Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench

Alipieva K, Korkina L, Orhan IE, Georgiev MI (2014) Verbascoside: a review of its occurrence, (bio)synthesis and pharmacological significance. Biotechnol Adv 32:1065–1076. https://doi.org/10.1016/j.biotechadv.2014.07.001

Article  PubMed  CAS  Google Scholar 

Alves O, Ozelim S, Magalhães L et al (2022) Acute toxicity of Stizophyllum perforatum leaves crude extract and determination of verbascoside by a validated HPLC-DAD method. Planta Med. https://doi.org/10.1055/s-0042-1759033

Article  Google Scholar 

Ambrosone L, Guerra G, Cinelli M et al (2014) Corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops. Biomed Res Int 2014:1–8. https://doi.org/10.1155/2014/471642

Article  CAS  Google Scholar 

Andary C, Wylde R, Laffite C et al (1982) Structures of verbascoside and orobanchoside, caffeic acid sugar esters from Orobanche rapum-genistae. Phytochemistry 21:1123–1127. https://doi.org/10.1016/S0031-9422(00)82429-2

Article  CAS  Google Scholar 

Anfuso CD, Giurdanella G, Longo A et al (2022) Antioxidant activity of cyanidin-3-O-glucoside and verbascoside in an in vitro model of diabetic retinopathy. Front Biosci Landmark. https://doi.org/10.31083/j.fbl2711308

Article  Google Scholar 

Anter J, Tasset I, Demyda-Peyrás S et al (2014) Evaluation of potential antigenotoxic, cytotoxic and proapoptotic effects of the olive oil by-product “alperujo”, hydroxytyrosol, tyrosol and verbascoside. Mutat Res/genet Toxicol Environ Mutagen 772:25–33. https://doi.org/10.1016/j.mrgentox.2014.07.002

Article  PubMed  CAS  Google Scholar 

Ashley D, Marasini D, Brownmiller C et al (2019) Impact of grain sorghum polyphenols on microbiota of normal weight and overweight/obese subjects during in vitro fecal fermentation. Nutrients 11:217. https://doi.org/10.3390/nu11020217

Article  PubMed  PubMed Central  CAS  Google Scholar 

Azimi H, Fallah-Tafti M, Khakshur AA, Abdollahi M (2012) A review of phytotherapy of Acne vulgaris: perspective of new pharmacological treatments. Fitoterapia 83:1306–1317. https://doi.org/10.1016/j.fitote.2012.03.026

Article  PubMed  CAS  Google Scholar 

Bahadori MB, Sarikurkcu C, Kocak MS et al (2020) Plantago lanceolata as a source of health-beneficial phytochemicals: phenolics profile and antioxidant capacity. Food Biosci 34:100536. https://doi.org/10.1016/j.fbio.2020.100536

Article  CAS  Google Scholar 

Beladjila K, Berrehal D, De Tommasi N et al (2018) New Phenylethanoid glycosides from Cistanche phelypaea and their activity as inhibitors of monoacylglycerol lipase (MAGL). Planta Med 84:710–715. https://doi.org/10.1055/s-0044-100187

Article  PubMed  CAS  Google Scholar 

Biasibetti E, Bruni N, Bigliati M, Capucchio MT (2018) Lactoferricin/verbascoside topical emulsion: a possible alternative treatment for atopic dermatitis in dogs. Nat Prod Res 32:2107–2110. https://doi.org/10.1080/14786419.2017.1365066

Article  PubMed  CAS  Google Scholar 

Bié J, Sepodes B, Fernandes PCB, Ribeiro MHL (2023) Polyphenols in health and disease: gut microbiota, bioaccessibility, and bioavailability. Compounds 3:40–72. https://doi.org/10.3390/compounds3010005

Article  CAS  Google Scholar 

Bilia AR, Piazzini V, Risaliti L et al (2019) Nanocarriers: a successful tool to increase solubility, stability and optimise bioefficacy of natural constituents. Curr Med Chem 26:4631–4656. https://doi.org/10.2174/0929867325666181101110050

Article  PubMed  CAS  Google Scholar 

Birkofer L, Kaiser C, Thomas U (1968) Acteosid und neoacteosid; zuckerester aus Syringa vulgaris (L.) 1, 2. Zeitschrift Für Naturforschung B 23:1051–1058. https://doi.org/10.1515/znb-1968-0806

Article  CAS  Google Scholar 

Boonsnongcheep P, Pichetpongtorn P, Juntosuth P et al (2022) LED and methyl jasmonate enhance a strong antioxidant compound, verbascoside, production in Clerodendrum indicum and Acanthus ebracteatus. J Plant Biochem Biotechnol 31:98–106. https://doi.org/10.1007/s13562-021-00659-z

Article  CAS  Google Scholar 

Campo G, Marchesini J, Bristot L et al (2012) The in vitro effects of verbascoside on human platelet aggregation. J Thromb Thrombolysis 34:318–325. https://doi.org/10.1007/s11239-012-0757-z

Article  PubMed  CAS  Google Scholar 

Campo G, Pavasini R, Biscaglia S et al (2015) Platelet aggregation values in patients with cardiovascular risk factors are reduced by verbascoside treatment a randomized study. Pharmacol Res 97:1–6. https://doi.org/10.1016/j.phrs.2015.03.020

Article  PubMed  CAS  Google Scholar 

Cardinali A, Linsalata V, Lattanzio V, Ferruzzi MG (2011) Verbascosides from olive mill waste water: assessment of their bioaccessibility and intestinal uptake using an in vitro digestion/caco-2 model system. J Food Sci. https://doi.org/10.1111/j.1750-3841.2010.01996.x

Article  PubMed  Google Scholar 

Cardinali A, Pati S, Minervini F et al (2012) Verbascoside, isoverbascoside, and their derivatives recovered from olive mill wastewater as possible food antioxidants. J Agric Food Chem 60:1822–1829. https://doi.org/10.1021/jf204001p

Article  PubMed  CAS  Google Scholar 

Cardinali A, Rotondo F, Minervini F et al (2013) Assessment of verbascoside absorption in human colonic tissues using the Ussing chamber model. Food Res Int 54:132–138. https://doi.org/10.1016/j.foodres.2013.06.017

Article  CAS  Google Scholar 

Carrillo-Ocampo D, Bazaldúa-Gómez S, Bonilla-Barbosa J et al (2013) Anti-Inflammatory activity of iridoids and verbascoside isolated from Castilleja tenuiflora. Molecules 18:12109–12118. https://doi.org/10.3390/molecules181012109

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cayuela JA, Rada M, Rios JJ et al (2006) Changes in Phenolic Composition Induced by Pseudomonas savastanoi pv. savastanoi infection in olive tree: presence of large amounts of verbascoside in nodules of tuberculosis disease. J Agric Food Chem 54:5363–5368. https://doi.org/10.1021/jf060807w

Article  PubMed  CAS  Google Scholar 

Chan WCW (2006) Bionanotechnology progress and advances. Biol Blood Marrow Transplant 12:87–91. https://doi.org/10.1016/j.bbmt.2005.10.004

Article  PubMed  CAS  Google Scholar 

Cheimonidi C, Samara P, Polychronopoulos P et al (2018) Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights. Redox Biol 16:169–178. https://doi.org/10.1016/j.redox.2018.02.015

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen M, Zhang Y, Huang B et al (2013) Evaluation of the antitumor activity by Ni nanoparticles with verbascoside. J Nanomater 2013:1–6. https://doi.org/10.1155/2013/623497

Article  CAS  Google Scholar 

Chen S, Liu H, Wang S et al (2022) The neuroprotection of verbascoside in Alzheimer’s disease mediated through mitigation of neuroinflammation via blocking NF-κB-p65 signaling. Nutrients 14:1417. https://doi.org/10.3390/nu14071417

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheng M, Cuda G, Bunimovich Y et al (2006) Nanotechnologies for biomolecular detection and medical diagnostics. Curr Opin Chem Biol 10:11–19. https://doi.org/10.1016/j.cbpa.2006.01.006

Article  PubMed  CAS  Google Scholar 

Chirino-Galindo G, López-Quintero I, Ramírez-Domínguez L et al (2021) Verbascoside-enriched fraction from Buddleja cordata Kunth ameliorates the effects of diabetic embryopathy in an animal model. Birth Defects Res 113:981–994. https://doi.org/10.1002/bdr2.1894

Article  PubMed  CAS  Google Scholar 

Chittasupho C, Athikomkulchai S, Samee W et al (2023) Phenylethanoid glycoside-enriched extract prepared from Clerodendrum chinense leaf inhibits A549 Lung cancer cell migration and apoptosis induction through enhancing ROS production. Antioxidants 12:461. https://doi.org/10.3390/antiox12020461

Article  PubMed 

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