Impact of Medical Comorbidities on Ketamine and Esketamine Treatment Effectiveness for Posttraumatic Stress Disorder and Depression: A Clinical Outcomes Analysis from the VA San Diego Healthcare System

Agimi Y, Marion D, Schwab K, Stout K. Estimates of long-term disability among US service members with traumatic brain injuries. J Head Trauma Rehabil. 2021;36:1.

PubMed  Google Scholar 

McAllister T. Neurobehavioral sequelae of traumatic brain injury: evaluation and management. World Psychiatry. 2008;7:3–10.

PubMed  PubMed Central  Google Scholar 

Perry DC, Sturm VE, Peterson MJ, Pieper CF, Bullock T, Boeve BF, et al. Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis. J Neurosurg. 2016;124:511–26.

PubMed  Google Scholar 

Stein MB, Jain S, Giacino JT, Levin H, Dikmen S, Nelson LD, et al. Risk of posttraumatic stress disorder and major depression in civilian patients after mild traumatic brain injury: a TRACK-TBI study. JAMA Psychiat. 2019;76:249–58.

Google Scholar 

Choi Y, Kim EY, Sun J, Kim H-K, Lee YS, Oh B-M, et al. Incidence of depression after traumatic brain injury: a nationwide longitudinal study of 2.2 million adults. J Neurotrauma. 2022;39:390–7.

PubMed  PubMed Central  Google Scholar 

Bodnar CN, Morganti JM, Bachstetter AD. Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism. Neural Regen Res. 2018;13:1693–704.

CAS  PubMed  PubMed Central  Google Scholar 

Juengst SB, Kumar RG, Failla MD, Goyal A, Wagner AK. Acute inflammatory biomarker profiles predict depression risk following moderate to severe traumatic brain injury. J Head Trauma Rehabil. 2015;30:207–18.

PubMed  Google Scholar 

Frieden T, Houry D, Baldwin G. Report to congress on traumatic brain injury in the United States: epidemiology and rehabilitation. Atlanta, GA: Centers for Disease Control and Prevention National Center for Injury Prevention and Control; Division of Unintentional Injury Prevention; 2015.

Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in U.S. soldiers returning from Iraq. N Engl J Med. 2008;358:453–63.

CAS  PubMed  Google Scholar 

Fann JR, Bombardier CH, Temkin N, Esselman P, Warms C, Barber J, et al. Sertraline for major depression during the year following traumatic brain injury: a randomized controlled trial. J Head Trauma Rehabil. 2017;32:332–42.

PubMed  PubMed Central  Google Scholar 

Kreitzer N, Ancona R, McCullumsmith C, Kurowski BG, Foreman B, Ngwenya LB, et al. The effect of antidepressants on depression after traumatic brain injury: a meta-analysis. J Head Trauma Rehabil. 2019;34:E47-54.

PubMed  PubMed Central  Google Scholar 

Tsai PY, Chen YC, Wang JY, Chung KH, Lai CH. Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis. Sci Rep. 2021;11:1–16940.

Google Scholar 

Hoy KE, McQueen S, Elliot D, Herring SE, Maller JJ, Fitzgerald PB. A pilot investigation of repetitive transcranial magnetic stimulation for post-traumatic brain injury depression: safety, tolerability, and efficacy. J Neurotrauma. 2019;36:2092–8.

PubMed  Google Scholar 

Philip NS, Ramanathan D, Gamboa B, Brennan MC, Kozel FA, Lazzeroni L, et al. Repetitive transcranial magnetic stimulation for depression and posttraumatic stress disorder in veterans with mild traumatic brain injury. Neuromodulation. 2023;26:878–84.

PubMed  PubMed Central  Google Scholar 

Castriotta RJ, Murthy JN. Sleep disorders in patients with traumatic brain injury: a review. CNS Drugs. 2011;25:175–85.

CAS  PubMed  Google Scholar 

Aoun R, Rawal H, Attarian H, Sahni A. Impact of traumatic brain injury on sleep: an overview. Nat Sci Sleep. 2019;11:131–40.

PubMed  PubMed Central  Google Scholar 

Hobzova M, Prasko J, Vanek J, Ociskova M, Genzor S, Holubova M, et al. Depression and obstructive sleep apnea. Neuro Endocrinol Lett. 2017;38:343–52.

CAS  PubMed  Google Scholar 

Swanson TM, Isaacson BM, Cyborski CM, French LM, Tsao JW, Pasquina PF. Traumatic brain injury incidence, clinical overview, and policies in the US military health system since 2000. Public Health Rep. 2017;132:251–9.

PubMed  PubMed Central  Google Scholar 

Folmer RL, Smith CJ, Boudreau EA, Hickok AW, Totten AM, Kaul B, et al. Prevalence and management of sleep disorders in the Veterans Health Administration. Sleep Med Rev. 2020;54: 101358.

PubMed  Google Scholar 

Gupta MA, Simpson FC. Obstructive sleep apnea and psychiatric disorders: a systematic review. J Clin Sleep Med. 2015;11:165–75.

PubMed  PubMed Central  Google Scholar 

Haagsma JA, Scholten AC, Andriessen TMJC, Vos PE, Van Beeck EF, Polinder S. Impact of depression and post-traumatic stress disorder on functional outcome and health-related quality of life of patients with mild traumatic brain injury. J Neurotrauma. 2015;32:853–62.

PubMed  Google Scholar 

Mesa F, Dickstein BD, Wooten VD, Chard KM. Response to cognitive processing therapy in veterans with and without obstructive sleep apnea. J Trauma Stress. 2017;30:646–55.

PubMed  Google Scholar 

Grunebaum MF, Galfalvy HC, Choo T-H, Keilp JG, Moitra VK, Parris MS, et al. Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial. Am J Psychiatry. 2018;175:327–35.

PubMed  Google Scholar 

McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, et al. Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: an international expert opinion on the available evidence and implementation. Am J Psychiatry. 2021;178:383–99.

PubMed  PubMed Central  Google Scholar 

Daly EJ, Singh JB, Fedgchin M, Cooper K, Lim P, Shelton RC, Thase ME, Winokur A, Van Nueten L, Manji H, Drevets WC. Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: a randomized clinical trial. JAMA Psychiat. 2018;75(2):139–48.

Google Scholar 

Yamakura T, Sakimura K, Shimoji K. The stereoselective effects of ketamine isomers on heteromeric N-methyl-d-aspartate receptor channels. Anesth Analg. 2000;91(1):225–9.

CAS  PubMed  Google Scholar 

Zeilhofer HU, Swandulla D, Geisslinger G, Brune K. Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons. Eur J Pharmacol. 1992;213(1):155–8.

CAS  PubMed  Google Scholar 

Bahji A, Vazquez GH, Zarate CA Jr. Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis. J Affect Disord. 2021;278:542–55.

CAS  PubMed  Google Scholar 

Abdallah CG, Roache JD, Gueorguieva R, Averill LA, Young-McCaughan S, Shiroma PR, et al. Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology. 2022;47:1574–81.

CAS  PubMed  PubMed Central  Google Scholar 

Artin H, Bentley S, Mehaffey E, Liu FX, Sojourner K, Bismark AW, Printz D, Lee EE, Martis B, De Peralta S, Baker DG. Effects of intranasal (S)-ketamine on veterans with co-morbid treatment-resistant depression and PTSD: a retrospective case series. EClinicalMedicine. 2022;48:101439.

PubMed  PubMed Central  Google Scholar 

Shenasa MA, Afshar HT, Miller EA, Ellerman-Tayag E, Mishra J, Ramanathan D. Effects of cannabis use on antidepressant treatment response to repetitive transcranial magnetic stimulation and ketamine. Eur Neuropsychopharmacol. 2023;76:87–8.

CAS  PubMed  Google Scholar 

Titone MK, Hunt C, Bismark A, Nokes B, Lee E, Ramanathan D, et al. The effect of obstructive sleep apnea severity on PTSD symptoms during the course of esketamine treatment: a retrospective clinical study. J Clin Sleep Med. 2023;19:2043–51.

PubMed  PubMed Central  Google Scholar 

Miller EA, Afshar HT, Mishra J, McIntyre RS, Ramanathan D. Predicting non-response to ketamine for depression: an exploratory symptom-level analysis of real-world data among military veterans. Psychiatry Res. 2024;335: 115858.

CAS  PubMed  Google Scholar 

Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.

CAS  PubMed  PubMed Central  Google Scholar 

Beard C, Hsu KJ, Rifkin LS, Busch AB, Björgvinsson T. Validation of the PHQ-9 in a psychiatric sample. J Affect Disord. 2016;193:267–73.

CAS  PubMed  Google Scholar 

Blevins CA, Weathers FW, Davis MT, Witte TK, Domino JL. The posttraumatic stress disorder checklist for DSM-5 (PCL-5): development and initial psychometric evaluation. J Trauma Stress. 2015;28:489–98.

PubMed  Google Scholar 

Wortmann JH, Jordan AH, Weathers FW, Resick PA, Dondanville KA, Hall-Clark B, et al. Psychometric analysis of the PTSD Checklist-5 (PCL-5) among treatment-seeking military service members. Psychol Assess. 2016;28:1392–403.

PubMed  Google Scholar 

Morrison K, Su S, Keck M, Beidel DC. Psychometric properties of the PCL-5 in a sample of first responders. J Anxiety Disord. 2021;77: 102339.

PubMed  Google Scholar 

Yavi M, Lee H, Henter ID, Park LT, Zarate CA. Ketamine treatment for depression: a review. Discov Ment Health. 2022;2:9.

PubMed  PubMed Central  Google Scholar 

de Albuquerque TR, Macedo LFR, Delmondes GA, Rolim Neto ML, Almeida TM, Uchida RR, et al. Evidence for the beneficial effect of ketamine in the treatment of patients with post-traumatic stress disorder: a systematic review and meta-analysis. J Cereb Blood Flow Metab. 2022;42:2175–87.

CAS 

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