Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.
Yamamoto T, Takahashi A, Yoshizumi T, Ishihara S, Inomata M, Imoto S, et al. 2023 National clinical database annual report by the Japan surgical society. Surg Today. 2025;55:295–334.
Article PubMed PubMed Central Google Scholar
Okami J, Shintani Y, Okumura M, Ito H, Ohtsuka T, Toyooka S, et al. Demographics, safety and quality, and prognostic information in both the seventh and eighth editions of the TNM classification in 18,973 surgical cases of the japanese joint committee of lung cancer registry database in 2010. J Thorac Oncol. 2019;14:212–22.
Aro R, Makarainen-Uhlback E, Ammala N, Rautio T, Ohtonen P, Saarnio J, et al. The impact of sarcopenia and myosteatosis on postoperative outcomes and 5-year survival in curatively operated colorectal cancer patients - A retrospective register study. Eur J Surg Oncol. 2020;46:1656–62.
Cinar HU, Celik B, Taskin G, Ince O. Impact of preoperative computed tomography-determined quantity and quality of skeletal muscle on survival after resected non-small cell lung carcinoma. Eur J Surg Oncol. 2022;48:1937–46.
Okumura S, Kaido T, Hamaguchi Y, Fujimoto Y, Masui T, Mizumoto M, et al. Impact of preoperative quality as well as quantity of skeletal muscle on survival after resection of pancreatic cancer. Surgery. 2015;157:1088–98.
Sato R, Oikawa M, Kakita T, Okada T, Abe T, Akazawa N, et al. Prognostic significance of Ishii’s sarcopenia screening score for patients undergoing curative surgery for obstructive colorectal cancer after intraluminal decompression. Surg Today. 2024;54:683–91.
Nakamura R, Inage Y, Tobita R, Yoneyama S, Numata T, Ota K, et al. Sarcopenia in resected NSCLC: effect on postoperative outcomes. J Thorac Oncol. 2018;13:895–903.
Sato S, Sato M, Shinohara H. Significance of preoperative evaluation of skeletal muscle index and immune-nutritional status for patients with early-stage non-small cell lung cancer. Gen Thorac Cardiovasc Surg. 2023;71:354–62.
Shinohara S, Otsuki R, Kobayashi K, Sugaya M, Matsuo M, Nakagawa M. Impact of sarcopenia on surgical outcomes in non-small cell lung cancer. Ann Surg Oncol. 2020;27:2427–35.
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39:412–23.
Article PubMed PubMed Central Google Scholar
Ahn H, Kim DW, Ko Y, Ha J, Shin YB, Lee J, et al. Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia. Ageing Res Rev. 2021;70:101398.
Jing X, Tan L, Fu H, Yang L, Yang M. Associations of ADL disability with trunk muscle mass and muscle quality indicators measured by opportunistic chest computed tomography imaging among older inpatients. Front Med (Lausanne). 2021;8:743698.
Stretch C, Aubin JM, Mickiewicz B, Leugner D, Al-Manasra T, Tobola E, et al. Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas. PLoS ONE. 2018;13: e0196235.
Article PubMed PubMed Central Google Scholar
Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr. 2009;90:1579–85.
Article CAS PubMed PubMed Central Google Scholar
Miljkovic I, Kuipers AL, Cvejkus R, Bunker CH, Patrick AL, Gordon CL, et al. Myosteatosis increases with aging and is associated with incident diabetes in African ancestry men. Obesity (Silver Spring). 2016;24:476–82.
Article CAS PubMed Google Scholar
Goodpaster BH, Theriault R, Watkins SC, Kelley DE. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism. 2000;49:467–72.
Article CAS PubMed Google Scholar
Goodpaster BH, Carlson CL, Visser M, Kelley DE, Scherzinger A, Harris TB, et al. Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. J Appl Physiol. 1985;2001(90):2157–65.
Murnane LC, Forsyth AK, Koukounaras J, Pilgrim CH, Shaw K, Brown WA, et al. Myosteatosis predicts higher complications and reduced overall survival following radical oesophageal and gastric cancer surgery. Eur J Surg Oncol. 2021;47:2295–303.
Aust S, Knogler T, Pils D, Obermayr E, Reinthaller A, Zahn L, et al. Skeletal muscle depletion and markers for cancer cachexia are strong prognostic factors in epithelial ovarian cancer. PLoS ONE. 2015;10: e0140403.
Article PubMed PubMed Central Google Scholar
Gronberg BH, Sjoblom B, Wentzel-Larsen T, Baracos VE, Hjermstad MJ, Aass N, et al. A comparison of CT based measures of skeletal muscle mass and density from the Th4 and L3 levels in patients with advanced non-small-cell lung cancer. Eur J Clin Nutr. 2019;73:1069–76.
Hamrick MW, McGee-Lawrence ME, Frechette DM. Fatty Infiltration of Skeletal Muscle: Mechanisms and Comparisons with Bone Marrow Adiposity. Front Endocrinol (Lausanne). 2016;7:69.
Aubrey J, Esfandiari N, Baracos VE, Buteau FA, Frenette J, Putman CT, et al. Measurement of skeletal muscle radiation attenuation and basis of its biological variation. Acta Physiol (Oxf). 2014;210:489–97.
Article CAS PubMed Google Scholar
Taaffe DR, Henwood TR, Nalls MA, Walker DG, Lang TF, Harris TB. Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults. Gerontology. 2009;55:217–23.
van Vugt JLA, Coebergh van den Braak RRJ, Schippers HJW, Veen KM, Levolger S, de Bruin RWF, et al. Contrast-enhancement influences skeletal muscle density, but not skeletal muscle mass, measurements on computed tomography. Clin Nutr. 2018;37:1707–14.
Chen WZ, Shen ZL, Zhang FM, Zhang XZ, Chen WH, Yan XL, et al. Prognostic value of myosteatosis and sarcopenia for elderly patients with colorectal cancer: A large-scale double-center study. Surgery. 2022;172:1185–93.
Yamashita S, Iwahashi Y, Miyai H, Iguchi T, Koike H, Nishizawa S, et al. Myosteatosis as a novel prognostic biomarker after radical cystectomy for bladder cancer. Sci Rep. 2020;10:22146.
Article CAS PubMed PubMed Central Google Scholar
Youn S, Eurich DT, McCall M, Walker J, Smylie M, Sawyer MB. Skeletal muscle is prognostic in resected stage III malignant melanoma. Clin Nutr. 2022;41:1066–72.
Article CAS PubMed Google Scholar
Roden M. Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetes. Int J Obes (Lond). 2005;29(Suppl 2):S111-5.
Article CAS PubMed Google Scholar
Kovalik JP, Slentz D, Stevens RD, Kraus WE, Houmard JA, Nicoll JB, et al. Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system. Diabetes. 2011;60:1882–93.
Article CAS PubMed PubMed Central Google Scholar
Miljkovic I, Cauley JA, Wang PY, Holton KF, Lee CG, Sheu Y, et al. Abdominal myosteatosis is independently associated with hyperinsulinemia and insulin resistance among older men without diabetes. Obesity (Silver Spring). 2013;21:2118–25.
Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4:579–91.
Article CAS PubMed Google Scholar
Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol. 2012;8:457–65.
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