Pan-cancer analysis reveal that mA writer WTAP involve in tumor cell cycle regulation and tumor immunity

Zhao BS, Roundtree IA, He C. Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 2017;18(1):31–42.

CAS  PubMed  Google Scholar 

Lence T, Akhtar J, Bayer M, Schmid K, Spindler L, Ho CH, Kreim N, Andrade-Navarro MA, Poeck B, Helm M, Roignant JY. m(6)A modulates neuronal functions and sex determination in Drosophila. Nature. 2016;540(7632):242–7.

CAS  PubMed  Google Scholar 

Wu Y, Zhou C, Yuan Q. Role of DNA and RNA N6-adenine methylation in regulating stem cell fate. Curr Stem Cell Res Ther. 2018;13(1):31–8.

CAS  PubMed  Google Scholar 

Hou J, Zhang H, Liu J, Zhao Z, Wang J, Lu Z, Hu B, Zhou J, Zhao Z, Feng M, et al. YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma. Mol Cancer. 2019;18(1):163.

PubMed  PubMed Central  Google Scholar 

Wang Q, Chen C, Ding Q, Zhao Y, Wang Z, Chen J, Jiang Z, Zhang Y, Xu G, Zhang J, et al. METTL3-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Gut. 2020;69(7):1193–205.

CAS  PubMed  Google Scholar 

Li Z, Peng Y, Li J, Chen Z, Chen F, Tu J, Lin S, Wang H. N(6)-methyladenosine regulates glycolysis of cancer cells through PDK4. Nat Commun. 2020;11(1):2578.

CAS  PubMed  PubMed Central  Google Scholar 

Huang H, Weng H, Chen J. m(6)A modification in coding and non-coding RNAS: roles and therapeutic implications in cancer. Cancer Cell. 2020;37(3):270–88.

CAS  PubMed  PubMed Central  Google Scholar 

Barranco C. Viral infection linked to m6A alterations in host mRNAs. Nat Rev Mol Cell Biol. 2020;21(2):64–5.

CAS  PubMed  Google Scholar 

Wang T, Kong S, Tao M, Ju S. The potential role of RNA N6-methyladenosine in cancer progression. Mol Cancer. 2020;19(1):88.

CAS  PubMed  PubMed Central  Google Scholar 

Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, Yang C, Chen Y. The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther. 2021;6(1):74.

CAS  PubMed  PubMed Central  Google Scholar 

Ping X-L, Sun B-F, Wang L, Xiao W, Yang X, Wang W-J, Adhikari S, Shi Y, Lv Y, Chen Y-S, et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 2014;24(2):177–89.

CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 2014;10(2):93–5.

CAS  PubMed  Google Scholar 

Little NA, Hastie ND, Davies RC. Identification of WTAP, a novel Wilms’ tumour 1-associating protein. Hum Mol Genet. 2000;9(15):2231–9.

CAS  PubMed  Google Scholar 

Xi Z, Xue Y, Zheng J, Liu X, Ma J, Liu Y. WTAP Expression predicts poor prognosis in malignant glioma patients. J Mol Neurosci. 2016;60(2):131–6.

CAS  PubMed  Google Scholar 

Yu HL, Ma XD, Tong JF, Li JQ, Guan XJ, Yang JH. WTAP is a prognostic marker of high-grade serous ovarian cancer and regulates the progression of ovarian cancer cells. Onco Targets Ther. 2019;12:6191–201.

CAS  PubMed  PubMed Central  Google Scholar 

Tang J, Wang F, Cheng G, Si S, Sun X, Han J, Yu H, Zhang W, Lv Q, Wei JF, Yang H. Wilms’ tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability. J Exp Clin Cancer Res. 2018;37(1):40.

PubMed  PubMed Central  Google Scholar 

Lei J, Fan Y, Yan C, Jiamaliding Y, Tang Y, Zhou J, Huang M, Ju G, Wu J, Peng C. Comprehensive analysis about prognostic and immunological role of WTAP in pan-cancer. Front Genet. 2022;13:1007696.

CAS  PubMed  PubMed Central  Google Scholar 

Yan X, Liu F, Yan J, Hou M, Sun M, Zhang D, Gong Z, Dong X, Tang C, Yin P. WTAP-VIRMA counteracts dsDNA binding of the m6A writer METTL3-METTL14 complex and maintains N6-adenosine methylation activity. Cell Discov. 2023;9(1):100.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui X-L, Zou Z, et al. A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling. Mol Cell. 2023;83:15.

Google Scholar 

Feng Z-Y, Wang T, Su X, Guo S. Identification of the m6A RNA Methylation Regulators WTAP as a novel prognostic biomarker and genomic alterations in cutaneous melanoma. Front Mol Biosci. 2021;8: 665222.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Kang M, Zhang B, Meng F, Song J, Kaneko H, Shimamoto F, Tang B. m(6)A modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5. Mol Cancer. 2019;18(1):185.

CAS  PubMed  PubMed Central  Google Scholar 

Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411(6835):342–8.

CAS  PubMed  Google Scholar 

Phan TG, Croucher PI. The dormant cancer cell life cycle. Nat Rev Cancer. 2020;20(7):398–411.

CAS  PubMed  Google Scholar 

Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, et al. Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018;20(3):285–95.

CAS  PubMed  PubMed Central  Google Scholar 

Hirayama M, Wei FY, Chujo T, Oki S, Yakita M, Kobayashi D, Araki N, Takahashi N, Yoshida R, Nakayama H, Tomizawa K. FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression. Cell Rep. 2020;31(1): 107464.

CAS  PubMed  Google Scholar 

Lou X, Ning J, Liu W, Li K, Qian B, Xu D, Wu Y, Zhang D, Cui W. YTHDF1 Promotes Cyclin B1 Translation through m(6)A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation. Cells. 2021;10:7.

Google Scholar 

Wang XK, Zhang YW, Wang CM, Li B, Zhang TZ, Zhou WJ, Cheng LJ, Huo MY, Zhang CH, He YL. METTL16 promotes cell proliferation by up-regulating cyclin D1 expression in gastric cancer. J Cell Mol Med. 2021;25(14):6602–17.

CAS  PubMed  PubMed Central  Google Scholar 

Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, et al. m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature. 2017;548(7667):338–42.

CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X. Mettl3-mediated mRNA m(6)A methylation promotes dendritic cell activation. Nat Commun. 2019;10(1):1898.

PubMed  PubMed Central  Google Scholar 

Zhang B, Wu Q, Li B, Wang D, Wang L, Zhou YL. m(6)A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer. Mol Cancer. 2020;19(1):53.

CAS  PubMed  PubMed Central  Google Scholar 

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