Targeting the Hippo pathway in cancer

Tapon, N. et al. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110, 467–478 (2002).

Article  CAS  PubMed  Google Scholar 

Pantalacci, S., Tapon, N. & Leopold, P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat. Cell Biol. 5, 921–927 (2003).

Article  CAS  PubMed  Google Scholar 

Justice, R. W., Zilian, O., Woods, D. F., Noll, M. & Bryant, P. J. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 9, 534–546 (1995).

Article  CAS  PubMed  Google Scholar 

Xu, T., Wang, W., Zhang, S., Stewart, R. A. & Yu, W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121, 1053–1063 (1995).

Article  CAS  PubMed  Google Scholar 

Wu, S., Huang, J., Dong, J. & Pan, D. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with Salvador and Warts. Cell 114, 445–456 (2003).

Article  CAS  PubMed  Google Scholar 

Jia, J., Zhang, W., Wang, B., Trinko, R. & Jiang, J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 17, 2514–2519 (2003).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kango-Singh, M. et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129, 5719–5730 (2002).

Article  CAS  PubMed  Google Scholar 

Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C. & Halder, G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat. Cell Biol. 5, 914–920 (2003).

Article  CAS  PubMed  Google Scholar 

Harvey, K. F., Pfleger, C. M. & Hariharan, I. K. The Drosophila MST ortholog, Hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114, 457–467 (2003).

Article  CAS  PubMed  Google Scholar 

Gaspar, P. & Tapon, N. Sensing the local environment: actin architecture and Hippo signalling. Curr. Opin. Cell Biol. 31C, 74–83 (2014).

Article  Google Scholar 

Zheng, Y. & Pan, D. The Hippo signaling pathway in development and disease. Dev. Cell 50, 264–282 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng, Z., Moroishi, T. & Guan, K. L. Mechanisms of Hippo pathway regulation. Genes Dev. 30, 1–17 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moya, I. M. & Halder, G. Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine. Nat. Rev. Mol. Cell Biol. 20, 211–226 (2019).

Article  CAS  PubMed  Google Scholar 

Harvey, K. F., Zhang, X. & Thomas, D. M. The Hippo pathway and human cancer. Nat. Rev. Cancer 13, 246–257 (2013).

Article  CAS  PubMed  Google Scholar 

Staley, B. K. & Irvine, K. D. Hippo signaling in Drosophila: recent advances and insights. Dev. Dyn. 241, 3–15 (2012).

Article  CAS  PubMed  Google Scholar 

Enderle, L. & McNeill, H. Hippo gains weight: added insights and complexity to pathway control. Sci. Signal. 6, re7 (2013).

Article  PubMed  Google Scholar 

Huang, J., Wu, S., Barrera, J., Matthews, K. & Pan, D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 122, 421–434 (2005).

Article  CAS  PubMed  Google Scholar 

Dong, J. et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130, 1120–1133 (2007).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao, B. et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21, 2747–2761 (2007).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oka, T., Mazack, V. & Sudol, M. Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J. Biol. Chem. 283, 27534–27546 (2008).

Article  CAS  PubMed  Google Scholar 

Sebé-Pedrós, A., Zheng, Y., Ruiz-Trillo, I. & Pan, D. Premetazoan origin of the Hippo signaling pathway. Cell Rep. 1, 13–20 (2012).

Article  PubMed  Google Scholar 

Ikmi, A. et al. Molecular evolution of the Yap/Yorkie proto-oncogene and elucidation of its core transcriptional program. Mol. Biol. Evol. 31, 1375–1390 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mikeladze-Dvali, T. et al. The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell 122, 775–787 (2005).

Article  CAS  PubMed  Google Scholar 

Nishioka, N. et al. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev. Cell 16, 398–410 (2009).

Article  CAS  PubMed  Google Scholar 

Wang, Y. et al. Comprehensive molecular characterization of the Hippo signaling pathway in cancer. Cell Rep. 25, 1304–1317.e1305 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kulkarni, A., Chang, M. T., Vissers, J. H. A., Dey, A. & Harvey, K. F. The Hippo pathway as a driver of select human cancers. Trends Cancer 6, 781–796 (2020).

Article  CAS  PubMed  Google Scholar 

Zhou, D. et al. MST1 and MST2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the YAP1 oncogene. Cancer Cell 16, 425–438 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Camargo, F. D. et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr. Biol. 17, 2054–2060 (2007).

Article  CAS  PubMed  Google Scholar 

Lee, J. H. et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 27, 1231–1242 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kobayashi, S., Cox, A. G., Harvey, K. F. & Hogan, B. M. Vasculature is getting Hip(po): Hippo signaling in vascular development and disease. Dev. Cell 58, 2627–2640 (2023).

Article  CAS  PubMed  Google Scholar 

Heallen, T. et al. Hippo pathway inhibits WNT signaling to restrain cardiomyocyte proliferation and heart size. Science 332, 458–461 (2011).

Article  CAS  PubMed 

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