Bai L, Zhou F, Zhang L (2020) Serotonin signaling: a new player and therapeutic target beyond Long-haul coronavirus disease. MedComm 2024;5(4):e523. https://doi.org/10.1002/mco2.523. PMID: 38562420; PMCID: PMC10982457

Bakshi R, Shaikh ZA, Miletich RS, Czarnecki D, Dmochowski J, Henschel K, Janardhan V, Dubey N, Kinkel PR (2000) Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Mult Scler 6(3):181–185. https://doi.org/10.1177/135245850000600308

Article  CAS  PubMed  Google Scholar 

Barcelos IP, Troxell RM, Graves JS (2019) Mitochondrial dysfunction and multiple sclerosis. Biology 8(2):37. https://doi.org/10.3390/biology8020037

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernitsas E, Yarraguntla K, Bao F, Sood R, Santiago-Martinez C, Govindan R, Khan O, Seraji-Bozorgzad N (2017) Structural and neuronal integrity measures of fatigue severity in multiple sclerosis. Brain Sci 7(8):102. https://doi.org/10.3390/brainsci7080102

Article  PubMed  PubMed Central  Google Scholar 

Boellaard R (2009) Standards for PET image acquisition and quantitative data analysis. J Nucl Med 50(Suppl 1). https://doi.org/10.2967/jnumed.108.057182. 11S-20S

Calabrese M, Rinaldi F, Grossi P, Gallo P (2011) Cortical pathology and cognitive impairment in multiple sclerosis. Expert Rev Neurother 11(3):425–32. https://doi.org/10.1586/ern.10.155

Castro de Moura M, Davalos V, Planas-Serra L, Alvarez-Errico D, Arribas C, Ruiz M et al (2021) Epigenome-wide association study of COVID-19 severity with respiratory failure. EBioMedicine 66:103339. https://doi.org/10.1016/j.ebiom.2021.103339

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cella M, Chalder T (2010) Measuring fatigue in clinical and community settings. J Psychosom Res 69(1):17–22. https://doi.org/10.1016/j.jpsychores.2009.10.007

Article  PubMed  Google Scholar 

Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, Wallace EP (1993) Development of a fatigue scale. J Psychosom Res. 37(2):147 – 53. https://doi.org/10.1016/0022-3999(93)90081-p. PMID: 8463991

Chaudhuri A, Behan PO (2004) Fatigue in neurological disorders. Lancet 363(9413):978–988. https://doi.org/10.1016/S0140-6736(04)15794-2

Article  PubMed  Google Scholar 

Chilcot J, Norton S, Kelly ME, Moss-Morris R (2016) The chalder fatigue questionnaire is a valid and reliable measure of perceived fatigue severity in multiple sclerosis. Multiple Scler J 22(5):677–684. https://doi.org/10.1177/1352458515598019

Article  Google Scholar 

Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum Associates, Hillsdale, NJ

Google Scholar 

Compston A, Coles A (2008) Multiple sclerosis. Lancet 372(9648):1502–1517. https://doi.org/10.1016/S0140-6736(08)61620-7

Article  CAS  PubMed  Google Scholar 

Dani M, Dirksen A, Taraborrelli P, Torocastro M, Panagopoulos D, Sutton R, Lim PB (2021) Autonomic dysfunction in ‘long COVID’: rationale, physiology and management strategies. Clin Med 21(1):e63–e67. https://doi.org/10.7861/clinmed.2020-0896

Article  Google Scholar 

Derache N, Grassiot B, Mézenge F, Emmanuelle Dugué A, Desgranges B, Constans JM, Defer GL (2013) Fatigue is associated with metabolic and density alterations of cortical and deep gray matter in relapsing-remitting-multiple sclerosis patients at the earlier stage of the disease: a PET/MR study. Multiple Scler Relat Disorders 2(4):362–369. https://doi.org/10.1016/j.msard.2013.03.005

Article  Google Scholar 

Doche E, Lecocq A, Maarouf A, Duhamel G, Soulier E, Confort-Gouny S, Rico A, Guye M, Audoin B, Pelletier J, Cozzone PJ, Ranjeva JP, Zaaraoui W (2017) Hypometabolism in the posterior cingulate cortex is associated with cognitive decline in multiple sclerosis. Eur J Neurol 24(8):1079–1085. https://doi.org/10.1111/ene.13338

Article  Google Scholar 

Dressing A, Bormann T, Blazhenets G, Schroeter N, Walter LI, Thurow J, August D, Hilger H, Stete K, Gerstacker K, Arndt S, Rau A, Urbach H, Rieg S, Wagner D, Weiller C, Meyer PT, Hosp JA (2022) Neuropsychologic profiles and cerebral glucose metabolism in Neurocognitive Long COVID Syndrome. J Nucl Med Jul 63(7):1058–1063. https://doi.org/10.2967/jnumed.121.262677Epub 2021 Oct 14. PMID: 34649946; PMCID: PMC9258569

Article  CAS  Google Scholar 

Fedorowski A, Fanciulli A, Raj SR, Sheldon R, Shibao CA, Sutton R (2024) Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden. Nat Reviews Cardiol 1–2. https://doi.org/10.1038/s41569-023-00962-3

Filippi M, Bar-Or A, Piehl F, Preziosa P, Solari A, Vukusic S, Rocca MA (2018) Multiple sclerosis. Nat Reviews Disease Primers 4(1):1–27. https://doi.org/10.1038/s41572-018-0041-4

Article  Google Scholar 

Finke C, Schlichting J, Papazoglou S, Scheel M, Freing A, Soemmer C, Pech LM, Pajkert A, Pfüller C, Wuerfel JT, Ploner CJ, Paul F, Brandt AU (2015) Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue. Multiple Scler J 21(7):925–934. https://doi.org/10.1177/1352458514555784

Article  CAS  Google Scholar 

Flachenecker P, Rufer A, Bihler I, Hippel C, Reiners K, Toyka KV, Kesselring J (2003) Fatigue in MS is related to sympathetic vasomotor dysfunction. Neurology 61(6):851–853. https://doi.org/10.1212/01.wnl.0000080365.95436.b8

Article  CAS  PubMed  Google Scholar 

Garibotto V, Herholz K, Boccardi M, Picco A, Varrone A, Nordberg A, Nobili F, Ratib O (2017) Clinical validity of brain fluorodeoxyglucose positron emission tomography as a biomarker for Alzheimer’s disease in the context of a structured 5-phase development framework Neurobiology of Aging. 52:183–195. https://doi.org/10.1016/j.neurobiolaging.2016.03.033

Genova HM, Rajagopalan V, DeLuca J, Das A, Binder A, Arjunan A, Chiaravalloti N, Wylie G (2013) Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging. PLoS ONE 8(11):e78811. https://doi.org/10.1371/journal.pone.0078811

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, Guis S, Barthelemy F, Habert P, Ceccaldi M, Million M, Raoult D, Cammilleri S, Eldin C (2021) 18F-FDG brain PET hypometabolism in patients with long COVID. Eur J Nucl Med Mol Imaging 48(9):2823–2833. https://doi.org/10.1007/s00259-021-05215-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haber SN (2016) Corticostriatal circuitry. Dialog Clin Neurosci 18(1):7–21. https://doi.org/10.31887/DCNS.2016.18.1/shaber

Article  Google Scholar 

Haider L, Simeonidou C, Steinberger G, Hametner S, Grigoriadis N, Deretzi G, Lassmann H (2014) Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron. J Neurol Neurosurg Psychiatry 85(12):1386–1395. https://doi.org/10.1136/jnnp-2014-307712

Article  PubMed  Google Scholar 

Heesen C, Nawrath L, Reich C, Bauer N, Schulz KH, Gold SM (2006) Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour? J Neurol Neurosurg Psychiatry 77(1):34–39. https://doi.org/10.1136/jnnp.2005.065805

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hugon J, Msika EF, Queneau M, Farid K, Paquet C (2022) Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex. J Neurol 269(1):44–46. https://doi.org/10.1007/s00415-021-10655-x

Article  CAS  PubMed  Google Scholar 

Iglesias JE, Insausti R, Lerma-Usabiaga G, Bocchetta M, Van Leemput K, Greve DN, Alzheimer’s Disease Neuroimaging Initiative (2018) A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology. NeuroImage 183:314–326

Article  PubMed  Google Scholar 

Kedor C, Freitag H, Meyer-Arndt L, Wittke K, Hanitsch LG, Zobel A, Scheibenbogen C (2021) Chronic COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) following the first pandemic wave in Germany - a first analysis of a prospective observational study. https://doi.org/10.1101/2021.02.06.21249256. medRxiv

Kenny G, Townsend L, Savinelli S, Mallon PWG, Long COVID (2023) Clinical characteristics, proposed pathogenesis and potential therapeutic targets. Front Mol Biosci 10:1157651. https://doi.org/10.3389/fmolb.2023.1157651PMID: 37179568; PMCID: PMC10171433

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kilbaugh TJ, Karlsson M, Duhaime AC, Hansson MJ, Elmer E, Margulies SS (2015) Mitochondrial response in a toddler-aged swine model following diffuse non-impact traumatic brain injury. Mitochondrion 24:94–103. https://doi.org/10.1016/j.mito.2015.07.011

Article  Google Scholar 

Kluger BM, Krupp LB, Enoka RM (2013) Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology 80(4):409–416. https://doi.org/10.1212/WNL.0b013e31827f07be

Article  PubMed  PubMed Central  Google Scholar 

Koenigs M, Grafman J (2009) The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex. Behav Brain Res 201(2):239–243. https://doi.org/10.1016/j.bbr.2009.03.004

Article  PubMed  PubMed Central  Google Scholar 

Komaroff AL, Lipkin WI (2021) Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome. Trends Mol Med 27(9):895–906. https://doi.org/10.1016/j.molmed.2021.06.002