We thank Sikandari et al for their comments regarding the long-term prognosis of patients with chest pain who present in the emergency department with low or undetectable high-sensitivity cardiac troponin T (hs-cTnT) concentrations.1 Two issues are raised in the comment which we would like to respond to.

The authors of the comment propose that the inclusion of patients with elevated hs-cTnT concentrations would better help clinicians categorise risk assessment, since the risk of adverse cardiovascular outcomes is higher in this group compared with patients with low …