Rhodes KA, Schweizer HP (2016) Antibiotic resistance in Burkholderia species. Drug Resist Updates 28:82–90. https://doi.org/10.1016/j.drup.2016.07.003

Article  Google Scholar 

Xu K-Z, You C, Wang Y-J, Dar OI, Yin L-J, Xiang S-L et al (2024) Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis. Med Microbiol Immunol 213(1). https://doi.org/10.1007/s00430-024-00799-8

Foweraker J (2008) Recent advances in the microbiology of respiratory tract infection in cystic fibrosis. Br Med Bull 89(1):93–110. https://doi.org/10.1093/bmb/ldn050

Article  Google Scholar 

Kunakom S, Eustáquio AS (2019) Burkholderia as a source of natural products. J Nat Prod 82(7):2018–2037. https://doi.org/10.1021/acs.jnatprod.8b01068

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drevinek P, Mahenthiralingam E (2010) Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence. Clin Microbiol Infect 16(7):821–830. https://doi.org/10.1111/j.1469-0691.2010.03237.x

Article  CAS  PubMed  Google Scholar 

Loutet SA, Valvano MA (2010) A decade of Burkholderia cenocepacia virulence determinant research. Infect Immun 78(10):4088–4100. https://doi.org/10.1128/iai.00212-10

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malott RJ, O’Grady EP, Toller J, Inhülsen S, Eberl L, Sokol PA (2009) A Burkholderia cenocepacia orphan LuxR homolog is involved in Quorum-Sensing regulation. J Bacteriol 191(8):2447–2460. https://doi.org/10.1128/Jb.01746-08

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Grady EP, Viteri DF, Malott RJ, Sokol PA (2009) Reciprocal regulation by the cepir and CciIR quorum sensing systems in Burkholderia cenocepacia. BMC Genomics 10(1). https://doi.org/10.1186/1471-2164-10-441

Yinyue Deng AL, Jing Wang T, Zhou S, Chen J, Lee, Yi-Hu D, Lian-Hui Zhang (2013) Cis-2-dodecenoic acid quorum sensing system modulates N-acyl Homoserine lactone production through RpfR and Cyclic di-GMP turnover in Burkholderia cenocepacia. BMC Microbiol 13:148. https://doi.org/10.1186/1471-2180-13-148

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui CS, Shihao, Yang C, Xiuyun S, Huang, Yutong, Li K, Zhao RE (2019) Disruption of Quorum Sensing and Virulence in Burkholderia cenocepacia by a Structural Analogue of the cis-2-Dodecenoic Acid Signal. Applied and Environmental Microbiology 85(8)https://doi.org/10.1128/aem.00105-19

Xiu-Qi Tian YW, Cai Z, Qian W (2022) BDSF is a degradation-prone quorum-sensing signal detected by the histidine kinase RpfC of Xanthomonas campestris Pv. campestris. Appl Environ Microbiol 26(888):e0003122. https://doi.org/10.1128/aem.00031-22

Article  CAS  Google Scholar 

Zhou L, Zhang LH, Cámara M, He YW (2017) The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover. Trends Microbiol 25(4):293–303. https://doi.org/10.1016/j.tim.2016.11.013

Article  CAS  PubMed  Google Scholar 

Kameswaran S, Gujjala S, Zhang S, Kondeti S, Mahalingam S, Bangeppagari M et al (2024) Quenching and quorum sensing in bacterial bio-films. Res Microbiol 175(3):104085. https://doi.org/10.1016/j.resmic.2023.104085

Article  CAS  PubMed  Google Scholar 

Anburajan P, Cayetano RD, Prohim YM, Thau NT, Kim S, Kim H et al (2023) Role of quorum sensing and quorum quenching in anaerobic digestion: A scoping review. Environ Res 239:117413. https://doi.org/10.1016/j.envres.2023.117413

Article  CAS  PubMed  Google Scholar 

Brilhante RSN, Costa AC, Pereira VS, Fernandes MR, de Oliveira JS, Rodrigues AM et al (2020) Antifungal activity of deferiprone and EDTA against Sporothrix spp.: effect on planktonic growth and biofilm formation. Med Mycol 59(6):537–544. https://doi.org/10.1093/mmy/myaa073

Article  CAS  Google Scholar 

Chen F, Gao Y, Chen X, Yu Z, Li X (2013) Quorum quenching enzymes and their application in degrading signal molecules to block quorum Sensing-Dependent infection. Int J Mol Sci 14(9):17477–17500. https://doi.org/10.3390/ijms140917477

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brackman G, Cos P, Maes L, Nelis Hans J, Coenye T (2011) Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo. Antimicrobial Agents and Chemotherapy 55(6):2655–2661. https://doi.org/10.1128/aac.00045-11

Yin L, Wang Y, Xiang S, Xu K, Wang B, Jia A-Q (2023) Tyramine, one quorum sensing inhibitor, reduces pathogenicity and restores Tetracycline susceptibility in Burkholderia cenocepacia. Biochem Pharmacol 218:115906. https://doi.org/10.1016/j.bcp.2023.115906

Article  CAS  PubMed  Google Scholar 

Guedes GMM, Freitas AS, Pinheiro RM, Pereira VC, Melgarejo CMA, de Araujo ES et al (2023) Antibiofilm activity of promethazine, Deferiprone, and Manuka honey in an ex vivo wound model. Lett Appl Microbiol 76(10). https://doi.org/10.1093/lambio/ovad119

Merkel D, Soffer S, Filanovsky K, Braester A, Fibach E, Dana MM et al (2018) Decreased Iron overload and oxidative stress in transfusion dependent patients with myelodysplastic syndromes (MDS) with the oral Iron chelator deferiprone. Blood 132(Supplement 1):4381–4381. https://doi.org/10.1182/blood-2018-99-115157

Article  Google Scholar 

Scott C, Arora G, Dickson K, Lehmann C (2021) Iron chelation in local infection. Molecules 26(1):189. https://doi.org/10.3390/molecules26010189

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borchers A, Pieler T (2010) Programming pluripotent precursor cells derived from Xenopus embryos to generate specific tissues and organs. Genes (Basel) 1(3):413–426. https://doi.org/10.3390/genes1030413

Article  CAS  PubMed  Google Scholar 

Lu L, Li M, Yi G, Liao L, Cheng Q, Zhu J et al (2022) Screening strategies for quorum sensing inhibitors in combating bacterial infections. J Pharm Anal 12(1):1–14. https://doi.org/10.1016/j.jpha.2021.03.009

Article  PubMed  Google Scholar 

Zhou J-W, Ruan L-Y, Chen H-J, Luo H-Z, Jiang H, Wang J-S et al (2019) Inhibition of quorum sensing and virulence in Serratia marcescens by Hordenine. J Agric Food Chem 67(3):784–795. https://doi.org/10.1021/acs.jafc.8b05922

Article  CAS  PubMed  Google Scholar 

Rogério MEF, Chaves HV, Pinto IR, de Sousa NA, Ribeiro KA, Monteiro DAM et al (2022) ADME-Tox prediction and molecular Docking studies of two lead flavonoids from the roots of Tephrosia Egregia Sandw and the gastroprotective effects of its root extract in mice. BIO Integr 3(2). https://doi.org/10.15212/bioi-2021-0035

Xu K-Z, Yin L-J, Ding Z-W, Wang Y-J, Jia A-Q (2024) YtnP: one novel quorum quenching enzyme from Bacillus amyloliquefaciens W11 inhibits biofilms and spoilage of white radish by Serratia marcescens. Lwt 198:116058. https://doi.org/10.1016/j.lwt.2024.116058

Article  CAS  Google Scholar 

Xiang S-L, Xu K-Z, Yin L-J, Jia A-Q (2024) An investigation of quorum sensing inhibitors against Bacillus cereus in the endophytic fungus Pithomyces Sacchari of the Laurencia Sp. Mar Drugs 22(4):161. https://doi.org/10.3390/md22040161

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiang S-L, Xu K-Z, Yin L-J, Rao Y, Wang B, Jia A-Q (2024) Dopamine, an exogenous quorum sensing signaling molecule or a modulating factor in Pseudomonas aeruginosa? Biofilm 8:100208. https://doi.org/10.1016/j.bioflm.2024.100208

Article  PubMed  PubMed Central  Google Scholar 

Yang X, Liu Y, Gan J, Xiao Z-X, Cao Y (2022) FitDock: protein–ligand Docking by template fitting. Brief Bioinform 23(3). https://doi.org/10.1093/bib/bbac087

Liu Y, Yang X, Gan J, Chen S, Xiao Z-X, Cao Y (2022) CB-Dock2: improved protein–ligand blind Docking by integrating cavity detection, Docking and homologous template fitting. Nucleic Acids Res 50(W1):W159–W164. https://doi.org/10.1093/nar/gkac394

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chadha J, Khullar L, Gulati P, Chhibber S, Harjai K (2024) Repurposing albendazole as a potent inhibitor of quorum sensing-regulated virulence factors in Pseudomonas aeruginosa: novel prospects of a classical drug. Microb Pathog 186:106468. https://doi.org/10.1016/j.micpath.2023.106468

Article  CAS  PubMed  Google Scholar 

Lamin A, Kaksonen AH, Cole IS, Chen X-B (2022) Quorum sensing inhibitors applications: A new prospect for mitigation of microbiologically influenced corrosion. Bioelectrochemistry 145:108050. https://doi.org/10.1016/j.bioelechem.2022.108050

Article  CAS  PubMed  Google Scholar 

Chen J, Wang B, Lu Y, Guo Y, Sun J, Wei B et al (2019) Quorum sensing inhibitors from marine microorganisms and their synthetic derivatives. Mar Drugs 17(2):80. https://doi.org/10.3390/md17020080

Article  CAS  PubMed