3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells

Medzhitov R (2010) Inflammation 2010: new adventures of an old flame. Cell 140:771–776

Article  PubMed  CAS  Google Scholar 

Freire MO, Van Dyke TE (2013) Natural resolution of inflammation. Periodontol 2000(63):149–164

Article  Google Scholar 

Tabas I, Glass CK (2013) Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 339:166–172

Article  PubMed  PubMed Central  CAS  Google Scholar 

Park BS, Lee JO (2013) Recognition of lipopolysaccharide pattern by TLR4 complexes. Exp Mol Med 45:e66

Article  PubMed  PubMed Central  Google Scholar 

Zhang Q, Wang L, Wang S, Cheng H, Xu L, Pei G, Wang Y, Fu C, Jiang Y, He C, Wei Q (2022) Signaling pathways and targeted therapy for myocardial infarction. Signal Transduct Target Ther 7:78–116

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yuan Q, Tang B, Zhang C (2022) Signaling pathways of chronic kidney diseases, implications for therapeutics. Signal Transduct Target Ther 7:182–209

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen Y, Fang ZM, Yi X, Wei X, Jiang DS (2023) The interaction between ferroptosis and inflammatory signaling pathways. Cell Death Dis 14:205–218

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hayden MS, Ghosh S (2008) Shared principles in NF-κB signaling. Cell 132:344–362

Article  PubMed  CAS  Google Scholar 

Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499–511

Article  PubMed  CAS  Google Scholar 

Zorov DB, Juhaszova M, Sollott SJ (2014) Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 94:909–950

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou XD, Chen CX, Zheng XK, Gong LM, Zeng KW, Wang W, Tu PF (2021) Dibenzocyclooctadiene lignans from Artemisia sieversiana and their anti-inflammatory activities. J Nat Med 75:1014–1020

Article  PubMed  CAS  Google Scholar 

Suleimenov EM, Smagulova FM, Seidakhmetova RB, Aksartov RM, Raldugin VA, Adekenov SM (2007) 4-Epiashantin from Artemisia sieversiana. Chem Nat Compd 43:232–233

Article  CAS  Google Scholar 

Liu SJ, Liao ZX, Liu C, Ji LJ, Sun H (2014) Two new sesquiterpenes from Artemisia sieversiana. Fitoterapia 97:43–49

Article  PubMed  CAS  Google Scholar 

Bohlmann F, Ang W, Trinks C, Jakupovic J, Huneck S (1985) Dimeric guaianolides from Artemisia sieversiana. Phytochemistry 24:1009–1015

Article  CAS  Google Scholar 

Dong W, Huang XY, Li TZ, Weng YM, Geng CA, Chen JJ (2024) Artemsieverolactones A—H, eight guaiane-type sesquiterpenoid trimers from Artemisia sieversiana. Chin J Chem 42:1084–1092

Article  CAS  Google Scholar 

Liu SJ, Liao ZX, Tang ZS, Cui CL, Liu HB, Liang YN, Zhang Y, Shi HX, Liu YR (2017) Phytochemicals and biological activities of Artemisia sieversiana. Phytochem Rev 16:441–460

Article  CAS  Google Scholar 

Nuermaimaiti M, Turak A, Yang Q, Tang B, Zang Y, Li J, Aisa HA (2021) Sesquiterpenes from Artemisia Sieversiana and their anti-inflammatory activities. Fitoterapia 154:104996

Article  PubMed  CAS  Google Scholar 

Zhou XD, Chai XY, Zeng KW, Zhao MB, Jiang Y, Tu PF (2015) Artesin A, a new cage-shaped dimeric guaianolide from Artemisia sieversiana. Tetrahedron Lett 56:1141–1143

Article  CAS  Google Scholar 

Cao Y, Feng YH, Gao LW, Li XY, Jin QX, Wang YY, Xu YY, Jin F, Lu SL, Wei MJ (2019) Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo. Int Immunopharmacol 70:110–116

Article  PubMed  CAS  Google Scholar 

Barrero AF, Quílez del Moral JF, Lara A, Herrador MM (2005) Antimicrobial activity of Sesquiterpenes from the essential oil of Juniperus thurifera Wood. Planta Med 71:67–71

Article  PubMed  CAS  Google Scholar 

Cheng XR, Zeng Q, Ren J, Qin JJ, Zhang SD, Shen YH, Zhu JX, Zhang F, Chang RJ, Zhu Y, Zhang WD, Jin HZ (2011) Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents. Eur J Med Chem 46:5408–5415

Article  PubMed  CAS  Google Scholar 

Liu L, Liu D, Xiang C, Dai W, Li B, Zhang M (2020) Sesquiterpene lactones from Artemisia austroyunnanensis suppresses ROS production and reduces cytokines, iNOS and COX-2 levels via NF-KB pathway in vitro. Nat Prod Res 34:1563–1566

Article  PubMed  CAS  Google Scholar 

Long J, Zhang SF, Wang PP, Zhang XM, Yang ZJ, Zhang Q, Chen Y (2014) Total syntheses of parthenolide and its analogues with macrocyclic stereocontrol. J Med Chem 57:7098–7112

Article  PubMed  CAS  Google Scholar 

Bai M, Chen JJ, Xu W, Dong SH, Liu QB, Lin B, Huang XX, Yao GD, Song SJ (2020) Elephantopinolide A-P, germacrane-type sesquiterpene lactones from Elephantopus scaber induce apoptosis, autophagy and G2/M phase arrest in hepatocellular carcinoma cells. Eur J Med Chem 198:112362

Article  PubMed  CAS  Google Scholar 

Freund RRA, Gobrecht P, Fischer D, Arndt HD (2020) Advances in chemistry and bioactivity of parthenolide. Nat Prod Rep 37:541–565

Article  PubMed  CAS  Google Scholar 

Xu H, Chen J, Chen P, Li W, Shao J, Hong S, Wang Y, Chen L, Luo W, Liang G (2023) Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases. Acta Pharm Sin B 13:678–693

Article  PubMed  CAS  Google Scholar 

Tan RX, Lu H, Wolfender JL, Yu TT, Zheng WF, Yang L, Gafner S, Hostettmann K (1999) Mono- and sesquiterpenes and antifungal constituents from Artemisia species. Planta Med 65:64–67

Article  PubMed  CAS  Google Scholar 

Zhang X, Yang T, Jin X, Lin K, Dai X, Gao T, Huang G, Fan M, Ma L, Liu Z, Cao J (2022) Synthesis and biological evaluation of cytotoxic activity of novel podophyllotoxin derivatives incorporating piperazinyl-cinnamic amide moieties. Bioorg Chem 123:105761

Article  PubMed  CAS  Google Scholar 

Zhou M, Tang Y, Liao L, Liu M, Li Y (2021) Phillygenin inhibited LPS-induced RAW 264.7 cell inflammation by NF-κB pathway. Eur J Pharmacol 899:174043

Article  PubMed  CAS  Google Scholar 

Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131–138

Article  PubMed  CAS  Google Scholar 

Hao H, Cao L, Jiang C, Che Y, Zhang S, Takahashi S, Wang G, Gonzalez FJ (2017) Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis. Cell Metab 25:856–867

Article  PubMed  PubMed Central  CAS  Google Scholar 

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