Real-life effects of pharmacological osteoporosis treatments on bone mineral density by quantitative computed tomography

Deshpande N, Hadi MS, Lillard JC, Passias PG, Linzey JR, Saadeh YS, LaBagnara M, Park P (2023) Alternatives to DEXA for the assessment of bone density: a systematic review of the literature and future recommendations. J Neurosurg Spine 38:436–445. https://doi.org/10.3171/2022.11.SPINE22875

Article  PubMed  Google Scholar 

Li N, Li XM, Xu L, Sun WJ, Cheng XG, Tian W (2013) Comparison of QCT and DXA: osteoporosis detection rates in postmenopausal women. Int J Endocrinol. https://doi.org/10.1155/2013/895474

Article  PubMed  PubMed Central  Google Scholar 

Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ (2003) The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349:1207–1215. https://doi.org/10.1056/NEJMoa031975

Article  CAS  PubMed  Google Scholar 

Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB (2020) American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis— 2020 update executive summary. Endocr Pract 26:564–570. https://doi.org/10.4158/GL-2020-0524

Article  PubMed  Google Scholar 

Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM (2008) Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD official positions. J Clin Densitom 11:123–162. https://doi.org/10.1016/j.jocd.2007.12.010

Article  PubMed  Google Scholar 

Chen JS, Sambrook PN (2012) Antiresorptive therapies for osteoporosis: a clinical overview. Nat Rev Endocrinol 8:81–91. https://doi.org/10.1038/nrendo.2011.146

Article  CAS  Google Scholar 

McClung MR, Clark AL (2022) Osteoanabolic therapy for osteoporosis in women. Climacteric 25:60–66. https://doi.org/10.1080/13697137.2021.1953463

Article  CAS  PubMed  Google Scholar 

Foessl I, Dimai HP, Obermayer-Pietsch B (2023) Long-term and sequential treatment for osteoporosis. Nat Rev Endocrinol 19:520–533. https://doi.org/10.1038/s41574-023-00866-9

Article  PubMed  Google Scholar 

Siris E (2000) Alendronate in the treatment of osteoporosis: a review of the clinical trials. J Womens Health Gend Based Med 9:599–606. https://doi.org/10.1089/15246090050118125

Article  CAS  PubMed  Google Scholar 

Cummings SR, Martin JS, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361:756–765. https://doi.org/10.1056/NEJMoa0809493

Article  CAS  PubMed  Google Scholar 

Iba K, Takada J, Sonoda T, Yamashita T (2020) Effect of continuous long-term treatment for 10 years with bisphosphonate on Japanese osteoporosis patients. J Bone Miner Metab 38:240–247. https://doi.org/10.1007/s00774-019-01049-1

Article  CAS  PubMed  Google Scholar 

Papapoulos S, Lippuner K, Roux C, Lin CJF, Kendler DL et al (2015) The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study. Osteoporos Int 26:2773–2783. https://doi.org/10.1007/s00198-015-3234-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leder BZ, Tsai JN, Uihlein AV, Wallace PM, Lee H, Neer RM, Burnett-Bowie S-AM (2015) Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial. The Lancet 386:1147–1155. https://doi.org/10.1016/S0140-6736(15)61120-5

Article  CAS  Google Scholar 

Engelke K, Fuerst T, Dasic G, Davies RY, Genant HK (2010) Regional distribution of spine and hip QCT BMD responses after one year of once-monthly ibandronate in postmenopausal osteoporosis. Bone 46:1626–1632. https://doi.org/10.1016/j.bone.2010.03.003

Article  PubMed  Google Scholar 

Agarwal S, Shane E, Lang T, Shiau S, Kamanda-Kosseh M, Bucovsky M, Lappe JM, Stubby J, Recker RR, Hu Y, Wang Z, Edward Guo X, Cohen A (2022) Spine volumetric BMD and strength in premenopausal idiopathic osteoporosis: effect of teriparatide followed by denosumab. J Clin Endocrinol Metab 107:e2690–e2701. https://doi.org/10.1210/clinem/dgac232

Article  PubMed  PubMed Central  Google Scholar 

Genant HK, Libanati C, Engelke K, Zanchetta JR, Høiseth A, Yuen CK, Stonkus S, Bolognese MA, Franek E, Fuerst T, Radcliffe H-S, McClung MR (2013) Improvements in hip trabecular, subcortical, and cortical density and mass in postmenopausal women with osteoporosis treated with denosumab. Bone 56:482–488. https://doi.org/10.1016/j.bone.2013.07.011

Article  CAS  PubMed  Google Scholar 

Genant HK, Engelke K, Bolognese MA, Mautalen C, Brown JP, Recknor C, Goemaere S, Fuerst T, Yang Y, Grauer A, Libanati C (2017) Effects of romosozumab compared with teriparatide on bone density and mass at the spine and hip in postmenopausal women with low bone mass. J Bone Miner Res 32:181–187. https://doi.org/10.1002/jbmr.2932

Article  CAS  PubMed  Google Scholar 

Tsuchiya K, Ishikawa K, Kudo Y, Tani S, Nagai T, Toyone T, Inagaki K (2021) Analysis of the subsequent treatment of osteoporosis by transitioning from bisphosphonates to denosumab, using quantitative computed tomography: a prospective cohort study. Bone Rep 14:101090. https://doi.org/10.1016/j.bonr.2021.101090

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramchand SK, David NL, Lee H, Eastell R, Tsai JN, Leder BZ (2021) Efficacy of zoledronic acid in maintaining areal and volumetric bone density after combined denosumab and teriparatide administration: DATA-HD study extension. J Bone Miner Res 36:921–930. https://doi.org/10.1002/jbmr.4259

Article  CAS  PubMed  Google Scholar 

Kim S-J, Lee D-W (2023) A retrospective analysis of nonresponse to denosumab after hip fractures. Acta Orthop Belg 89:71–76. https://doi.org/10.52628/89.1.9808

Article  CAS  PubMed  Google Scholar 

Sebba AI, Lou BS, Kagan R, Thompson DE, Skalky CS, Chen E, de Papp AE (2004) Response to therapy with once-weekly alendronate 70 mg compared to once-weekly risedronate 35 mg in the treatment of postmenopausal osteoporosis. Curr Med Res Opin 20:2031–2041. https://doi.org/10.1185/030079904X16768

Article  CAS  PubMed  Google Scholar 

Konings V, Laurent MR, Janssens S, Dupont J, Gielen E, Dejaeger M (2023) Skeletal response to teriparatide in real-life setting: effects of age, baseline bone density and prior denosumab use. Acta Clin Belg 78:446–451. https://doi.org/10.1080/17843286.2023.2238375

Article  CAS  PubMed  Google Scholar 

Francis RM (2004) Non-response to osteoporosis treatment. Br Menopause Soc J 10:76–80. https://doi.org/10.1258/136218004774202409

Article  Google Scholar 

Kulkarni AG, Thonangi Y, Pathan S, Gunjotikar S, Goparaju P, Talwar I, Jaggi S, Shah S, Shah N, Kursija G (2022) Should Q-CT be the gold standard for detecting spinal osteoporosis? Spine (Phila Pa 1976) 47:E258–E264. https://doi.org/10.1097/BRS.0000000000004224

Article  PubMed  Google Scholar 

Verbeke G, Molenberghs G (2009) Linear Mixed Models for Longitudinal Data. Springer

Google Scholar 

R Core Team (2021) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/

Chen M, Gerges M, Raynor WY, Park PSU, Nguyen E, Chan DH, Gholamrezanezhad A (2023) State of the art imaging of osteoporosis. Semin Nucl Med. https://doi.org/10.1053/j.semnuclmed.2023.10.008

Article  PubMed  Google Scholar 

Cherney DD, Laymon MS, McNitt A, Yuly S (2002) A study on the influence of calcified intervertebral disk and aorta in determining bone mineral density. J Clin Densitom 5:193–198. https://doi.org/10.1385/JCD:5:2:193

Article  PubMed  Google Scholar 

Orwoll ES, Oviatt SK, Mann T (1990) The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men*. J Clin Endocrinol Metab 70:1202–1207. https://doi.org/10.1210/jcem-70-4-1202

Article  CAS  PubMed 

Comments (0)

No login
gif