Comparing clinical, laboratory, and epidemiological features of COVID-19 variants during different pandemic waves among children in Ukraine

World Health Organization (WHO). Coronavirus Disease (COVID-19) Situation Reports. Geneva: World Health Organization; 2020. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public?adgroupsurvey=&gclid=CjwKCAiA-vOsBhAAEiwAIWR0Ta3u9u4X1Dzz03Op0gvuk9DG9f8LLHLk8GPHMILN9k2nAl7FHAUDiRoCuSQQAvD_BwE

Wu L, Zhang XF, Yang Y, Yi XY, Jiang XP, Han HY, et al. Clinical Characteristics of Pediatric Cases of COVID-19 in Hunan, China: A Retrospective, Multi-Center Case Series. Front Pediatr. 2021;9:665377. DOI: https://doi.org/10.3389/fped.2021.665377

Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109:1088-95. DOI: https://doi.org/10.1111/apa.15270

United Nations International Children’s Emergency Fund (UNICEF). Child survival.

Available from: https://data.unicef.org/topic/child-survival/covid-19/

Qi K, Zeng W, Ye M, Zheng L, Song C, Hu S, et al. Clinical, laboratory, and imaging features of pediatric COVID-19: A systematic review and meta-analysis. Medicine (Baltimore). 2021;100:e25230. DOI: https://doi.org/10.1097/MD.0000000000025230

Antypkin, Yu G., Lapshyn, V.F., Umanets, T.R., Kaminska, T.M., Banadyha, N.V., Koloskova, ?.?., et al. Analysis of the COVID-19 prevalence among children in Ukraine during the first year of the pandemic. CHILD`S HEALTH. 2023;18:1-5. DOI: https://doi.org/10.22141/2224-0551.18.1.2023.1551

Makulo JR, Wumba R, Mandina MN, Mbala P, Aziza AA, Nlandu YM, et al. SARS-CoV2 mutations and impact on mortality: observational study in a sub-saharan Africa hospital. Virol J. 2023;2056. DOI: https://doi.org/10.1186/s12985-023-02014-1

Callaway E. Coronavirus variants get Greek names - but will scientists use them? Nature. 2021;594:162. DOI: https://doi.org/10.1038/d41586-021-01483-0

Mahilkar S, Agrawal S, Chaudhary S, Parikh S, Sonkar SC, Verma DK, et al. SARS-CoV-2 variants: Impact on biological and clinical outcome. Front Med (Lausanne). 2022;9:995960. DOI: https://doi.org/10.3389/fmed.2022.995960

Chatterjee S, Bhattacharya M, Nag S, Dhama K, Chakraborty C. A Detailed Overview of SARS-CoV-2 Omicron: Its Sub-Variants, Mutations and Pathophysiology, Clinical Characteristics, Immunological Landscape, Immune Escape, and Therapies. Viruses. 2023;15:167. DOI: https://doi.org/10.3390/v15010167

Parums DV. Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread. Med Sci Monit. 2023;29:e939580. DOI: https://doi.org/10.12659/MSM.939580

Gankin Y, Nemira A, Koniukhovskii V, Chowell G, Weppelmann TA, Skums P, et al.Investigating the first stage of the COVID-19 pandemic in Ukraine using epidemiological and genomic data. Infect Genet Evol. 2021;95:105087. DOI: https://doi.org/10.1016/j.meegid.2021.105087

Centers for Disease Control and Prevention (CDC). Child Development Basics. Available from: https://www.cdc.gov/ncbddd/childdevelopment/positiveparenting/index.html

Raniszewska A, Górska E, Kotu?a I, Stelmaszczyk-Emmel A, Popko K, Ciepiela O. Recurrent respiratory tract infections in children - analysis of immunological examinations. Cent Eur J Immunol. 2015;40:167–73. DOI: https://doi.org/10.5114/ceji.2015.52830

Marks KJ, Whitaker M, Agathis NT, Anglin O, Milucky J, Patel K, et al. COVID-NET Surveillance Team. Hospitalization of Infants and Children Aged 0-4 Years with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 2020-February 2022. MMWR Morb Mortal Wkly Rep. 2022;71:429-36. DOI: https://doi.org/10.15585/mmwr.mm7111e2

Nyberg T, Ferguson NM, Nash SG, Webster HH, Flaxman S, Andrews N, et al. Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study. Lancet. 2022;399:1303-12. DOI: https://doi.org/10.1016/S0140-6736(22)00462-7

Han MS, Kim KM, Oh KJ, Chang JY, Lee SY, Choi JE, et al; Distinct Clinical and Laboratory Features of COVID-19 in Children During the Pre-Delta, Delta and Omicron Wave. Pediatr Infect Dis J. 2023;42:423-28. DOI: https://doi.org/10.1097/INF.0000000000003872

Shi DS, Whitaker M, Marks KJ, Anglin O, Milucky J, Patel K, et al. Hospitalizations of Children Aged 5-11 Years with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 2020-February 2022. MMWR Morb Mortal Wkly Rep. 2022;71:574-81. DOI: https://doi.org/10.15585/mmwr.mm7116e1

Allen H, Vusirikala A, Flannagan J, Twohig KA, Zaidi A, Chudasama D, et al. Household transmission of COVID-19 cases associated with SARS-CoV-2 delta variant (B.1.617.2): national case-control study. Lancet Reg Health Eur. 2022;12:100252. DOI: https://doi.org/10.1016/j.lanepe.2021.100252

Di Chiara C, Boracchini R, Sturniolo G, Barbieri A, Costenaro P, Cozzani S, et al. Clinical features of COVID-19 in Italian outpatient children and adolescents during Parental, Delta, and Omicron waves: a prospective, observational, cohort study. Front Pediatr. 2023;11:1193857. DOI: https://doi.org/10.3389/fped.2023.1193857

Harashchenko T, Umanets T, Podolskiy V, Kaminska T, Marushko Y, Podolskiy V, et al. Epidemiological, Clinical, and Laboratory Features of Children with SARS-CoV-2 in Ukraine. J Mother Child. 2023;27:33-41. DOI: https://doi.org/10.34763/jmotherandchild.20232701.d-23-00012

Jelic M, Silveira L, Lang S, Curran-Hays S, Boyer S, Carter B, et al. Children and COVID-19 in Colorado study. Changing Characteristics of Children With COVID-19 in Colorado Admitted During Different Variant Periods. Pediatr Infect Dis J. 2023;42:679-84. DOI: https://doi.org/10.1097/INF.0000000000003944

Mayo Clinic. Febrile seizure. Available from: https://www.mayoclinic.org/diseases-conditions/febrile-seizure/symptoms-causes/syc-20372522

Cloete J, Kruger A, Masha M, du Plessis NM, Mawela D, Tshukudu M, et al. Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study. Lancet Child Adolesc Health. 2022;6:294-302. DOI: https://doi.org/10.1016/S2352-4642(22)00027-X

Ikuse T, Aizawa Y, Yamanaka T, Hasegawa S, Hayashi T, Tamura T, et al. Comparison of Clinical Characteristics of Children Infected With Coronavirus Disease 2019 Between Omicron Variant BA.5 and BA.1/BA.2 in Japan. Pediatr Infect Dis J. 2023;42:503-9. DOI: https://doi.org/10.1097/INF.0000000000003894

Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R, et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci. 2021;24:168-75. DOI: https://doi.org/10.1038/s41593-020-00758-5

Burks SM, Rosas-Hernandez H, Alejandro Ramirez-Lee M, Cuevas E, Talpos JC. Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? Brain Behav Immun. 2021;95:7-14. DOI: https://doi.org/10.1016/j.bbi.2020.12.031

Nori W, Ghani Zghair MA. Omicron targets upper airways in pediatrics, elderly and unvaccinated population. World J Clin Cases. 2022;10:12062-5. DOI: https://doi.org/10.12998/wjcc.v10.i32.12062

Jiang J, Yang M, Li DY, Qiao LN, Zhang HY. ????Omicron?????????????? [Clinical characteristics of children with Omicron variant infection in Chengdu area, China]. Zhongguo Dang Dai Er Ke Za Zhi. 2023;25:849-54. Chinese. DOI: https://doi.org/10.7499/j.issn.1008-8830.2302147

Dhawan M, Sharma A, Priyanka, Thakur N, Rajkhowa TK, Choudhary OP. Delta variant (B.1.617.2) of SARS-CoV-2: Mutations, impact, challenges and possible solutions. Human Vaccines & Immunotherapeutics. 2022;18:2068883. DOI: https://doi.org/10.1080/21645515.2022.2068883

Samieefar N, Rashedi R, Akhlaghdoust M, Mashhadi M, Darzi P, Rezaei N. Delta Variant: The New Challenge of COVID-19 Pandemic, an Overview of Epidemiological, Clinical, and Immune Characteristics. Acta Biomed. 2022;93:e2022179. DOI: https://doi.org/10.23750/abm.v93i1.12210

Lee FE, Walsh EE, Falsey AR, Lumb ME, Okam NV, Liu N, et al; Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection. J Infect Dis. 2007;195:1779-88. DOI: https://doi.org/10.1086/518249

Zheng SY, Xiao QY, Xie XH, Deng Y, Ren L, Tian DY, et al. Association between secondary thrombocytosis and viral respiratory tract infections in children. Sci Rep. 2016;6:22964. DOI: https://doi.org/10.1038/srep22964

Vassallo M, Manni S, Klotz C, Fabre R, Pini P, Blanchouin E, et al. Patients Admitted for Variant Alpha COVID-19 Have Poorer Outcomes than Those Infected with the Old Strain. J Clin Med. 2021;10:3550. DOI: https://doi.org/10.3390/jcm10163550

Yadav D, Chandra J, Sharma S, Singh V. Clinicohematological study of thrombocytosis. Indian J Pediatr. 2010;77:643-7. DOI: https://doi.org/10.1007/s12098-010-0091-4

Gürsoy B, Sürmeli CD, Alkan M, Sat?c? C, Altunok ES, Kamat S, et al. Cytokine storm in severe COVID-19 pneumonia. J Med Virol. 2021;93:5474-80. DOI: https://doi.org/10.1002/jmv.27068

Chen YE, Ren FL, Gu X, Zhang HJ, Li WJ, Yang H, Shang FQ. Clinical Value of Platelets and Coagulation Parameters in Predicting the Severity of Delta Variant SARS-CoV-2. Pathobiology. 2023;90:241-50. DOI: https://doi.org/10.1159/000528318

Gilbert DN. Procalcitonin as a biomarker in respiratory tract infection. Clin Infect Dis.2011;52:S346-50. DOI: https://doi.org/10.1093/cid/cir050

Devaux CA, Rolain JM, Raoult D. ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome. J Microbiol Immunol Infect. 2020;53:425-35. DOI: https://doi.org/10.1016/j.jmii.2020.04.015.

Warner FJ, Rajapaksha H, Shackel N, Herath CB. ACE2: from protection of liver disease to propagation of COVID-19. Clin Sci (Lond). 2020;134:3137-58. DOI: https://doi.org/10.1042/CS20201268

Cicho?-Lach H, Michalak A. Liver injury in the era of COVID-19. World J Gastroenterol. 2021;27:377-90. DOI: https://doi.org/10.3748/wjg.v27.i5.377

Lin L, Liu Y, Tang X, He D. The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern. Front Public Health. 2021;9:775224. DOI: https://doi.org/10.3389/fpubh.2021.775224

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