Marchetti O, Bille J, Fluckiger U, Eggimann P, Ruef C, Garbino J, et al. Epidemiology of Candidemia in Swiss Tertiary Care hospitals: secular trends, 1991–2000. Clin Infect Dis. 2004;38:311–20.
Guinea J. Global trends in the distribution of Candida species causing candidemia. Clin Microbiol Infect. 2014;20:5–10.
Lortholary O, Renaudat C, Sitbon K, Madec Y, Denoeud-Ndam L, Wolff M, et al. Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002–2010). Intensive Care Med. 2014;40:1303–12.
Article PubMed PubMed Central Google Scholar
Magill SS, O’Leary E, Janelle SJ, Thompson DL, Dumyati G, Nadle J, et al. Changes in prevalence of Health Care–Associated infections in U.S. hospitals. N Engl J Med. 2018;379:1732–44.
Article PubMed PubMed Central Google Scholar
Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice Guideline for the management of Candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis off Publ Infect Dis Soc Am. 2016;62:e1–50.
Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O, et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect. 2012;18:19–37.
Article CAS PubMed Google Scholar
Liu J, Balasubramanian MK. 1,3-beta-glucan synthase: a useful target for antifungal drugs. Curr Drug Targets - Infect Disord. 2001;1:159–69.
Article CAS PubMed Google Scholar
Denning DW. Echinocandin antifungal drugs. LANCET. 2003;362.
Dowell JA, Knebel W, Ludden T, Stogniew M, Krause D, Henkel T. Population Pharmacokinetic Analysis of Anidulafungin, an Echinocandin Antifungal. J Clin Pharmacol. 2004;44:590–8.
Article CAS PubMed Google Scholar
Andes D, Diekema DJ, Pfaller MA, Bohrmuller J, Marchillo K, Lepak A. Vivo comparison of the pharmacodynamic targets for Echinocandin drugs against Candida Species. Antimicrob Agents Chemother. 2010;54:2497–506.
Article CAS PubMed PubMed Central Google Scholar
Andes D, Diekema DJ, Pfaller MA, Prince RA, Marchillo K, Ashbeck J, et al. In vivo pharmacodynamic characterization of Anidulafungin in a neutropenic murine candidiasis model. Antimicrob Agents Chemother. 2008;52:539–50.
Article CAS PubMed Google Scholar
Damle BD, Dowell JA, Walsky RL, Weber GL, Stogniew M, Inskeep PB. In Vitro and in vivo studies to characterize the Clearance mechanism and potential cytochrome P450 interactions of Anidulafungin. Antimicrob Agents Chemother. 2009;53:1149–56.
Article CAS PubMed Google Scholar
Abdul-Aziz MH, Alffenaar J-WC, Bassetti M, Bracht H, Dimopoulos G, Marriott D, et al. Antimicrobial therapeutic drug monitoring in critically ill adult patients: a position Paper#. Intensive Care Med. 2020;46:1127–53.
Article PubMed PubMed Central Google Scholar
Liu X, Liu D, Pan Y, Li Y. Pharmacokinetic/pharmacodynamics variability of echinocandins in critically ill patients: a systematic review and meta-analysis. J Clin Pharm Ther. 2020;45:1207–17.
Article CAS PubMed PubMed Central Google Scholar
Alsowaida YS, Alamer A, Thabit AK, Almulhim AS, Aleissa MM, Kalbasi A, et al. Echinocandin exposures in obese patients: a scoping review and clinical perspectives. Am J Health Syst Pharm. 2023;80:503–17.
Levey AS, Stevens LA, Schmid CH, Zhang Y (Lucy), Castro AF, Feldman HI A New Equation to Estimate Glomerular Filtration Rate, et al. editors. Ann Intern Med. 2009;150:604–12.
Anidulafungin. EUCAST rationale document.
Guideline on the use of pharmacokinetics and pharmacodynamics in the development of antimicrobial medicinal products. [cited 2023 Jul 21]; https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-use-pharmacokinetics-pharmacodynamics-development-antimicrobial-medicinal-products_en.pdf
Nahm FS. Receiver operating characteristic curve: overview and practical use for clinicians. Korean J Anesthesiol. 2022;75:25–36.
Article PubMed PubMed Central Google Scholar
Wickham H. The tidyverse [Internet]. Presentation. 2016. Available from: http://tidyverse.org
Grolemund HW. and G. Welcome| R for Data Science [Internet]. [cited 2023 Jan 11]. https://r4ds.had.co.nz/
Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez J-C, et al. pROC: an open-source package for R and S + to analyze and compare ROC curves. BMC Bioinformatics. 2011;12:77.
Article PubMed PubMed Central Google Scholar
Keizer RJ, Karlsson MO, Hooker A. Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose. CPT Pharmacomet Syst Pharmacol. 2013;2:50.
Baron KT. mrgsolve: Simulate from ODE-Based Models.
Dupont H, Massias L, Jung B, Ammenouche N, Montravers P. Pharmacokinetic study of anidulafungin in ICU patients with intra-abdominal candidiasis. J Antimicrob Chemother. 2017;72:1429–32.
Xie R, McFadyen L, Raber S, Swanson R, Tawadrous M, Leister-Tebbe H, et al. Population Analysis of Anidulafungin in infants to older adults with confirmed or suspected invasive candidiasis. Clin Pharmacol Ther. 2020;108:316–25.
Article CAS PubMed PubMed Central Google Scholar
Hall RG, Liu S, Putnam WC, Kallem R, Gumbo T, Pai MP. Optimizing anidulafungin exposure across a wide adult body size range. Antimicrob Agents Chemother. 2023;67:e00820–23.
Kapralos I, Mainas E, Apostolopoulou O, Siopi M, Neroutsos E, Apostolidi S, et al. Population pharmacokinetics of anidulafungin in ICU patients assessing inter- and intrasubject variability. Br J Clin Pharmacol. 2021;87:1024–32.
Article CAS PubMed Google Scholar
Liu P, Mould DR. Population Pharmacokinetic-Pharmacodynamic analysis of Voriconazole and Anidulafungin in Adult patients with invasive aspergillosis. Antimicrob Agents Chemother. 2014;58:4727–36.
Article PubMed PubMed Central Google Scholar
Wasmann RE, ter Heine R, van Dongen EP, Burger DM, Lempers VJ, Knibbe CA, et al. Pharmacokinetics of Anidulafungin in obese and normal-weight adults. Antimicrob Agents Chemother. 2018;62:e00063–18.
Article CAS PubMed PubMed Central Google Scholar
Brüggemann RJM, Van Der Velden WJFM, Knibbe CAJ, Colbers A, Hol S, Burger DM, et al. A rationale for reduced-frequency dosing of anidulafungin for antifungal prophylaxis in immunocompromised patients. J Antimicrob Chemother. 2015;70:1166–74.
Liu P, Ruhnke M, Meersseman W, Paiva JA, Kantecki M, Damle B. Pharmacokinetics of Anidulafungin in critically ill patients with Candidemia/Invasive candidiasis. Antimicrob Agents Chemother. 2013;57:1672–6.
Article CAS PubMed PubMed Central Google Scholar
Malbrain MLNG, Marik PE, Witters I, Cordemans C, Kirkpatrick AW, Roberts DJ, et al. Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice. Anestezjol Intensywna Ter. 2014;46:361–80.
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in Acute Lung Injury. N Engl J Med. 2006;354(24):2564–75.
Ruhnke M, Paiva JA, Meersseman W, Pachl J, Grigoras I, Sganga G, et al. Anidulafungin for the treatment of candidaemia/invasive candidiasis in selected critically ill patients. Clin Microbiol Infect. 2012;18:680–7.
Article CAS PubMed PubMed Central Google Scholar
Kullberg BJ, Vasquez J, Mootsikapun P, Nucci M, Paiva J-A, Garbino J, et al. Efficacy of anidulafungin in 539 patients with invasive candidiasis: a patient-level pooled analysis of six clinical trials. J Antimicrob Chemother. 2017;72:2368–77.
Article CAS PubMed PubMed Central Google Scholar
Dimopoulos G, Paiva J-A, Meersseman W, Pachl J, Grigoras I, Sganga G, et al. Efficacy and safety of anidulafungin in elderly, critically ill patients with invasive Candida infections: a post hoc analysis. Int J Antimicrob Agents. 2012;40:521–6.
Article CAS PubMed Google Scholar
Kim HY, Baldelli S, Märtson A-G, Stocker S, Alffenaar J-W, Cattaneo D, et al. Therapeutic drug monitoring of the Echinocandin Antifungal agents: is there a role in clinical practice? A position Statement of the Anti-infective Drugs Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Ther Drug Monit. 2022;44:198–214.
Comments (0)