Behroozi Z, Ramezani F, Janzadeh A, Rahimi B, Nasirinezhad F. Platelet-rich plasma in umbilical cord blood reduces neuropathic pain in spinal cord injury by altering the expression of ATP receptors. Physiol Behav. 2021;228:113186.

Article  CAS  PubMed  Google Scholar 

Saffarpour S, Janzadeh A, Rahimi B, Ramezani F, Nasirinezhad F. Chronic nanocurcumin treatment ameliorates pain-related behavior, improves spatial memory, and reduces hippocampal levels of IL-1β and TNFα in the chronic constriction injury model of neuropathic pain. Psychopharmacology (Berl). 2021;238:877–86.

Article  CAS  Google Scholar 

Sharifi A, Zandieh A, Behroozi Z, Hamblin MR, Mayahi S, Yousefifard M, et al. Sustained delivery of chABC improves functional recovery after a spine injury. BMC Neurosci. 2022;23:60.

Article  CAS  PubMed Central  Google Scholar 

Behroozi Z, Rahimi B, Hamblin MR, Nasirinezhad F, Janzadeh A, Ramezani F. Injection of cerium oxide nanoparticles to treat spinal cord injury in rats. J Neuropathol Exp Neurol. 2022;81:635–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Niles LP, Armstrong KJ, Rincón Castro LM, Dao CV, Sharma R, McMillan CR, et al. Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers. BMC Neurosci. 2004;5:41.

Article  Google Scholar 

Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L, et al. Melatonin’s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules. 2020;10:1211.

Article  CAS  PubMed Central  Google Scholar 

Kilic E, Ozdemir YG, Bolay H, Keleştimur H, Dalkara T. Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J. Cereb Blood Flow Metab. 1999;19:511–6.

Article  CAS  PubMed  Google Scholar 

Biran V, Phan Duy A, Decobert F, Bednarek N, Alberti C, Baud O. Is melatonin ready to be used in preterm infants as a neuroprotectant? Dev Med Child Neurol. 2014;56:717–23.

Article  Google Scholar 

Pei Z, Pang SF, Cheung RT. Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Stroke. 2003;34:770–5.

Article  CAS  Google Scholar 

Sinha K, Degaonkar MN, Jagannathan NR, Gupta YK. Effect of melatonin on ischemia reperfusion injury induced by middle cerebral artery occlusion in rats. Eur J Pharmacol. 2001;428:185–92.

Article  CAS  PubMed  Google Scholar 

Aydemir S, Dogan D, Kocak A, Dilsiz N. The effect of melatonin on spinal cord after ischemia in rats. Spinal Cord. 2016;54:360–3.

Article  CAS  Google Scholar 

Shen Z, Zhou Z, Gao S, Guo Y, Gao K, Wang H, et al. Melatonin inhibits neural cell apoptosis and promotes locomotor recovery via activation of the Wnt/β-catenin signaling pathway after spinal cord injury. Neurochem Res. 2017;42:2336–43.

Article  CAS  PubMed  Google Scholar 

Li Y, Guo Y, Fan Y, Tian H, Li K, Mei X. Melatonin Enhances autophagy and reduces apoptosis to promote locomotor recovery in spinal cord injury via the PI3K/AKT/mTOR signaling pathway. Neurochem Res. 2019;44:2007–19.

Article  CAS  Google Scholar 

Majidpoor J, Khezri Z, Rostamzadeh P, Mortezaee K, Rezaie MJ, Fathi F, et al. The expressions of NLRP1, NLRP3, and AIM2 inflammasome complexes in the contusive spinal cord injury rat model and their responses to hormonal therapy. Cell Tissue Res. 2020;381:397–410.

Article  CAS  Google Scholar 

Nesic O, Lee J, Unabia GC, Johnson K, Ye Z, Vergara L, et al. Aquaporin 1 - a novel player in spinal cord injury. J Neurochem. 2008;105:628–40.

Article  CAS  PubMed Central  Google Scholar 

Guízar-Sahagún G, Rodríguez-Balderas CA, Franco-Bourland RE, Martínez-Cruz A, Grijalva I, Ibarra A, et al. Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. Spinal Cord. 2009;47:156–60.

Article  PubMed  Google Scholar 

Arya S, Kaji AH, Boermeester MA. PRISMA reporting guidelines for meta-analyses and systematic reviews. JAMA Surg. 2021;156:789–90.

Article  PubMed  Google Scholar 

Gale K, Kerasidis H, Wrathall JR. Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment. Exp Neurol. 1985;88:123–34.

Article  CAS  Google Scholar 

Ahmadi S, Rabiee N, Fatahi Y, Hooshmand SE, Bagherzadeh M, Rabiee M, et al. Green chemistry and coronavirus. Sustain Chem Pharm. 2021;21:100415.

Article  CAS  PubMed Central  Google Scholar 

Gao K, Niu J, Dang X. Neuroprotection of melatonin on spinal cord injury by activating autophagy and inhibiting apoptosis via SIRT1/AMPK signaling pathway. Biotechnol Lett. 2020;42:2059–69.

Article  CAS  PubMed  Google Scholar 

Bi J, Shen J, Chen C, Li Z, Tan H, Sun P et al. Role of melatonin in the dynamics of acute spinal cord injury in rats. J Cell Mol Med. 2021;25:2909–17.

Wei L, Huang Y, Chen Y, Wu J, Chen K, Zheng Z, et al. Biomarkers for predicting the severity of spinal cord injury by proteomic analysis. Front Mol Neurosci. 2023;16:1153230.

Article  CAS  PubMed Central  Google Scholar 

Park S, Lee SK, Park K, Lee Y, Hong Y, Lee S et al. Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury. J Pineal Res. 2012;52:107-19.

Esposito E, Genovese T, Caminiti R, Bramanti P, Meli R, Cuzzocrea S. Melatonin regulates matrix metalloproteinases after traumatic experimental spinal cord injury. J Pineal Res. 2008;45:149–56.

Article  CAS  PubMed  Google Scholar 

Yang L, Yao M, Lan Y, Mo W, Sun Y-L, Wang J, et al. Melatonin for spinal cord injury in animal models: a systematic review and network meta-analysis. J Neurotrauma. 2016;33:290–300.

Article  Google Scholar 

Jing Y, Yang D, Bai F, Zhang C, Qin C, Li D, et al. Melatonin treatment alleviates spinal cord injury-induced gut dysbiosis in mice. J Neurotrauma. 2019;36:2646–64.

Article  Google Scholar 

Esposito E, Genovese T, Caminiti R, Bramanti P, Meli R, Cuzzocrea S. Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury. J Pineal Res. 2009;46:79–86.

Article  CAS  PubMed  Google Scholar 

Fakhri S, Kiani A, Jalili C, Abbaszadeh F, Piri S, Farzaei MH et al. Intrathecal administration of melatonin ameliorates the neuroinflammation-mediated sensory and motor dysfunction in a rat model of compression spinal cord injury. Curr Mol Pharmacol. 2020.

Lee Y, Lee S, Lee SR, Park K, Hong Y, Lee M, et al. Beneficial effects of melatonin combined with exercise on endogenous neural stem/progenitor cells proliferation after spinal cord injury. Int J Mol Sci. 2014;15:2207–22.

Article  PubMed Central  Google Scholar 

Schiaveto-de-Souza A, da-Silva CA, Defino HL, Del Bel EA. Effect of melatonin on the functional recovery from experimental traumatic compression of the spinal cord. Braz J Med Biol Res. 2013;46:348–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu G, Shi D, Zhi Z, Ao R, Yu B. Melatonin ameliorates spinal cord injury by suppressing the activation of inflammasomes in rats. J Cell Biochem. 2019;120:5183–92.

Article  CAS  PubMed  Google Scholar 

Yang Z, Bao Y, Chen W, He Y. Melatonin exerts neuroprotective effects by attenuating astro- and microgliosis and suppressing inflammatory response following spinal cord injury. Neuropeptides. 2020;79:102002.

Article  PubMed  Google Scholar 

Akakin D, Kiran D, Ozkan N, Erşahin M, Ozdemir-Kumral ZN, Yeğen B, et al. Protective effects of melatonin against spinal cord injury induced oxidative damage in rat kidney: a morphological and biochemical study. Acta Histochem. 2013;115:827–34.

Article  CAS  Google Scholar 

Guo Y, Zhang P, Zhao H, Xu C, Lin S, Mei X, et al. Melatonin promotes microglia toward anti-inflammatory phenotype after spinal cord injury. Int Immunopharmacol. 2023;114:109599.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Liu ZJ, Zhang WX, Wu QC, Zhang YJ, Liu YD, et al. Melatonin improves functional recovery in female rats after acute spinal cord injury by modulating polarization of spinal microglial/macrophages. J Neurosci Res. 2019;97:733–43.

Fee DB, Swartz KR, Scheff N, Roberts K, Gabbita P, Scheff S. Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury. Brain Res. 2010;1340:81–5.

Article  CAS  PubMed