Cilloniz C, Martin-Loeches I, Garcia-Vidal C, San Jose A, Torres A. Microbial etiology of pneumonia: epidemiology, diagnosis and resistance patterns. Int J Mol Sci. 2016. https://doi.org/10.3390/ijms17122120.

Article  PubMed  PubMed Central  Google Scholar 

Kutz A, Florin J, Hausfater P, et al. Predictors for Delayed Emergency Department Care in Medical patients with Acute infections – an international prospective observational study. PLoS ONE. 2016. https://doi.org/10.1371/journal.pone.0155363.

Article  PubMed  PubMed Central  Google Scholar 

Emanuel EJ, Persad G, Upshur R, et al. Fair allocation of scarce medical resources in the time of Covid-19. N Engl J Med. 2020. https://doi.org/10.1056/NEJMsb2005114.

Article  PubMed  Google Scholar 

Dyar OJ, Huttner B, Schouten J, Pulcini C. What is antimicrobial stewardship? Clin Microbiol Infect. 2017. https://doi.org/10.1016/j.cmi.2017.08.026.

Article  PubMed  Google Scholar 

Pulia MS, O’Brien TP, Hou PC, Schuman A, Sambursky R. Multimodal approach to COVID-19 diagnosis: a rapid review of the evidence for point-of-care diagnostic testing and imaging. Diagnostics. 2020;10(6):409.

Google Scholar 

Massaro KS, Costa SF, Leone C, et al. Procalcitonin (PCT) and C-reactive protein (CRP) as severe systemic infection markers in febrile neutropenic adults. BMC Infect Dis. 2007. https://doi.org/10.1186/1471-2334-7-137.

Article  PubMed  PubMed Central  Google Scholar 

Bourgoin P, Biéchelé G, Ait Belkacem I, Morange PE, Malergue F. Role of the interferons in CD64 and CD169 expressions in whole blood: relevance in the balance between viral- or bacterial-oriented immune responses. Immun Inflamm Dis. 2020;8(1):106–23. https://doi.org/10.1002/iid3.289.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourgoin P, Soliveres T, Barbaresi A, et al. CD169 and CD64 could help differentiate bacterial from COVID-19 or other viral infections in the Emergency Department. Cytometry A. 2021. https://doi.org/10.1002/cyto.a.24314.

Article  PubMed  PubMed Central  Google Scholar 

van de Ven NLM, Bongers SH, Spijkerman R, Koenderman L, Leenen LPH, Hietbrink F. COVPACH study group. Point-of-care neutrophil NCD64 as a rule in diagnostic test for bacterial infections in the emergency department. BMC Emerg Med; https://doi.org/10.1186/s12873-023-00800-2.

Venturini S, Orso D, Cugini F, Crapis M, Fossati S, Callegari A, Pellis T, Tonizzo M, Grembiale A, Rosso A, Tamburrini M, D’Andrea N, Vetrugno L, Bove T. Classification and analysis of outcome predictors in non-critically ill COVID-19 patients. Intern Med J. 2021;51(4):506–14. https://doi.org/10.1111/imj.15140.

Article  CAS  PubMed  PubMed Central  Google Scholar 

R Core Team. (2020) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.r-project.org/

Hoffmann J, Rheude A, Neubauer A, Brendel C, Thrun MC. Development of an explainable AI system using routine clinical parameters for rapid differentiation of inflammatory conditions. Front Immunol. 2024. https://doi.org/10.3389/fimmu.2024.1364954.

Article  PubMed  PubMed Central  Google Scholar 

Venturini S, Reffo I, Avolio M et al. Role of CD64 ratio determination in pneumococcal versus legionella community-acquired pneumonia. Open J Clin Med Case Rep. 2024;10(12):2235. https://jclinmedcasereports.com/articles/OJCMCR-2235.pdf

Kapasi AJ, Dittrich S, González IJ, Rodwell TC. Host biomarkers for distinguishing bacterial from non-bacterial causes of Acute Febrile illness: a Comprehensive Review. PLoS ONE. 2016. https://doi.org/10.1371/journal.pone.0160278.

Article  PubMed  PubMed Central  Google Scholar 

Cong S, Ma T, Di X, Tian C, Zhao M, Wang K. Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis. BMC Infect Dis. 2021. https://doi.org/10.1186/s12879-021-06064-0.

Article  PubMed  PubMed Central  Google Scholar 

Ozger HS, Senol E. Use of infection biomarkers in the emergency department. Turk J Emerg Med. 2022. https://doi.org/10.4103/2452-2473.357347.

Article  PubMed  PubMed Central  Google Scholar 

Patnaik R, Azim A, Agarwal V. Neutrophil CD64 a diagnostic and prognostic marker of Sepsis in adult critically ill patients: a brief review. Indian J Crit Care Med. 2020;24(12):1242–50. https://doi.org/10.5005/jp-journals-10071-23558.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Venturini S, Orso D, Cugini F, Del Fabro G, Callegari A, Reffo I, Villalta D, De Santi L, Pontoni E, Giordani D, Doretto P, Pratesi C, Tonizzo M, Colussi GL, Crapis M. Role of MR-proADM and monocyte CD169 in predicting in-hospital and 60-day mortality in COVID-19 patients. Clin Pathol. 2024. https://doi.org/10.1177/2632010X241304958.

Article  PubMed  PubMed Central  Google Scholar 

Hoeboer SH, van der Geest PJ, Nieboer D, Groeneveld AB. The diagnostic accuracy of procalcitonin for bacteraemia: a systematic review and meta-analysis. Clin Microbiol Infect. 2015. https://doi.org/10.1016/j.cmi.2014.12.026.

Article  PubMed  Google Scholar 

Kim WK, McGary CM, Holder GE, et al. Increased expression of MCD169 on blood monocytes and its regulation by Virus and CD8 T cells in Macaque models of HIV infection and AIDS. AIDS Res Hum Retroviruses. 2015. https://doi.org/10.1089/AID.2015.0003.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Xia Y, Qiu C. Functions of CD169 positive macrophages in human diseases (review). Biomedical Rep. 2021. https://doi.org/10.3892/br.2020.1402.

Article  Google Scholar 

Reynoso GV, Gordon DN, Kalia A, et al. Zika virus spreads through infection of lymph node-resident macrophages. Cell Rep. 2023. https://doi.org/10.1016/j.celrep.2023.112126.

Article  PubMed  PubMed Central  Google Scholar 

Jukema BN, de Hond TAP, Kroon M, Maranus AE, Koenderman L, Kaasjager KAH. Point-of-care neutrophil and monocyte surface markers differentiate bacterial from viral infections at the emergency department within 30 min. J Leukoc Biol. 2024. https://doi.org/10.1093/jleuko/qiad163.

Article  PubMed  Google Scholar 

Pratesi C, De Rosa R, Pivetta E, et al. Validation of monocyte CD169 expression as a valuable rapid diagnostic marker of SARS-CoV-2 and other acute viral infections. Am J Clin Pathol. 2024. https://doi.org/10.1093/ajcp/aqae127.

Article  PubMed  Google Scholar 

Inglis R, Ayebale E, Schultz MJ. Optimizing respiratory management in resource-limited settings. Curr Opin Crit Care. 2019. https://doi.org/10.1097/MCC.0000000000000568.

Article  PubMed  Google Scholar 

Chi-Chung Cheng V, Fuk-Woo Chan J, FN Hung I, Yuen KY. Viral infections, an overview with a Focus on Prevention of Transmission. Ref Module Biomedical Sci. 2016. https://doi.org/10.1016/B978-0-12-803678-5.00514-2.

Article  Google Scholar 

Le Saux N, Canadian Paediatric Society, Infectious Diseases and Immunization Committee. Antimicrobial stewardship in daily practice: managing an important resource. Can J Infect Dis Med Microbiol. 2014;25(5):241–5.

Article  PubMed  PubMed Central  Google Scholar 

Sartini M, Carbone A, Demartini A, et al. Overcrowding in Emergency Department: causes, consequences, and Solutions-A narrative review. Healthc (Basel). 2022. https://doi.org/10.3390/healthcare10091625.

Article  Google Scholar 

Raavi L, Isha S, Jonna S, et al. Association of antibiotics with the outcomes in COVID-19 pneumonia patients with elevated PCT levels. Respir Med. 2024. https://doi.org/10.1016/j.rmed.2024.107697.

Article  PubMed  Google Scholar 

Pickens CI, Gao CA, Bodner J, et al. NU SCRIPT Study investigators. An adjudication protocol for severe pneumonia. Open Forum Infect Dis. 2023. https://doi.org/10.1093/ofid/ofad336.

Article  PubMed  PubMed Central  Google Scholar 

Shiley KT, Lautenbach E, Lee I. The use of antimicrobial agents after diagnosis of viral respiratory tract infections in hospitalized adults: antibiotics or anxiolytics? Infect Control Hosp Epidemiol. 2010. https://doi.org/10.1086/656596.

Article  PubMed  PubMed Central  Google Scholar