Silverberg DS, Wexler D, Blum M, Keren G, Sheps D, Leibovitch E, Brosh D, Laniado S, Schwartz D, Yachnin T, Shapira I, Gavish D, Baruch R, Koifman B, Kaplan C, Steinbruch S, Iaina A (2000) The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol 35:1737–1744

Article  PubMed  CAS  Google Scholar 

Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Borenstein J (2002) Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol 39:1780–1786

Article  PubMed  Google Scholar 

Felker GM, Gattis WA, Leimberger JD, Adams KF, Cuffe MS, Gheorghiade M, O’Connor CM (2003) Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. Am J Cardiol 92:625–628

Article  PubMed  Google Scholar 

Groenveld HF, Januzzi JL, Damman K, van Wijngaarden J, Hillege HL, van Veldhuisen DJ, van der Meer P (2008) Anemia and mortality in heart failure patients a systematic review and meta-analysis. J Am Coll Cardiol 52:818–827

Article  PubMed  Google Scholar 

Anand IS (2008) Anemia and chronic heart failure implications and treatment options. J Am Coll Cardiol 52:501–511

Article  PubMed  Google Scholar 

Go AS, Yang J, Ackerson LM, Lepper K, Robbins S, Massie BM, Shlipak MG (2006) Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the anemia in chronic heart failure: outcomes and resource utilization (ANCHOR) study. Circulation 113:2713–2723

Article  PubMed  CAS  Google Scholar 

Salisbury AC, Amin AP, Reid KJ, Wang TY, Masoudi FA, Chan PS, Alexander KP, Bach RG, Spertus JA, Kosiborod M (2011) Hospital-acquired anemia and in-hospital mortality in patients with acute myocardial infarction. Am Heart J 162:300-309.e3

Article  PubMed  Google Scholar 

Eikelboom JW, Mehta SR, Anand SS, Xie C, Fox KA, Yusuf S (2006) Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 114:774–782

Article  PubMed  Google Scholar 

Rao SV, O’Grady K, Pieper KS, Granger CB, Newby LK, Van de Werf F, Mahaffey KW, Califf RM, Harrington RA (2005) Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. Am J Cardiol 96:1200–1206

Article  PubMed  Google Scholar 

Kwok CS, Tiong D, Pradhan A, Andreou AY, Nolan J, Bertrand OF, Curzen N, Urban P, Myint PK, Zaman AG, Loke YK, Mamas MA (2016) Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention. Am J Cardiol 118:610–620

Article  PubMed  Google Scholar 

Sakai S, Tara S, Yamamoto T, Asano K, Kimura T, Fujimoto Y, Shiomura R, Matsuda J, Kadooka K, Takahashi K, Ko T, Sangen H, Saiki Y, Nakata J, Hosokawa Y, Takano H, Shimizu W (2021) Gastrointestinal bleeding increases the risk of subsequent cardiovascular events in patients with acute cardiovascular diseases requiring intensive care. Heart Vessels 36:1327–1335

Article  PubMed  Google Scholar 

Nakamura M, Yamagishi M, Ueno T, Hara K, Ishiwata S, Itoh T, Hamanaka I, Wakatsuki T, Sugano T, Kawai K, Kimura T (2013) Current antiplatelet therapy for Japanese patients with ST elevation acute myocardial infarction: J-AMI registry. Cardiovasc Interv Ther 28:162–169

Article  PubMed  CAS  Google Scholar 

Ponikowski P, van Veldhuisen DJ, Comin-Colet J, Ertl G, Komajda M, Mareev V, McDonagh T, Parkhomenko A, Tavazzi L, Levesque V, Mori C, Roubert B, Filippatos G, RuschitzkaAnker FSD, CONFIRM-HF Investigators (2015) Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J 36:657–668

Article  PubMed  CAS  Google Scholar 

Swedberg K, Young JB, Anand IS, Cheng S, Desai AS, Diaz R, Maggioni AP, McMurray JJV, O’Connor C, Pfeffer MA, Solomon SD, Sun Y, Tendera M, van Veldhuisen DJ, Committees RED-HF, Investigators RED-HF (2013) Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 368:1210–1219

Article  PubMed  CAS  Google Scholar 

Carson JL, Brooks MM, Hébert PC, Goodman SG, Bertolet M, Glynn SA, Chaitman BR, Simon T, Lopes RD, Goldsweig AM, DeFilippis AP, Abbott JD, Potter BJ, Carrier FM, Rao SV, Cooper HA, Ghafghazi S, Fergusson DA, Kostis WJ, Noveck H, Kim S, Tessalee M, Ducrocq G, Silva PGME, Triulzi DJ, Alsweiler C, Menegus MA, Neary JD, Uhl L, Strom JB, Fordyce CB, Ferrari E, Silvain J, Wood FO, Daneault B, Polonsky TS, Senaratne M, Puymirat E, Bouleti C, Lattuca B, White HD, Kelsey SF, Steg PG, Alexander JH, MINT Investigators (2023) Restrictive or liberal transfusion strategy in myocardial infarction and anemia. N Engl J Med 389:2446–2456

Article  PubMed  PubMed Central  CAS  Google Scholar 

Docherty AB, O’Donnell R, Brunskill S, Trivella M, Doree C, Holst L, Parker M, Gregersen M, de Almeida JP, Walsh TS, Stanworth SJ (2016) Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. BMJ 352:i1351

Article  PubMed  PubMed Central  Google Scholar 

Ducrocq G, Gonzalez-Juanatey JR, Puymirat E, Lemesle G, Cachanado M, Durand-Zaleski I, Arnaiz JA, Martínez-Sellés M, Silvain J, Ariza-Solé A, Ferrari E, Calvo G, Danchin N, Avendaño-Solá C, Frenkiel J, Rousseau A, Vicaut E, Simon T, Steg PG, REALITY Investigators (2021) Effect of a restrictive vs liberal blood transfusion strategy on major cardiovascular events among patients with acute myocardial infarction and anemia: the REALITY randomized clinical trial. JAMA 325:552–560

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jentzer JC, van Diepen S, Barsness GW, Katz JN, Wiley BM, Bennett CE, Mankad SV, Sinak LJ, Best PJ, Herrmann J, Jaffe AS, Murphy JG, Morrow DA, Wright RS, Bell MR, Anavekar NS (2019) Changes in comorbidities, diagnoses, therapies and outcomes in a contemporary cardiac intensive care unit population. Am Heart J 215:12–19

Article  PubMed  Google Scholar 

Yonemura Y, Matsumoto M, Inada E, Ueda Y, Ohishi K, Kubo T, Kumakawa M, Sueoka E, Sonoki T, Nagai K, Fujishima N, Matsushita T (2018) Guideline for the use of red blood cell products based on scientific evidence (revision 2nd edition). Jpn J Trans Cell Ther 64:688–699

Google Scholar 

Suh JW, Mehran R, Claessen BE, Xu K, Baber U, Dangas G, Parise H, Lansky AJ, Witzenbichler B, Grines CL, Guagliumi G, Kornowski R, Wöhrle J, Dudek D, Weisz G, Stone GW (2011) Impact of in-hospital major bleeding on late clinical outcomes after primary percutaneous coronary intervention in acute myocardial infarction the HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trial. J Am Coll Cardiol 58:1750–1756

Article  PubMed  Google Scholar 

Tian Y, Yao Y, Zhou J, Diao X, Chen H, Cai K, Ma X, Wang S (2022) Dynamic APACHE II score to predict the outcome of intensive care unit patients. Front Med (Lausanne) 8:744907

Article  PubMed  Google Scholar 

Cavalcante Dos Santos E, Orbegozo D, Mongkolpun W, Galfo V, Nan W, Gouvêa Bogossian E, Taccone FS, Vallet B, Creteur J, Vincent J (2020) Systematic review and meta-analysis of effects of transfusion on hemodynamic and oxygenation variables. Crit Care Med 48:241–248

Article  PubMed  Google Scholar 

Raghavan M, Marik PE (2005) Anemia, allogenic blood transfusion, and immunomodulation in the critically ill. Chest 127:295–307

Article  PubMed  Google Scholar 

Baker CH, Wilmoth FR, Sutton ET (1986) Reduced RBC versus plasma microvascular flow due to endotoxin. Circ Shock 20:127–139

PubMed  CAS  Google Scholar 

Wu WC, Rathore SS, Wang Y, Radford MJ, Krumholz HM (2001) Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med 345:1230–1236

Article  PubMed  CAS  Google Scholar 

Aronson D, Dann EJ, Bonstein L, Blich M, Kapeliovich M, Beyar R, Markiewicz W, Hammerman H (2008) Impact of red blood cell transfusion on clinical outcomes in patients with acute myocardial infarction. Am J Cardiol 102:115–119

Article  PubMed  Google Scholar 

Nikolsky E, Mehran R, Sadeghi HM, Grines CL, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Fahy M, Lansky AJ, Stone GW (2009) Prognostic impact of blood transfusion after primary angioplasty for acute myocardial infarction: analysis from the CADILLAC (controlled abciximab and device investigation to lower late angioplasty complications) trial. JACC Cardiovasc Interv 2:624–632

Article  PubMed  Google Scholar 

Singla I, Zahid M, Good CB, Macioce A, Sonel AF (2007) Impact of blood transfusions in patients presenting with anemia and suspected acute coronary syndrome. Am J Cardiol 99:1119–1121

Article  PubMed  Google Scholar 

Shishehbor MH, Madhwal S, Rajagopal V, Hsu A, Kelly P, Gurm HS, Kapadia SR, Lauer MS, Topol EJ (2009) Impact of blood transfusion on short- and long-term mortality in patients with ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 2:46–53

Article  PubMed  Google Scholar 

Allonen J, Nieminen MS, Hiippala S, Sinisalo J (2018) Relation of use of red blood cell transfusion after acute coronary syndrome to long-term mortality. Am J Cardiol 121:1496–1504

Article