Kwon JJ, Factora TD, Dey S, Kota J (2019) A systematic review of miR-29 in cancer. Mol Therapy-Oncolytics 12:173–194

Article  CAS  Google Scholar 

Zeng Y, Chen T (2019) DNA methylation reprogramming during mammalian development. Genes 10(4):257

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wojtas B, MJD (2019) Global DNA methylation patterns in human gliomas and their interplay with other epigenetic modifications. Int J Mol Sci 20(14)

Zhang X, Zhang Y, Wang C, Wang X (2023) TET (Ten-eleven translocation) family proteins: structure, biological functions and applications. Signal Transduct Target Therapy 8(1):297

Article  CAS  Google Scholar 

Yang L, Yu S-J, Hong Q, Yang Y, Shao Z-M (2015) Reduced expression of TET1, TET2, TET3 and TDG mRNAs are associated with poor prognosis of patients with early breast cancer. PLoS ONE 10(7):e0133896

Article  PubMed  PubMed Central  Google Scholar 

Wong KK (ed) (2021) Editor DNMT1: A key drug target in triple-negative breast cancer. Seminars in cancer biology. Elsevier

Wong KK (2020) DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications. Cell Oncol 43(5):779–792

Article  CAS  Google Scholar 

Zhang T-J, Zhang L-C, Xu Z-J, Zhou J-D (2020) Expression and prognosis analysis of DNMT family in acute myeloid leukemia. Aging 12(14):14677

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kataoka I, Funata S, Nagahama K, Isogaya K, Takeuchi H, Abe N et al (2020) DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma. Annals Diagn Pathol 44:151456

Article  Google Scholar 

Rasmussen KD, Helin K (2016) Role of TET enzymes in DNA methylation, development, and cancer. Genes Dev 30(7):733–750

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ke Q, Wang K, Fan M, Li M, Luo G, Wang D (2020) Prognostic role of high TET1 expression in patients with solid tumors: A meta-analysis. Med (Baltim) 99(44):e22863

Article  CAS  Google Scholar 

Hsu C-H, Peng K-L, Kang M-L, Chen Y-R, Yang Y-C, Tsai C-H et al (2012) TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell Rep 2(3):568–579

Article  PubMed  CAS  Google Scholar 

Good CR, Panjarian S, Kelly AD, Madzo J, Patel B, Jelinek J et al (2018) TET1-Mediated hypomethylation activates oncogenic signaling in Triple-Negative breast cancer. Cancer Res 78(15):4126–4137

Article  PubMed  PubMed Central  CAS  Google Scholar 

Goni R, García P, Foissac S (2009) The qPCR data statistical analysis. Integromics White Paper 1:1–9

Google Scholar 

Barthel FP, Johnson KC, Varn FS et al (2019) Longitudinal molecular trajectories of diffuse glioma in adults. Nature 576:112–120

Cerami E, Gao J, Dogrusoz U et al (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401–404

Gao J, Aksoy BA, Dogrusoz U et al (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6:pl1

de Bruijn I, Kundra R, Mastrogiacomo B et al (2023) Analysis and visualization of longitudinal genomic and clinical data from the AACR Project GENIE Biopharma Collaborative in cBioPortal. Cancer Res 83:3861–3867

Zhao Z, Zhang KN, Wang Q et al (2021) Chinese glioma genome atlas (CGGA): a comprehensive resource with functional genomic data from Chinese glioma patients. Genomics Proteomics Bioinformatics 19:1–12

Hanahan D (2022) Hallmarks of cancer: new dimensions. Cancer Discov 12(1):31–46

Article  PubMed  CAS  Google Scholar 

An J, Rao A, Ko M (2017) TET family dioxygenases and DNA demethylation in stem cells and cancers. Exp Mol Med 49(4):e323–e

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chao L, Yang S, Li H, Long C, Xi Q, Zuo Y (2022) Competitive binding of TET1 and DNMT3A/B cooperates the DNA methylation pattern in human embryonic stem cells. Biochim Et Biophys Acta (BBA)-Gene Regul Mech 1865(7):194861

Article  CAS  Google Scholar 

Wu Z, Huang K, Yu J, Le T, Namihira M, Liu Y et al (2012) Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. J Neurosci Res 90(10):1883–1891

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kreth S, Thon N, Eigenbrod S, Lutz J, Ledderose C, Egensperger R et al (2011) O6-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. PLoS ONE 6(2):e17156

Article  PubMed  PubMed Central  CAS  Google Scholar 

Babaeenezhad E, Moradi Sarabi M, Rajabibazl M, Oraee-Yazdani S, Karima S (2023) Global and regional DNA methylation Silencing of PPARγ associated with glioblastoma multiforme pathogenesis. Mol Biol Rep 50(1):589–597

Article  PubMed  CAS  Google Scholar 

Boot J, Rosser G, Kancheva D, Vinel C, Lim YM, Pomella N et al (2022) Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape. Elife 11:e77335

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dabrowski J, Wojtas M (2019) Global DNA methylation patterns in human gliomas and their interplay with other epigenetic modifications. Int J Mol Sci 20(14):3478

Article  CAS  Google Scholar 

Lopez-Bertoni H, Johnson A, Rui Y, Lal B, Sall S, Malloy M et al (2022) Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications. Signal Transduct Target Therapy 7(1):37

Article  CAS  Google Scholar 

Lu J, Zhen S, Tuo X, Chang S, Yang X, Zhou Y et al (2022) Downregulation of DNMT3A attenuates the Warburg effect, proliferation, and invasion via promoting the Inhibition of miR-603 on HK2 in ovarian cancer. Technol Cancer Res Treat 21:15330338221110668

Article  PubMed  PubMed Central  CAS  Google Scholar 

Su X, Liu J, Tu Z, Ji Q, Li J, Liu F (2024) DNMT3A promotes glioma growth and malignancy via TNF-α/NF-κB signaling pathway. Translational cancer Res 13(4):1786

Article  CAS  Google Scholar 

Li W, Liu S, Wang C, Cui L, Zhao X, Liu W et al (2023) DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to Daunorubicin on leukemic cells. BMC Cancer 23(1):255

Article  PubMed  PubMed Central  Google Scholar 

Zhao Y, Zheng Y, Fu J et al (2024) KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer. Br J Cancer 131:655–667

Solomou G, Finch A, Asghar A, Bardella C (2023) Mutant IDH in gliomas: role in cancer and treatment options. Cancers 15(11):2883

Article  PubMed  PubMed Central  CAS  Google Scholar 

Heiland D, Ferrarese R, Claus R, Dai F, Masilamani A, Kling E et al (2017) c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas. Oncotarget 8:6940–6954

Article  PubMed  Google Scholar 

Huang D-Y, Lu S-T, Chen Y-S, Cheng C-Y, Lin W-W (2023) Epigenetic upregulation of spleen tyrosine kinase in cancer cells through p53-dependent downregulation of DNA methyltransferase. Exp Cell Res 425(2):113540

Article  PubMed  CAS  Google Scholar 

Peterson EJ, Bögler O, Taylor SM (2003) p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. Cancer Res 63(20):6579–6582

PubMed  CAS  Google Scholar 

LeBlanc VG, Marra MA (2016) DNA methylation in adult diffuse gliomas. Brief Funct Genomics 15(6):491–500

PubMed  CAS  Google Scholar 

Li LT, Wang X, Zhu WT, Qian GW, Pei DS, Zheng JN (2019) Reciprocal role of DNA methylation and Sp1 binding in Ki-67 gene transcription. Cancer Manag Res 11:9749–9759

Brągiel-Pieczonka A, Lipka G, Stapińska-Syniec A, Czyżewski M, Żybura-Broda K, Sobstyl M et al (2022) The profiles of Tet-mediated DNA hydroxymethylation in human gliomas. Front Oncol 12:621460

Article  PubMed  PubMed Central  Google Scholar 

Orr BA, Haffner MC, Nelson WG, Yegnasubramanian S, Eberhart CG (2012) Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. PLoS ONE 7(7):e41036

Article  PubMed