If humans are like rodents, as they so far appear to be regarding expression of prolactin receptors, almost all tissues express some form of the prolactin receptor, although not all cells within any given tissue are positive (Aoki et al., 2019, Ben-Jonathan et al., 2008, Ouhtit et al., 1993, Ouhtit et al., 1994, Tzeng and Linzer, 1997). Treatment with the LFPRLR SMO therefore has the potential to impact multiple tissues. Most affected, however, will be cells expressing high levels of LF