Primary subclavian venous thrombosis (PSVT) is a rare but potentially disabling condition caused by chronic compression of the subclavian vein at the thoracic outlet, typically affecting young individuals. Delayed diagnosis often leads to post-thrombotic syndrome (PTS) due to missed opportunities for early surgical intervention. In Stockholm, Sweden, a regional awareness and referral program initiated in 2013 significantly increased early detection and intervention rates. Between 2013 and 2024, 283 PSVT cases were identified, with incidence rising from 0.6 to 1.5 per 100,000/year, attributed to improved detection. Early surgical intervention rose from 66% to 83%, while PTS cases requiring delayed surgery dropped by 50%. These results underscore the benefit of structured regional programs.

The authors have declared no competing interest.

This work was supported by local grants from the Department of Surgery at Södersjukhuset and private donations from Kjell Sten and Anne-Lie Rydé. All authors confirm independence from funders.

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Ethical permit was approved by the Regional Ethical Review Board in Stockholm 2017-01-18 (DNR 2016/2484-31/2).

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