Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus definitions for Sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the global burden of Disease Study. Lancet. 2020;395:200–11.

Article  PubMed  PubMed Central  Google Scholar 

Bauer M, Gerlach H, Vogelmann T, Preissing F, Stiefel J, Adam D. Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis. Crit Care. 2020;24:239.

Article  PubMed  PubMed Central  Google Scholar 

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving Sepsis Campaign: International guidelines for Management of Sepsis and Septic Shock 2021. Crit Care Med. 2021;49:e1063–143.

Article  PubMed  Google Scholar 

Rygård SL, Butler E, Granholm A, Møller MH, Cohen J, Finfer S, et al. Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis. Intensive Care Med. 2018;44:1003–16.

Article  PubMed  Google Scholar 

Fujii T, Salanti G, Belletti A, Bellomo R, Carr A, Furukawa TA, et al. Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis. Intensive Care Med. 2022;48:16–24.

Article  CAS  PubMed  Google Scholar 

Gordon AC, Mason AJ, Thirunavukkarasu N, Perkins GD, Cecconi M, Cepkova M, et al. Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH Randomized Clinical Trial. JAMA. 2016;316:509–18.

Article  CAS  PubMed  Google Scholar 

Venkatesh B, Finfer S, Cohen J, Rajbhandari D, Arabi Y, Bellomo R, et al. Adjunctive glucocorticoid therapy in patients with septic shock. N Engl J Med. 2018;378:797–808.

Article  CAS  PubMed  Google Scholar 

Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, et al. Hydrocortisone plus fludrocortisone for adults with septic shock. N Engl J Med. 2018;378:809–18.

Article  CAS  PubMed  Google Scholar 

Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288:862–71.

Article  CAS  PubMed  Google Scholar 

Annane D, Cariou A, Maxime V, Azoulay E, D’Honneur G, Timsit JF, et al. Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA. 2010;303:341–8.

Article  PubMed  Google Scholar 

Yamamoto R, Nahara I, Toyosaki M, Fukuda T, Masuda Y, Fujishima S. Hydrocortisone with fludrocortisone for septic shock: a systematic review and meta-analysis. Acute Med Surg. 2020;7:e563.

Article  PubMed  PubMed Central  Google Scholar 

Bosch NA, Teja B, Law AC, Pang B, Jafarzadeh SR, Walkey AJ. Comparative effectiveness of Fludrocortisone and hydrocortisone vs hydrocortisone alone among patients with septic shock. JAMA Intern Med. 2023;183:451–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lock AE, Gutierrez GC, Hand EO, Barthol CA, Attridge RL. Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone alone as adjunctive therapy in septic shock: a retrospective cohort study. Ann Pharmacother 2023:10600280231164210.

Beale R, Janes JM, Brunkhorst FM, Dobb G, Levy MM, Martin GS, et al. Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry. Crit Care. 2010;14:R102.

Article  PubMed  PubMed Central  Google Scholar 

Cheng X, Fu Z, Liu Y, Zheng X, Hu T. Association of mortality with fludrocortisone addition to hydrocortisone treatment among septic shock patients: a propensity score matching analysis. Front Med (Lausanne). 2023;10:1190758.

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

Article  PubMed  Google Scholar 

Wu JY, Tsai YW, Hsu WH, Liu TH, Huang PY, Chuang MH, et al. Efficacy and safety of adjunctive corticosteroids in the treatment of severe community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2023;27:274.

Article  PubMed  PubMed Central  Google Scholar 

Bauer SR, Lam SW, Cha SS, Oyen LJ. Effect of corticosteroids on arginine vasopressin-containing vasopressor therapy for septic shock: a case control study. J Crit Care. 2008;23:500–6.

Article  CAS  PubMed  Google Scholar 

Beale R, Reinhart K, Brunkhorst FM, Dobb G, Levy M, Martin G, et al. Promoting Global Research Excellence in severe Sepsis (PROGRESS): lessons from an international sepsis registry. Infection. 2009;37:222–32.

Article  CAS  PubMed  Google Scholar 

Heming N, Renault A, Kuperminc E, Brun-Buisson C, Megarbane B, Quenot JP, et al. Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial. Lancet Respir Med. 2024;12:366–74.

Article  CAS  PubMed  Google Scholar 

Lyu QQ, Chen QH, Zheng RQ, Yu JQ, Gu XH. Effect of low-dose hydrocortisone therapy in adult patients with septic shock: a Meta-analysis with Trial Sequential Analysis of Randomized controlled trials. J Intensive Care Med. 2020;35:971–83.

Article  PubMed  Google Scholar 

Archontakis Barakakis P, Palaiodimos L, Fleitas Sosa D, Benes L, Gulani P, Fein D. Combination of low-dose glucocorticosteroids and mineralocorticoids as adjunct therapy for adult patients with septic shock: a systematic review and meta-analysis of randomized trials and observational studies. Avicenna J Med. 2019;9:134–42.

Article  PubMed  PubMed Central  Google Scholar 

Heming N, Sivanandamoorthy S, Meng P, Bounab R, Annane D. Immune effects of corticosteroids in Sepsis. Front Immunol. 2018;9:1736.

Article  PubMed  PubMed Central  Google Scholar 

Hamitouche N, Comets E, Ribot M, Alvarez JC, Bellissant E, Laviolle B. Population pharmacokinetic-pharmacodynamic model of oral fludrocortisone and intravenous hydrocortisone in healthy volunteers. Aaps j. 2017;19:727–35.

Article  CAS  PubMed  Google Scholar 

Fadel F, André-Grégoire G, Gravez B, Bauvois B, Bouchet S, Sierra-Ramos C, et al. Aldosterone and Vascular Mineralocorticoid receptors in Murine Endotoxic and Human septic shock. Crit Care Med. 2017;45:e954–62.

Article  CAS  PubMed  Google Scholar