Association of metabolically healthy obesity with risk of heart failure and left ventricular dysfunction among older adults

Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, et al. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. Circulation. 2022;145:e153–e639.

Article  PubMed  Google Scholar 

Blecker S, Paul M, Taksler G, Ogedegbe G, Katz S. Heart failure–associated hospitalizations in the United States. J Am Coll Cardiol. 2013;61:1259–67.

Article  PubMed  Google Scholar 

Tromp J, Paniagua SMA, Lau ES, Allen NB, Blaha MJ, Gansevoort RT, et al. Age dependent associations of risk factors with heart failure: pooled population based cohort study. Bmj. 2021;372:n461.

Article  PubMed  PubMed Central  Google Scholar 

Ryg J, Anru PL, Engberg H, Jorgensen MG, Masud T, Christensen K, et al. Association of Body Mass Index With All-Cause Mortality in Acutely Hospitalized Older Patients. J Am Med Dir Assoc. 2022;23:507–13.e1.

Article  PubMed  Google Scholar 

Fonseca G, von Haehling S. The fatter, the better in old age: the current understanding of a difficult relationship. Curr Opin Clin Nutr Metab Care. 2022;25:1–6.

Article  PubMed  Google Scholar 

Amankwaa I, Nelson K, Rook H, Hales C. Association between body mass index, multi-morbidity and activities of daily living among New Zealand nursing home older adults: a retrospective analysis of nationwide InterRAI data. BMC Geriatrics. 2022;22:62.

Article  PubMed  PubMed Central  Google Scholar 

Piché ME, Tchernof A, Després JP. Obesity Phenotypes, Diabetes, and Cardiovascular Diseases. Circ Res. 2020;126:1477–500.

Article  PubMed  Google Scholar 

Després JP. Body fat distribution and risk of cardiovascular disease: an update. Circulation. 2012;126:1301–13.

Article  PubMed  Google Scholar 

Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants. Lancet. 2014;383:970–83.

Article  PubMed  Google Scholar 

Brandão I, Martins MJ, Monteiro R. Metabolically Healthy Obesity-Heterogeneity in Definitions and Unconventional Factors. Metabolites. 2020;10:48.

Stefan N, Häring HU, Hu FB, Schulze MB. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol. 2013;1:152–62.

Article  PubMed  Google Scholar 

Chen C. The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci. 2004;17:1–36.

PubMed  Google Scholar 

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–97.

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–5.

Article  CAS  PubMed  Google Scholar 

Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep. Ser. 2000;894:1–253.

Google Scholar 

The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol. 1989;129:687–702.

Google Scholar 

Mørkedal B, Vatten LJ, Romundstad PR, Laugsand LE, Janszky I. Risk of myocardial infarction and heart failure among metabolically healthy but obese individuals: HUNT (Nord-Trøndelag Health Study), Norway. J Am Coll Cardiol. 2014;63:1071–8.

Article  PubMed  Google Scholar 

Caleyachetty R, Thomas GN, Toulis KA, Mohammed N, Gokhale KM, Balachandran K, et al. Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women. J Am Coll Cardiol. 2017;70:1429–37.

Article  PubMed  Google Scholar 

Patel KV, Segar MW, Lavie CJ, Kondamudi N, Neeland IJ, Almandoz JP, et al. Diabetes Status Modifies the Association Between Different Measures of Obesity and Heart Failure Risk Among Older Adults: A Pooled Analysis of Community-Based NHLBI Cohorts. Circulation. 2022;145:268–78.

Article  CAS  PubMed  Google Scholar 

Wang YC, Liang CS, Gopal DM, Ayalon N, Donohue C, Santhanakrishnan R, et al. Preclinical Systolic and Diastolic Dysfunctions in Metabolically Healthy and Unhealthy Obese Individuals. Circulation Heart Fail. 2015;8:897–904.

Article  CAS  Google Scholar 

Dobson R, Burgess MI, Sprung VS, Irwin A, Hamer M, Jones J, et al. Metabolically healthy and unhealthy obesity: differential effects on myocardial function according to metabolic syndrome, rather than obesity. Int J Obes. 2016;40:153–61.

Article  CAS  Google Scholar 

Wang Y, Liang J, Zheng S, He A, Chen C, Zhao X, et al. Combined associations of obesity and metabolic health with subclinical left ventricular dysfunctions: Danyang study. ESC heart Fail. 2021;8:3058–69.

Article  PubMed  PubMed Central  Google Scholar 

Russo C, Jin Z, Homma S, Rundek T, Elkind MS, Sacco RL, et al. Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort. J Am Coll Cardiol. 2011;57:1368–74.

Article  PubMed  PubMed Central  Google Scholar 

Russo C, Sera F, Jin Z, Palmieri V, Homma S, Rundek T, et al. Abdominal adiposity, general obesity, and subclinical systolic dysfunction in the elderly: A population-based cohort study. Eur J Heart Fail. 2016;18:537–44.

Article  PubMed  Google Scholar 

Yeboah J, Rodriguez CJ, Stacey B, Lima JA, Liu S, Carr JJ, et al. Prognosis of individuals with asymptomatic left ventricular systolic dysfunction in the multi-ethnic study of atherosclerosis (MESA). Circulation. 2012;126:2713–9.

Article  PubMed  PubMed Central  Google Scholar 

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur heart J. 2021;42:3599–726.

Article  CAS  PubMed  Google Scholar 

Miller SL, Wolfe RR. The danger of weight loss in the elderly. J Nutr Health Aging. 2008;12:487–91.

Article  CAS  PubMed  Google Scholar 

Bozkurt B. It Is Time to Screen for Heart Failure: Why and How? JACC Heart Fail. 2022;10:598–600.

Article  PubMed  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145:e895–e1032.

PubMed  Google Scholar 

Comments (0)

No login
gif