A continuous energy supply is essential for metabolism, homeostasis, cell growth, and development (Das et al., 2022; Das, Afzal, Wann, Kalita, & Manna, 2023). Heterotrophic organisms produce energy at the expense of nutrients, resulting in the creation of high-energy molecules like ATP (Lizák et al., 2019). The transportation of glucose is essential for the metabolism of energy. Key metabolic processes involve transporting glucose to peripheral tissues for storage and utilization as well as maintaining a relatively constant blood glucose concentration to support cerebral metabolism (Brown, 2000). In many cases, glucose transport across cell membranes is a critical component in the regulation and control of these processes. Protein transporters are required to facilitate the transfer of glucose into and out of cells because cell membranes are practically impermeable to glucose. Altered expression of glucose transporters is a major characteristic of diabetes. Due to the reduced activity of the transporters, the utilization of glucose by the cells is diminished, causing hyperglycemia (Sonia et al., 2024; Tamilselvan, Seshadri, & Venkatraman, 2013). Glucose transporters play a critical role in the regulation of glucose metabolism and maintenance of body glucose homeostasis (Dihingia, Ozah, Borah, Kalita, & Manna, 2020). The absorption of glucose into the intestinal mucosa and the kidney’s storage of glucose is brought about by the secondary active transport system. There is a family of glucose transporters that distribute glucose to the various tissues of our body, and they all have unique kinetic characteristics (Navale & Paranjape, 2016). Numerous distinct glucose transporters are expressed by most cells, and the pattern of expression in various organs is associated with particular metabolic needs (Brown, 2000; Govers, 2014).

It is already known from several studies that vitamin supplementation can significantly reduce all-cause of mortality and cardiovascular disease (CVD) mortality (Nemeth, Patonai, Simon-Szabó, & Takács, 2023). Additionally, it is acknowledged that vitamin deficiency are associated with several diseases, e.g., obesity, metabolic syndrome, immune dysfunction, insulin resistance, etc (Barker, 2023). Recently, lipid soluble vitamins (A, D, E, and K) has gained scientific attention in regulating the expression of various glucose transporters (GLUT) in mitigating several non-communicable diseases, like CVS, type 2 diabetes (T2D), obesity, and cancer. The present article primarily discusses the essential role of lipid soluble vitamins on the regulation of glucose transporters.