SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer

Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001;2:127–37.

Article  CAS  PubMed  Google Scholar 

Plowman GD, Green JM, Culouscou JM, Carlton GW, Rothwell VM, Buckley S. Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Nature. 1993;366:473–5.

Article  CAS  PubMed  Google Scholar 

Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, et al. ErbB receptors: from oncogenes to targeted cancer therapies. J Clin Investig. 2007;117:2051–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lenferink AE, Pinkas-Kramarski R, van de Poll ML, van Vugt MJ, Klapper LN, Tzahar E, et al. Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 1998;17:3385–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Olayioye MA, Neve RM, Lane HA, Hynes NE. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 2000;19:3159–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bargmann CI, Hung MC, Weinberg RA. The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature. 1986;319:226–30.

Article  CAS  PubMed  Google Scholar 

Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, et al. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature. 1986;319:230–4.

Article  CAS  PubMed  Google Scholar 

Iqbal N, Iqbal N. Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications. Mol Biol Int. 2014;2014:852748.

Article  PubMed  PubMed Central  Google Scholar 

Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol Cell. 2003;11:495–505.

Article  CAS  PubMed  Google Scholar 

Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, et al. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol. 1996;16:5276–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yarden Y, Pines G. The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer. 2012;12:553–63.

Article  CAS  PubMed  Google Scholar 

Shepard HM, Lewis GD, Sarup JC, Fendly BM, Maneval D, Mordenti J, et al. Monoclonal antibody therapy of human cancer: taking the HER2 protooncogene to the clinic. J Clin Immunol. 1991;11:117–27.

Article  CAS  PubMed  Google Scholar 

Pegram MD, Lipton A, Hayes DF, Weber BL, Baselga JM, Tripathy D, et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol. 1998;16:2659–71.

Article  CAS  PubMed  Google Scholar 

Tebbutt N, Pedersen MW, Johns TG. Targeting the ERBB family in cancer: couples therapy. Nat Rev Cancer. 2013;13:663–73.

Article  CAS  PubMed  Google Scholar 

Drago JZ, Ferraro E, Abuhadra N, Modi S. Beyond HER2: targeting the ErbB receptor family in breast cancer. Cancer Treat Rev. 2022;109:102436.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kinnel B, Singh SK, Oprea-Ilies G, Singh R. Targeted therapy and mechanisms of drug resistance in breast cancer. Cancers. 2023;15:1320.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jackson C, Browell D, Gautrey H, Tyson-Capper A. Clinical significance of HER-2 splice variants in breast cancer progression and drug resistance. Int J Cell Biol. 2013;2013:973584.

Article  PubMed  PubMed Central  Google Scholar 

Hart V, Gautrey H, Kirby J, Tyson-Capper A. HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes. Oncotarget. 2020;11:4338–57.

Article  PubMed  PubMed Central  Google Scholar 

Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S, Boyapati A, et al. SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell. 2011;42:185–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vukadin L, Kim JH, Park EY, Stone JK, Ungerleider N, Baddoo MC, et al. SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia. Cancer Gene Ther. 2021;28:1000–15.

Article  CAS  PubMed  Google Scholar 

Kim JH, Jeong K, Li J, Murphy JM, Vukadin L, Stone JK, et al. SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. Nat Commun. 2021;12:5551.

Article  PubMed  PubMed Central  Google Scholar 

Kim JH, Park EY, Chitayat D, Stachura DL, Schaper J, Lindstrom K, et al. SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes. Kidney Int. 2019;95:1494–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JH, Shinde DN, Reijnders MRF, Hauser NS, Belmonte RL, Wilson GR, et al. De novo mutations in SON disrupt RNA splicing of genes essential for brain development and metabolism, causing an intellectual-disability syndrome. Am J Hum Genet. 2016;99:711–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JH, Baddoo MC, Park EY, Stone JK, Park H, Butler TW, et al. SON and its alternatively spliced isoforms control MLL complex-mediated H3K4me3 and transcription of leukemia-associated genes. Mol Cell. 2016;61:859–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berdichevskii FB, Chumakov IM, Kiselev LL. [Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins]. Mol Biol. 1988;22:794–801.

CAS  Google Scholar 

Sun CT, Lo WY, Wang IH, Lo YH, Shiou SR, Lai CK, et al. Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON. J Biol Chem. 2001;276:24059–67.

Article  CAS  PubMed  Google Scholar 

Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, et al. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. Genomics. 2001;78:46–54.

Article  CAS  PubMed  Google Scholar 

Saunders LR, Barber GN. The dsRNA binding protein family: critical roles, diverse cellular functions. FASEB J. 2003;17:961–83.

Article  CAS  PubMed  Google Scholar 

Aravind L, Koonin EV. G-patch: a new conserved domain in eukaryotic RNA-processing proteins and type D retroviral polyproteins. Trends Biochem Sci. 1999;24:342–4.

Article  CAS  PubMed  Google Scholar 

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