Granzyme mRNA-miRNA interaction and its implication to functional impact

Bouwman AC, van Daalen KR, Crnko S, Ten Broeke T, Bovenschen N (2021) Intracellular and extracellular roles of granzyme K. Front Immunol 12:677707. https://doi.org/10.3389/fimmu.2021.677707

Article  PubMed  CAS  PubMed Central  Google Scholar 

Calin GA, Sevignani C, Dumitru CD et al (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101:2999–3004. https://doi.org/10.1073/pnas.0307323101

Article  PubMed  CAS  PubMed Central  Google Scholar 

Chakrabortty A, Patton DJ, Smith BF, Agarwal P (2023) miRNAs: potential as biomarkers and therapeutic targets for cancer. Genes (Basel) 14(7):1375. https://doi.org/10.3390/genes14071375

Article  PubMed  CAS  Google Scholar 

Chehelgerdi M, Chehelgerdi M (2023) The use of RNA-based treatments in the field of cancer immunotherapy. Mol Cancer 22(1):106. https://doi.org/10.1186/s12943-023-01807-w

Article  PubMed  CAS  PubMed Central  Google Scholar 

Chowdhury D, Lieberman J (2008) Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol 26:389–420. https://doi.org/10.1146/annurev.immunol.26.021607.090404

Article  PubMed  CAS  PubMed Central  Google Scholar 

Cichocki F, Felices M, McCullar V, Presnell SR, Al-Attar A, Lutz CT, Miller JS (2011) Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol 187(12):6171–6175. https://doi.org/10.4049/jimmunol.1100835

Article  PubMed  CAS  Google Scholar 

Diaz-Cañestro C, Reiner MF, Bonetti NR et al (2019) AP-1 (Activated Protein-1) transcription factor JunD regulates ischemia/reperfusion brain damage via IL-1β (Interleukin-1β). Stroke 50(2):469–477. https://doi.org/10.1161/STROKEAHA.118.023739

Article  PubMed  CAS  Google Scholar 

Gao F, He S, Jin A (2021) MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma. Genes Dis 8(5):590–602. https://doi.org/10.1016/j.gendis.2020.08.006

Article  PubMed  CAS  Google Scholar 

Grossman WJ, Revell PA, Lu ZH, Johnson H, Bredemeyer AJ, Ley TJ (2003) The orphan granzymes of humans and mice. Curr Opin Immunol 15(5):544–552. https://doi.org/10.1016/s0952-7915(03)00099-2

Article  PubMed  CAS  Google Scholar 

Hay ZLZ, Slansky JE (2022) Granzymes: the molecular executors of immune-mediated cytotoxicity. Int J Mol Sci 23(3):1833. https://doi.org/10.3390/ijms23031833

Article  PubMed  CAS  PubMed Central  Google Scholar 

Inamura K, Ishikawa Y (2016) MicroRNA in lung cancer: novel biomarkers and potential tools for treatment. J Clin Med 5(3):36. https://doi.org/10.3390/jcm5030036

Article  PubMed  CAS  PubMed Central  Google Scholar 

Jin Y, Dai Y, Qiao O, Hu P, Han J (2024) miR-1972 inhibits hepatocellular carcinoma proliferation by targeting GZMH-mediated DNA replication in the cell cycle. J Pharm Pharmacy. https://doi.org/10.1093/jpp/rgae037

Article  Google Scholar 

Kaiserman D, Bird P (2010) Control of granzymes by serpins. Cell Death Differ 17:586–595. https://doi.org/10.1038/cdd.2009.169

Article  PubMed  CAS  Google Scholar 

Kim TD, Lee SU, Yun S et al (2011) Human microRNA-27a targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity. Blood 118(20):5476–5486. https://doi.org/10.1182/blood-2011-04-347526

Article  PubMed  CAS  PubMed Central  Google Scholar 

Kim WR, Park EG, Lee HE et al (2022) Hsa-miR-422a Originated from short interspersed nuclear element increases ARID5B expression by collaborating with NF-E2. Mol Cells 45(7):465–478. https://doi.org/10.14348/molcells.2022.2158

Article  PubMed  CAS  PubMed Central  Google Scholar 

Lee HE, Park SJ, Huh JW et al (2021) The enhancer activity of long interspersed nuclear element derived microRNA 625 induced by NF-κB. Sci Rep 11:3139. https://doi.org/10.1038/s41598-021-82735-x

Article  PubMed  CAS  PubMed Central  Google Scholar 

Leong JW, Sullivan RP, Fehniger TA (2014) microRNA management of NK-cell developmental and functional programs. Eur J Immunol 44(10):2862–2868. https://doi.org/10.1002/eji.201444798

Article  PubMed  CAS  PubMed Central  Google Scholar 

Liu S, Chen L, Zeng Y, Si L, Guo X, Zhou J, Fang D, Zeng G, Jiang L (2016) Suppressed expression of miR-378 targeting gzmb in NK cells is required to control dengue virus infection. Cell Mol Immunol 13(5):700–708. https://doi.org/10.1038/cmi.2015.52

Article  PubMed  CAS  Google Scholar 

Nalbant E, Akkaya-Ulum YZ (2024) Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases. Clin Exp Med 24:142. https://doi.org/10.1007/s10238-024-01334-y

Article  CAS  PubMed Central  Google Scholar 

O’Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402. https://doi.org/10.3389/fendo.2018.00402

Article  PubMed  CAS  Google Scholar 

Oliveto S, Mancino M, Manfrini N, Biffo S (2017) Role of microRNAs in translation regulation and cancer. World J Biol Chem. 8(1):45–56. https://doi.org/10.4331/wjbc.v8.i1.45

Article  PubMed  PubMed Central  Google Scholar 

Peng L, Sferruzza G, Yang L et al (2024) CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors. Cell Mol Immunol. https://doi.org/10.1038/s41423-024-01207-0

Article  PubMed  PubMed Central  Google Scholar 

Qi Z, Li S, Su Y, Zhang J, Kang Y, Huang Y, Jin F, Xing Q (2019) Role of microRNA-145 in protection against myocardial ischemia/reperfusion injury in mice by regulating expression of GZMK with the treatment of sevoflurane. J Cell Physiol 234(9):16526–16539. https://doi.org/10.1002/jcp.28323

Article  PubMed  CAS  Google Scholar 

Ruiz EJ, Lan L, Diefenbacher ME et al (2021) JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. JCI Insight 6(13):e124985. https://doi.org/10.1172/jci.insight.124985

Article  PubMed  PubMed Central  Google Scholar 

Ruppert SM, Chehtane M, Zhang G et al (2012) JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction. PLoS ONE 7(2):e32262. https://doi.org/10.1371/journal.pone.0032262

Article  PubMed  CAS  PubMed Central  Google Scholar 

Sanchez-Martínez D, Krzywinska E, Rathore MG et al (2014) All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity. Int J Biochem Cell Biol 49:42–52. https://doi.org/10.1016/j.biocel.2014.01.003

Article  PubMed  CAS  Google Scholar 

Scott JI, Mendive-Tapia L, Gordon D et al (2022) A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies. Nat Commun 13:2366. https://doi.org/10.1038/s41467-022-29691-w

Article  PubMed  CAS  PubMed Central 

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