Autophagy-based therapy for hepatocellular carcinoma: from standard treatments to combination therapy, oncolytic virotherapy, and targeted nanomedicines

Raudenska M, Balvan J, Masarik M. Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers. Mol Cancer. 2021;20(1):1–27.

Article  Google Scholar 

Fan C, Zhang S, Gong Z, Li X, Xiang B, Deng H, et al. Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy. Sci China Life Sci. 2021;64:534–47.

Article  PubMed  Google Scholar 

Marino M, Fais S, Djavaheri-Mergny M, Villa A, Meschini S, Lozupone F, et al. Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells. Cell Death Disease. 2010;1(10):e87-e.

Article  Google Scholar 

Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, et al. ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 2007;14(2):230–9.

Article  CAS  PubMed  Google Scholar 

Zhang X, Jing Y, Qin C, Liu C, Yang D, Gao F, et al. Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury. J Cell Mol Med. 2020;24(21):12765–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Catanese A, Olde Heuvel F, Mulaw M, Demestre M, Higelin J, Barbi G, et al. Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation. Autophagy. 2019;15(10):1719–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004;6(4):463–77.

Article  CAS  PubMed  Google Scholar 

Yang Z, Klionsky DJ. An overview of the molecular mechanism of autophagy. Autophagy Infect Immunity. 2009:1–32.

Ezaki J, Matsumoto N, Takeda-Ezaki M, Komatsu M, Takahashi K, Hiraoka Y, et al. Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy. 2011;7(7):727–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim J, Kundu M, Viollet B, Guan K-L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011;13(2):132–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011;147(4):728–41.

Article  CAS  PubMed  Google Scholar 

Behrends C, Sowa ME, Gygi SP, Harper JW. Network organization of the human autophagy system. Nature. 2010;466(7302):68–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogata M, Hino S-I, Saito A, Morikawa K, Kondo S, Kanemoto S, et al. Autophagy is activated for cell survival after endoplasmic ReticulumStress. Mol Cell Biol. 2006;26(24):9220–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368(7):651–62.

Article  CAS  PubMed  Google Scholar 

Schneider JL, Cuervo AM. Liver autophagy: much more than just taking out the trash. Nat Rev Gastroenterol Hepatol. 2014;11(3):187–200.

Article  PubMed  Google Scholar 

Ashrafizadeh M, Paskeh MDA, Mirzaei S, Gholami MH, Zarrabi A, Hashemi F, et al. Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response. J Exp Clin Cancer Res. 2022;41(1):1–37.

Article  Google Scholar 

Xu F, Yan W, Cheng Y. Pou4f3 gene mutation promotes autophagy and apoptosis of cochlear hair cells in cisplatin-induced deafness mice. Arch Biochem Biophys. 2020;680: 108224.

Article  CAS  PubMed  Google Scholar 

Weisheit S, Wegner CS, Ailte I, Radulovic M, Weyergang A, Selbo PK, et al. Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy. Biochem Pharmacol. 2021;194: 114837.

Article  CAS  PubMed  Google Scholar 

Tunissiolli NM, Castanhole-Nunes MMU, Biselli-Chicote PM, Pavarino EC, da Silva RF, da Silva RC, et al. Hepatocellular carcinoma: a comprehensive review of biomarkers, clinical aspects, and therapy. Asian Pac J Cancer Prevent APJCP. 2017;18(4):863–72.

Google Scholar 

Liu L, Liao J-Z, He X-X, Li P-Y. The role of autophagy in hepatocellular carcinoma: friend or foe. Oncotarget. 2017;8(34):57707.

Article  PubMed  PubMed Central  Google Scholar 

Sheng J, Qin H, Zhang K, Li B, Zhang X. Targeting autophagy in chemotherapy-resistant of hepatocellular carcinoma. Am J Cancer Res. 2018;8(3):354.

CAS  PubMed  PubMed Central  Google Scholar 

Huang F, Wang B-R, Wang Y-G. Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma. World J Gastroenterol. 2018;24(41):4643.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang H, Xiong Z, Li R, Hu K, Cao M, Yang J, et al. BDH2 is downregulated in hepatocellular carcinoma and acts as a tumor suppressor regulating cell apoptosis and autophagy. J Cancer. 2019;10(16):3735.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deust A, Chobert M-N, Demontant V, Gricourt G, Denaës T, Thiolat A, et al. Macrophage autophagy protects against hepatocellular carcinogenesis in mice. Sci Rep. 2021;11(1):18809.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sorice M. Crosstalk of autophagy and apoptosis. MDPI; 2022. p. 1479.

Ding Z-B, Shi Y-H, Zhou J, Qiu S-J, Xu Y, Dai Z, et al. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Can Res. 2008;68(22):9167–75.

Article  CAS  Google Scholar 

Janji B, Berchem G, Chouaib S. Targeting autophagy in the tumor microenvironment: new challenges and opportunities for regulating tumor immunity. Front Immunol. 2018;9:887.

Article  PubMed  PubMed Central  Google Scholar 

White E, Karp C, Strohecker AM, Guo Y, Mathew R. Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol. 2010;22(2):212–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 2007;21(11):1367–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katsuragi Y, Ichimura Y, Komatsu M. Regulation of the Keap1–Nrf2 pathway by p62/SQSTM1. Curr Opin Toxicol. 2016;1:54–61.

Article  Google Scholar 

Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, et al. p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell. 2016;29(6):935–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci. 2003;100(25):15077–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Investig. 2003;112(12):1809–20.

Article  CAS  PubMed 

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