Georgakopoulos I, Kouloulias V, Ntoumas GN, Desse D, Koukourakis I, Kougioumtzopoulou A, Kanakis G, Zygogianni A. Radiotherapy and testicular function: a comprehensive review of the radiation-induced effects with an smphasis on spermatogenesis. Biomedicines. 2024;12:1492. https://doi.org/10.3390/biomedicines12071492.
Article CAS PubMed PubMed Central Google Scholar
Gawish RA, Fahmy HA, Abd El Fattah AI, Nada AS. Sodium selenite through targeting NRF2/STAT3 pathway attenuates testicular damage in irradiated rats. Pharm Chem J. 2024;58:18–26. https://doi.org/10.1007/s11094-024-03114-0.
Hu C, Wu Z, Zhang L, Ma Z, Liao Z, Gao Y. Isofraxidin alleviated radiation-induced testicular damage via the Nrf2/HO-1-NLRP3/ASC axis. Acupunct Herb Med. 2024;4:475–86. https://doi.org/10.1097/HM9.0000000000000137.
Yin J, Ye Y, Gao Y, Xu Q, Su M, Sun S, Xu W, Fu Q, Wang A, Hu S. Low-dose ionizing radiation and male reproductive immunity: elucidating subtle modulations and long-term health implications. Int J Mol Sci. 2025;26:2269. https://doi.org/10.3390/ijms26052269.
Article CAS PubMed PubMed Central Google Scholar
Kim JS, Heo K, Yi JM, Gong EJ, Yang K, Moon C, Kim SH. Genistein mitigates radiation-induced testicular injury. Phytother Res. 2012;26:1119–25. https://doi.org/10.1002/ptr.3689.
Article CAS PubMed Google Scholar
Silva AM, Correia S, Casalta-Lopes JE, Mamede AC, Cavaco JE, Botelho MF, Socorro S, Maia CJ. The protective effect of regucalcin against radiation-induced damage in testicular cells. Life Sci. 2016;164:31–41. https://doi.org/10.1016/j.lfs.2016.09.003.
Article CAS PubMed Google Scholar
Said RS, Mohamed HA, Kassem DH. Alpha-lipoic acid effectively attenuates ionizing radiation-mediated testicular dysfunction in rats: Crosstalk of NF-ĸB, TGF-β, and PPAR-ϒ pathways. Toxicology. 2020;442: 152536. https://doi.org/10.1016/j.tox.2020.152536.
Article CAS PubMed Google Scholar
Holley AK, Miao L, St Clair DK, St Clair WH. Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases. Antioxid Redox Signal. 2014;20:1567–89. https://doi.org/10.1089/ars.2012.5000.
Article CAS PubMed PubMed Central Google Scholar
Gawish RA, Fahmy HA, Abd El Fattah AI, Nada AS. The potential effect of methylseleninic acid (MSA) against γ-irradiation induced testicular damage in rats: Impact on JAK/STAT pathway. Arch Biochem Biophys. 2020;679. https://doi.org/10.1016/j.abb.2019.108205.
Kaur S, Nag A, Singh AK, Sharma K. PPARγ-targeting potential for radioprotection. Curr Drug Targets. 2018;19:1818–30. https://doi.org/10.2174/1389450119666180131105158.
Article CAS PubMed Google Scholar
Linard C, Souidi M. PPARs in irradiation-induced gastrointestinal toxicity. PPAR Res. 2010;2010: 528327. https://doi.org/10.1155/2010/528327.
Article CAS PubMed Google Scholar
Korbecki J, Bobiński R, Dutka M. Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors. Inflamm Res. 2019;68:443–58. https://doi.org/10.1007/s00011-019-01231-1.
Article CAS PubMed PubMed Central Google Scholar
Zhao W, Iskandar S, Kooshki M, Sharpe JG, Payne V, Robbins ME. Knocking out peroxisome proliferator-activated receptor (PPAR) alpha inhibits radiation-induced apoptosis in the mouse kidney through activation of NF-kappaB and increased expression of IAPs. Radiat Res. 2007;167:581–91. https://doi.org/10.1667/rr0814.1.
Article CAS PubMed Google Scholar
Packer L. Protective role of vitamin E in biological systems. Am J Clin Nutr. 1991;53:1050s–5s. https://doi.org/10.1093/ajcn/53.4.1050S.
Article CAS PubMed Google Scholar
Bisong SA, Ukoh IE, Nna VU, Ebong PE. Vitamin E attenuates nicotine- and noise-induced reproductive impairment in male albino Wistar rats. Andrologia. 2018;50: e13050. https://doi.org/10.1111/and.13050.
Article CAS PubMed Google Scholar
NadyOuais G, Kamar SA, Mousa AA, Sonbol MM. The protective effects of Vitamin E against alterations of rat testis structure induced by deltamethrin; histological, ultrastructure, and biochemical study. Ultrastruct Pathol. 2024;48:108–20. https://doi.org/10.1080/01913123.2023.2292563.
Gao Y, Jian L, Lu W, Xue Y, Machaty Z, Luo H. Vitamin E can promote spermatogenesis by regulating the expression of proteins associated with the plasma membranes and protamine biosynthesis. Gene. 2021;773:145364. https://doi.org/10.1016/j.gene.2020.145364.
Article CAS PubMed Google Scholar
Amanpour P, Khodarahmi P, Salehipour M. Protective effects of vitamin E on cadmium-induced apoptosis in rat testes. Naunyn Schmiedebergs Arch Pharmacol. 2020;393:349–58. https://doi.org/10.1007/s00210-019-01736-w.
Article CAS PubMed Google Scholar
Momeni HR, Oryan S, Eskandari N. Effect of vitamin E on sperm number and testis histopathology of sodium arsenite-treated rats. Reprod Biol. 2012;12:171–81. https://doi.org/10.1016/s1642-431x(12)60084-9.
Yin HP, Xu JP, Zhou XQ, Wang Y. Effects of vitamin E on reproductive hormones and testis structure in chronic dioxin-treated mice. Toxicol Ind Health. 2012;28:152–61. https://doi.org/10.1177/0748233711408381.
Article CAS PubMed Google Scholar
Ghosh D, Das UB, Misro M. Protective role of alpha-tocopherol-succinate (provitamin-E) in cyclophosphamide induced testicular gametogenic and steroidogenic disorders: a correlative approach to oxidative stress. Free Radic Res. 2002;36:1209–18. https://doi.org/10.1080/1071576021000016472.
Manna I, Jana K, Samanta PK. Intensive swimming exercise-induced oxidative stress and reproductive dysfunction in male wistar rats: protective role of alpha-tocopherol succinate. Can J Appl Physiol. 2004;29:172–85. https://doi.org/10.1139/h04-013.
Article CAS PubMed Google Scholar
TaheriChadorneshin H, Abtahi-Eivary S-H, Alipour-Raz M, Nezamdoost Z. The beneficial effect of α-tocopherol succinate supplementation on DNA oxidation induced by intensive exercise training. Sport Sci Health. 2019;15:183–90. https://doi.org/10.1007/s11332-018-0508-4.
Lee E, Choi MK, Lee YJ, Ku JL, Kim KH, Choi JS, Lim SJ. Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells. Carcinogenesis. 2006;27:2308–15. https://doi.org/10.1093/carcin/bgl073.
Article CAS PubMed Google Scholar
Topcu A, Mercantepe F, Rakici S, Tumkaya L, Uydu HA, Mercantepe T. An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats. Naunyn Schmiedebergs Arch Pharmacol. 2019;392:147–57. https://doi.org/10.1007/s00210-018-1581-6.
Article CAS PubMed Google Scholar
Mohamad S, Shuid AN, Mohamed N, Fadzilah FM, Mokhtar SA, Abdullah S, Othman F, Suhaimi F, Muhammad N, Soelaiman IN. The effects of alpha-tocopherol supplementation on fracture healing in a postmenopausal osteoporotic rat model. Clinics (Sao Paulo). 2012;67:1077–85. https://doi.org/10.6061/clinics/2012(09)16.
Takhshid MA, Tavasuli AR, Heidary Y, Keshavarz M, Kargar H. Protective effect of vitamins e and C on endosulfan-induced reproductive toxicity in male rats. Iran J Med Sci. 2012;37:173–80.
PubMed PubMed Central Google Scholar
Kara Y, Akyuz F. Effects of N-nitro L-arginine methyl ester and α-tocopherol on testicular oxidative stress caused by exposure to cigarette smoke. Andrologia. 2019;51: e13355. https://doi.org/10.1111/and.13355.
Article CAS PubMed Google Scholar
Field KJ, White WJ, Lang CM. Anaesthetic effects of chloral hydrate, pentobarbitone and urethane in adult male rats. Lab Anim. 1993;27:258–69. https://doi.org/10.1258/002367793780745471.
Comments (0)