UNAIDS. Global HIV and AIDS statistics—fact sheet 2023 2 November 2023.

Yarchoan R, Uldrick TS. HIV-associated cancers and related diseases. N Engl J Med. 2018;378(22):2145.

PubMed  Google Scholar 

Phillips L, Opie J. The utility of bone marrow sampling in the diagnosis and staging of lymphoma in South Africa. Int J Lab Hematol. 2018;40(3):276–83.

Article  CAS  PubMed  Google Scholar 

Wiggill T, Mayne E, Perner Y, Vaughan J. Changing patterns of lymphoma in the antiretroviral therapy era in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2021;88(3):252–60.

Article  CAS  PubMed  Google Scholar 

Swart L, Novitzky N, Mohamed Z, Opie J. Hodgkin lymphoma at Groote Schuur Hospital, South Africa: the effect of HIV and bone marrow infiltration. Ann Hematol. 2019;98(2):381–9.

Article  CAS  PubMed  Google Scholar 

Moahi K, Ralefala T, Nkele I, Triedman S, Sohani A, Musimar Z, et al. HIV and Hodgkin lymphoma survival: a prospective study in Botswana. JCO Glob Oncol. 2022;8:e2100163.

Article  PubMed  PubMed Central  Google Scholar 

Antel K, Chetty D, Oosthuizen J, Mohamed Z, Van der Vyver L, Verburgh E. CD68-positive tumour associated macrophages, PD-L1 expression, and EBV latent infection in a high HIV-prevalent South African cohort of Hodgkin lymphoma patients. Pathology. 2021;53(5):628–34.

Article  CAS  PubMed  Google Scholar 

Carbone A, Volpi CC, Gualeni AV, Gloghini A. Epstein-Barr virus associated lymphomas in people with HIV. Curr Opin HIV AIDS. 2017;12(1):39–46.

Article  CAS  PubMed  Google Scholar 

Thorley-Lawson DA, Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Engl J Med. 2004;350(13):1328–37.

Article  CAS  PubMed  Google Scholar 

Swerdlow SH CE, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J. WHO classification of tumours of haematopoietic and lymphoid tissues: international agency of research on cancer. 2017.

Kanakry JA, Li H, Gellert LL, Lemas MV, Hsieh WS, Hong F, et al. Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial. Blood. 2013;121(18):3547–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Welch JJG, Schwartz CL, Higman M, Chen L, Buxton A, Kanakry JA, et al. Epstein-Barr virus DNA in serum as an early prognostic marker in children and adolescents with Hodgkin lymphoma. Blood Adv. 2017;1(11):681–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanakry JA, Hegde AM, Durand CM, Massie AB, Greer AE, Ambinder RF, et al. The clinical significance of EBV DNA in the plasma and peripheral blood mononuclear cells of patients with or without EBV diseases. Blood. 2016;127(16):2007–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang WS, Vergilio JA, Salhia B, Huang HJ, Oki Y, Garrido-Laguna I, et al. Comprehensive genomic profiling of Hodgkin lymphoma reveals recurrently mutated genes and increased mutation burden. Oncologist. 2019;24(2):219–28.

Article  CAS  PubMed  Google Scholar 

Kimura H, Kwong YL. EBV viral loads in diagnosis, monitoring, and response assessment. Front Oncol. 2019;9:62.

Article  PubMed  PubMed Central  Google Scholar 

Smatti MK, Yassine HM, AbuOdeh R, AlMarawani A, Taleb SA, Althani AA, et al. Prevalence and molecular profiling of Epstein Barr virus (EBV) among healthy blood donors from different nationalities in Qatar. PLoS ONE. 2017;12(12):e0189033.

Article  PubMed  PubMed Central  Google Scholar 

Stevens SJ, Blank BS, Smits PH, Meenhorst PL, Middeldorp JM. High Epstein-Barr virus (EBV) DNA loads in HIV-infected patients: correlation with antiretroviral therapy and quantitative EBV serology. AIDS. 2002;16(7):993–1001.

Article  CAS  PubMed  Google Scholar 

Alberti A, Stocker G, Lordick F, Hacker UT, Kobitzsch B, Haffner I, et al. Plasma EBV DNA as a prognostic factor in EBV associated gastric cancer: a multicenter, prospective study (EBV PRESAGE study). Front Oncol. 2023;13:1276138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Zhou J, Cheng F, Chen D, Guan F, Zhang E, et al. Role of plasma EBV-DNA load and EBER status on newly diagnosed peripheral T-cell lymphoma. J Cancer Res Clin Oncol. 2024;150(4):181.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meyer RM. EBV DNA: a Hodgkin lymphoma biomarker? Blood. 2013;121(18):3541–2.

Article  CAS  PubMed  Google Scholar 

Ul-Haq I, Dalla Pria A, Suardi E, Pinato DJ, Froeling F, Forni J, et al. Blood Epstein-Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma. Med Oncol. 2018;35(4):53.

Article  PubMed  PubMed Central  Google Scholar 

Lupo J, Germi R, Lancar R, Algarte-Genin M, Hendel-Chavez H, Taoufik Y, et al. Epstein-Barr virus biomarkers have no prognostic value in HIV-related Hodgkin lymphoma in the modern combined antiretroviral therapy era. AIDS. 2019;33(6):993–1000.

Article  CAS  PubMed  Google Scholar 

Yu S, Yang Q, Wu J, Zhu M, Ai J, Zhang H, et al. Clinical application of Epstein-Barr virus DNA loads in Epstein-Barr virus-associated diseases: a cohort study. J Infect. 2021;82(1):105–11.

Article  CAS  PubMed  Google Scholar 

Shen Z, Hu L, Yao M, He C, Liu Q, Wang F, et al. Disparity analysis and prognostic value of pretreatment whole blood Epstein-Barr virus DNA load and Epstein-Barr encoding region status in lymphomas: a retrospective multicenter study in Huaihai lymphoma working group. Int J Cancer. 2022;150(2):327–34.

Article  CAS  PubMed  Google Scholar 

Tomoka T, Montgomery ND, Powers E, Dhungel BM, Morgan EA, Mulenga M, et al. Lymphoma and pathology in Sub-Saharan Africa: current approaches and future directions. Clin Lab Med. 2018;38(1):91–100.

Article  PubMed  Google Scholar 

Fryer JF, Heath AB, Wilkinson DE, Minor PD. A collaborative study to establish the 1st WHO international standard for Epstein-Barr virus for nucleic acid amplification techniques. Biologicals. 2016;44(5):423–33.

Article  CAS  PubMed  Google Scholar 

Zaucha JM, Chauvie S, Zaucha R, Biggii A, Gallamini A. The role of PET/CT in the modern treatment of Hodgkin lymphoma. Cancer Treat Rev. 2019;77:44–56.

Article  PubMed  Google Scholar 

Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27):3059–68.

Article  PubMed  PubMed Central  Google Scholar 

Hu J, Zhang X, Tao H, Jia Y. The prognostic value of Epstein-Barr virus infection in Hodgkin lymphoma: a systematic review and meta-analysis. Front Oncol. 2022;12:1034398.

Article  PubMed  PubMed Central  Google Scholar 

Qin JQ, Yin H, Wu JZ, Chen RZ, Xia Y, Wang L, et al. Pretreatment whole blood Epstein-Barr virus DNA predicts prognosis in Hodgkin lymphoma. Leuk Res. 2021;107:106607.

Article  CAS  PubMed  Google Scholar 

Brice P, de Kerviler E, Friedberg JW. Classical Hodgkin lymphoma. Lancet. 2021;398(10310):1518–27.

Article  PubMed  Google Scholar 

Driessen J, Visser O, Zijlstra JM, Lugtenburg PJ, Plattel WJ, Kersten MJ, et al. Primary therapy and relative survival in classical Hodgkin lymphoma: a nationwide population-based study in the Netherlands, 1989–2017. Leukemia. 2021;35(2):494–505.

Article  CAS  PubMed