Berman JJ, Albores-Saavedra J, Bostwick D et al (2006) Precancer: a conceptual working definition -- results of a Consensus Conference. Cancer Detect Prev 30(5):387–394. https://doi.org/10.1016/j.cdp.2006.09.002

Klimstra DS, Hruban RH, Siegel CS, Klöppel G (2023) Tumors of the pancreas, 5 edn. American Registry of Pathology, Arlington, VA

Book  Google Scholar 

Ma H, Brosens LAA, Offerhaus GJA, Giardiello FM, de Leng WWJ, Montgomery EA (2018) Pathology and genetics of hereditary colorectal cancer. Pathology 50(1):49–59. https://doi.org/10.1016/j.pathol.2017.09.004

Article  CAS  PubMed  Google Scholar 

Kinzler KW, Vogelstein B (1997) Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386(6627):761–763. https://doi.org/10.1038/386761a0

Article  CAS  PubMed  Google Scholar 

Rosty C (2018) The role of the Surgical pathologist in the diagnosis of gastrointestinal polyposis syndromes. Adv Anat Pathol 25(1):1–13. https://doi.org/10.1097/PAP.0000000000000173

Article  PubMed  Google Scholar 

Olkinuora AP, Peltomaki PT, Aaltonen LA, Rajamaki K (2021) From APC to the genetics of hereditary and familial colon cancer syndromes. Hum Mol Genet 30(R2):R206–R24. https://doi.org/10.1093/hmg/ddab208

Article  CAS  PubMed  PubMed Central  Google Scholar 

Helderman NC, Van Der Werf-‘t Lam AS et al (2023) Msh6 Tumor G,. Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome-Associated Colorectal Carcinomas. Gastroenterology 165(1): 271-4 e2 https://doi.org/10.1053/j.gastro.2023.03.198

Helderman NC, Bajwa-Ten Broeke SW, Morreau H et al (2021) The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations. Crit Rev Oncol Hematol 163:103338. https://doi.org/10.1016/j.critrevonc.2021.103338

Article  PubMed  Google Scholar 

Valle L (2023) Lynch Syndrome: a single Hereditary Cancer Syndrome or multiple syndromes defined by different mismatch. Repair Genes? Gastroenterology 165(1):20–23. https://doi.org/10.1053/j.gastro.2023.04.027

Article  CAS  PubMed  Google Scholar 

Hsu FC, Roberts NJ, Childs E et al (2021) Risk of pancreatic Cancer among individuals with pathogenic variants in the ATM Gene. JAMA Oncol 7(11):1664–1668. https://doi.org/10.1001/jamaoncol.2021.3701

Article  PubMed  Google Scholar 

Roberts NJ, Jiao Y, Yu J et al (2012) ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov 2(1): 41 – 6 https://doi.org/10.1158/2159-8290.CD-11-0194

Roberts NJ, Norris AL, Petersen GM et al (2016) Whole genome sequencing defines the genetic heterogeneity of familial pancreatic Cancer. Cancer Discov 6(2):166–175. https://doi.org/10.1158/2159-8290.CD-15-0402

Article  CAS  PubMed  Google Scholar 

Zhen DB, Rabe KG, Gallinger S et al (2015) BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study. Genet Med 17(7):569–577. https://doi.org/10.1038/gim.2014.153

Article  CAS  PubMed  Google Scholar 

Grover S, Syngal S (2010) Hereditary pancreatic cancer. Gastroenterology 139(4): 1076-80, 80 e1-2 https://doi.org/10.1053/j.gastro.2010.08.012

Porter N, Laheru D, Lau B et al (2022) Risk of pancreatic Cancer in the long-term prospective Follow-Up of familial pancreatic Cancer kindreds. J Natl Cancer Inst 114(12):1681–1688. https://doi.org/10.1093/jnci/djac167

Article  PubMed  PubMed Central  Google Scholar 

Shindo K, Yu J, Suenaga M et al (2017) Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma. J Clin Oncol 35(30):3382–3390. https://doi.org/10.1200/JCO.2017.72.3502

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hata T, Suenaga M, Marchionni L et al (2018) Genome-wide somatic Copy number alterations and mutations in high-Grade Pancreatic Intraepithelial Neoplasia. Am J Pathol 188(7):1723–1733. https://doi.org/10.1016/j.ajpath.2018.03.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Basturk O, Hong SM, Wood LD et al (2015) A revised classification system and recommendations from the Baltimore Consensus Meeting for neoplastic precursor lesions in the pancreas. Am J Surg Pathol 39(12):1730–1741. https://doi.org/10.1097/PAS.0000000000000533

Article  PubMed  PubMed Central  Google Scholar 

Assarzadegan N, Thompson E, Salimian K et al (2021) Pathology of intraductal papillary mucinous neoplasms. Langenbecks Arch Surg 406(8):2643–2655. https://doi.org/10.1007/s00423-021-02201-0

Article  PubMed  PubMed Central  Google Scholar 

Basturk O, Adsay V, Askan G et al (2017) Intraductal Tubulopapillary Neoplasm of the pancreas: a clinicopathologic and immunohistochemical analysis of 33 cases. Am J Surg Pathol 41(3):313–325. https://doi.org/10.1097/PAS.0000000000000782

Article  PubMed  PubMed Central  Google Scholar 

Andea A, Sarkar F, Adsay VN (2003) Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol 16(10):996–1006. https://doi.org/10.1097/01.MP.0000087422.24733.62

Article  PubMed  Google Scholar 

Detlefsen S, Sipos B, Feyerabend B, Klöppel G (2005) Pancreatic fibrosis associated with age and ductal papillary hyperplasia. Virchows Arch 447(5):800–805. https://doi.org/10.1007/s00428-005-0032-1

Article  PubMed  Google Scholar 

Hiraoka N, Onozato K, Kosuge T, Hirohashi S (2006) Prevalence of FOXP3 + regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 12(18):5423–5434. https://doi.org/10.1158/1078-0432.CCR-06-0369

Article  CAS  PubMed  Google Scholar 

Pollini T, Adsay V, Capurso G et al (2022) The tumour immune microenvironment and microbiome of pancreatic intraductal papillary mucinous neoplasms. Lancet Gastroenterol Hepatol 7(12):1141–1150. https://doi.org/10.1016/S2468-1253(22)00235-7

Article  PubMed  PubMed Central  Google Scholar 

Pancreas ESGCT (2018) European evidence-based guidelines on pancreatic cystic neoplasms. Gut 67(5):789–804. https://doi.org/10.1136/gutjnl-2018-316027

Article  Google Scholar 

Kromrey ML, Bulow R, Hubner J et al (2018) Prospective study on the incidence, prevalence and 5-year pancreatic-related mortality of pancreatic cysts in a population-based study. Gut 67(1):138–145. https://doi.org/10.1136/gutjnl-2016-313127

Article  PubMed  Google Scholar 

Laffan TA, Horton KM, Klein AP et al (2008) Prevalence of unsuspected pancreatic cysts on MDCT. AJR Am J Roentgenol 191(3):802–807. https://doi.org/10.2214/AJR.07.3340

Article  PubMed  PubMed Central  Google Scholar 

Aichler M, Seiler C, Tost M et al (2012) Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol 226(5):723–734. https://doi.org/10.1002/path.3017

Article  CAS  PubMed  Google Scholar 

Singhi AD, Wood LD, Parks E et al (2020) Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct. Gastroenterology 158(3): 573 – 82 e2 https://doi.org/10.1053/j.gastro.2019.10.028

Lee JW, Hruban RH, Brosens LAA et al (2023) RNA sequencing identifies frequent mitogen-activated protein kinase-associated Fusion genes in Intraductal Tubulopapillary neoplasms of the pancreas. Gastroenterology 164(7):1310–1313. https://doi.org/10.1053/j.gastro.2023.02.006

Article  CAS  PubMed  Google Scholar 

Rabe KG, Stevens MA, Hernandez AT et al (2022) Pancreatic cancer risk to siblings of probands in bilineal cancer settings. Genet Med 24(5):1008–1016. https://doi.org/10.1016/j.gim.2022.01.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singhi AD, Ishida H, Ali SZ et al (2015) A histomorphologic comparison of familial and sporadic pancreatic cancers. Pancreatology 15(4):387–391. https://doi.org/10.1016/j.pan.2015.04.003

Article  PubMed  Google Scholar