Grégoire V. Upright patient positioning for pelvic radiotherapy treatments. Tech Innov Patient Support Radiat Oncol. 2022;28(24):124–30.

Article  Google Scholar 

Yang J, Nie J, Ma X, Wei Y, Peng Y, Wei X. Targeting PI3K in cancer: mechanisms and advances in clinical trials. Mol Cancer. 2019;18(1):26.

Article  PubMed  PubMed Central  Google Scholar 

Flies DB, Sandler BJ, Sznol M, Chen L. Blockade of the B7-H1/PD‑1 pathway for cancer immunotherapy. Yale J Biol Med. 2011;84(4):409–21.

CAS  PubMed  PubMed Central  Google Scholar 

Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, et al. PD‑1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma. N Engl J Med. 2018;379(4):341–51.

Article  CAS  PubMed  Google Scholar 

Sedda AF, Rossi G, Cipriani C, Carrozzo AM, Donati P. Dermatological high-dose-rate brachytherapy for the treatment of basal and squamous cell carcinoma. Clin Exp Dermatol. 2008;33(6):745–9.

Article  CAS  PubMed  Google Scholar 

Mirzaei S, Gabriel M, Wolf P, Posch C, Kunstfeld R, Laimer M, Bauer JW, Holler C. Rhenium-188 therapy of white skin cancer: position paper of the austrian societies for nuclear medicine and theranostics and dermatology and venereology.

Castellucci P, Savoia F, Farina A, Lima GM, Patrizi A, Baraldi C, Zagni F, Vichi S, Pettinato C, Morganti AG, et al. High dose brachytherapy with non sealed (188)re (rhenium) resin in patients with non-melanoma skin cancers (NMScs): single center preliminary results. Eur J Nucl Med Mol Imaging. 2021;48(5):1511–21.

Article  CAS  PubMed  Google Scholar 

Cipriani C, Desantis M, Dahlhoff G, Brown SD 3rd, Wendler T, Olmeda M, Pietsch G, Eberlein B. Personalized irradiation therapy for NMSC by rhenium-188 skin cancer therapy: a long-term retrospective study. J Dermatolog Treat. 2022;33(2):969–75.

Article  CAS  PubMed  Google Scholar 

Baxi S, Vohra S, Hong A, Mulholland N, Heuschkel M, Dahlhoff G, Cardaci G, Mirzaei S, Sathekge M. Effectiveness and patient experiences of rhenium skin cancer therapy for nonmelanoma skin cancer: interim results from the EPIC-skin study. J Nucl Med. 2024;65(9):1450–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ouhib Z, Kasper M, Calatayud PJ, Rodriguez S, Bhatnagar A, Pai S, Strasswimmer J. Aspects of dosimetry and clinical practice of skin brachytherapy: the American Brachytherapy society working group report. Brachytherapy. 2015;14(6):840–58.

Article  PubMed  Google Scholar 

Mirzaei S, Kunstfeld R. High-dose epidermal Radionuclide therapy with (188) re (rhenium) resin in a patient with multiple actinic keratoses. World J Nucl Med. 2024;23(4):285–7.

Article  PubMed  PubMed Central  Google Scholar 

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