Davidovitch Z (1991) Tooth movement. Crit Rev Oral Biol Med 2:411–450. https://doi.org/10.1177/10454411910020040101

Article  CAS  PubMed  Google Scholar 

Kaneda T, Miyauchi M, Takekoshi T, Kitagawa S, Kitagawa M, Shiba H, Kurihara H, Takata T (2006) Characteristics of periodontal ligament subpopulations obtained by sequential enzymatic digestion of rat molar periodontal ligament. Bone 38:420–426. https://doi.org/10.1016/j.bone.2005.08.021

Article  CAS  PubMed  Google Scholar 

Kanzaki H, Chiba M, Shimizu Y, Mitani H (2002) Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res 17:210–220. https://doi.org/10.1359/jbmr.2002.17.2.210

Article  CAS  PubMed  Google Scholar 

Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H (2004) Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. J Dent Res 83:920–925. https://doi.org/10.1177/154405910408301206

Article  CAS  PubMed  Google Scholar 

Harrel SK (2000) (2003) Occlusal forces as a risk factor for periodontal disease. Periodontol 32:111–117. https://doi.org/10.1046/j.0906-6713.2002.03209.x

Article  Google Scholar 

Lerner UH (2006) Inflammation-induced Bone Remodeling in Periodontal Disease and the Influence of post-menopausal Osteoporosis. J Dent Res 85:596–607. https://doi.org/10.1177/154405910608500704

Article  CAS  PubMed  Google Scholar 

Mayahara K, Yamaguchi A, Takenouchi H, Kariya T, Taguchi H, Shimizu N (2012) Osteoblasts stimulate osteoclastogenesis via RANKL expression more strongly than periodontal ligament cells do in response to PGE(2). Arch Oral Biol 57:1377–1384. https://doi.org/10.1016/j.archoralbio.2012.07.009

Article  CAS  PubMed  Google Scholar 

Jiang C, Li Z, Quan H, Xiao L, Zhao J, Jiang C, Wang Y, Liu J, Gou Y, An S, Huang Y, Yu W, Zhang Y, He W, Yi Y, Chen Y, Wang J (2015) Osteoimmunology in orthodontic tooth movement. Oral Dis 21:694–704. https://doi.org/10.1111/odi.12273

Article  CAS  PubMed  Google Scholar 

Shoji-Matsunaga A, Ono T, Hayashi M, Takayanagi H, Moriyama K, Nakashima T (2017) Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression. Sci Rep 7:8753. https://doi.org/10.1038/s41598-017-09326-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chukkapalli SS, Lele TP (2018) Periodontal Cell Mechanotransduction. Open Biol 8:180053. https://doi.org/10.1098/rsob.180053

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rath-Deschner B, Nogueira AVB, Beisel-Memmert S, Nokhbehsaim M, Eick S, Cirelli JA, Deschner J, Jager A, Damanaki A (2022) Interaction of periodontitis and orthodontic tooth movement-an in vitro and in vivo study. Clin Oral Investig 26:171–181. https://doi.org/10.1007/s00784-021-03988-4

Article  PubMed  Google Scholar 

Klein Y, Fleissig O, Polak D, Barenholz Y, Mandelboim O, Chaushu S (2020) Immunorthodontics: in vivo gene expression of orthodontic tooth movement. Sci Rep 10:8172. https://doi.org/10.1038/s41598-020-65089-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson DM, Arredondo J, Hahn K, Valente G, Martin JF, Wilson-Rawls J, Rawls A (2006) Mohawk is a novel homeobox gene expressed in the developing mouse embryo. Dev Dyn 235:792–801. https://doi.org/10.1002/dvdy.20671

Article  CAS  PubMed  Google Scholar 

Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H (2010) The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proc Natl Acad Sci U S A 107:10538–11054. https://doi.org/10.1073/pnas.1000525107

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R (2010) The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Mol Cell Biol 30:4797–4807. https://doi.org/10.1128/mcb.00207-10

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakamichi R, Nonoyama T, Chiba T, Kurimoto R, Ohzono H, Olmer M, Shukunami C, Fuku N, Wang G, Morrison E, Pitsiladis YP, Ozaki T, D’Lima D, Lotz M, Patapoutian A, Asahra H (2022) The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Sci Transl Med 14:647. https://doi.org/10.1126/scitranslmed.abj5557

Article  CAS  Google Scholar 

Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H (2017) The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament. Development 144:313–320. https://doi.org/10.1242/dev.135798

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakamichi R, Kataoka K, Asahara H (2018) Essential role of Mohawk for tenogenic tissue homeostasis including spinal disc and periodontal ligament. Mod Rheumatol 28:933–940. https://doi.org/10.1080/14397595.2018.1466644

Article  PubMed  PubMed Central  Google Scholar 

Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H (2016) Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis. Proc Natl Acad Sci U S A 113:7840–7845. https://doi.org/10.1073/pnas.1522054113

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyazaki T, Kurimoto R, Chiba T, Matsushima T, Nakamichi R, Tsutsumi H, Takada K, Yagasaki L, Kato T, Shishido K, Kobayashi Y, Matsumoto T, Moriyama K, Asahara H (2021) Mkx regulates the orthodontic tooth movement via osteoclast induction. J Bone Miner Metab 39:780–786. https://doi.org/10.1007/s00774-021-01233-2

Article  CAS  PubMed  Google Scholar 

Yagasaki L, Chiba T, Kurimoto R, Nakajima M, Iwata T, Asahara H (2024) The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum. Regen Ther 25:186–193. https://doi.org/10.1016/j.reth.2023.12.007

Article  CAS  PubMed  Google Scholar 

Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, Srivastava A, Molla G, Madad S, Fernandez-Granda C, Satija R (2024) Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat Biotechnol 42:293–304. https://doi.org/10.1038/s41587-023-01767-y

Article  CAS  PubMed  Google Scholar 

Mihara E, Watanabe S, Bashiruddin NK, Nakamura N, Matoba K, Sano Y, Maini R, Yin Y, Sakai K, Arimori T, Matsumoto K, Suga H, Takagi J (2021) Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins. Nat Commun 12:154. https://doi.org/10.1038/s41467-021-21875-0

Article  CAS  Google Scholar 

Natali AN, Pavan PG, Scarpa C (2004) Numerical analysis of tooth mobility: formulation of a non-linear constitutive law for the periodontal ligament. Dent Mater 20:623–629. https://doi.org/10.1016/j.dental.2003.08.003

Article  PubMed  Google Scholar 

Rath-Deschner B, Deschner J, Reimann S, Jager A, Gotz W (2009) Regulatory effects of biomechanical strain on the insulin-like growth factor system in human periodontal cells. J Biomech 42:2584–2589. https://doi.org/10.1016/j.jbiomech.2009.07.013

Article  PubMed  Google Scholar 

Safi IN, Mohammed Ali Hussein B, Al-Shammari AM (2019) In vitro periodontal ligament cell expansion by co-culture method and formation of multi-layered periodontal ligament-derived cell sheets. Regen Ther 11:225–239. https://doi.org/10.1016/j.reth.2019.08.002

Article  PubMed  PubMed Central  Google Scholar 

Takada K, Chiba T, Miyazaki T, Yagasaki L, Nakamichi R, Iwata T, Moriyama K, Harada H, Asahara H (2022) Single Cell RNA sequencing reveals critical functions of Mkx in periodontal ligament homeostasis. Front Cell Dev Biol 10:795441. https://doi.org/10.3389/fcell.2022.795441

Article