Research ArticleVascular biology Open Access | 10.1172/JCI173690

Tianyu Song,1,2 Shuang Zhao,1,2 Shanshan Luo,1,2 Chuansheng Chen,1,2 Xingeng Liu,1,2 Xiaoqi Wu,1,2 Zhongxu Sun,1,2 Jiawei Cao,1,2 Ziyu Wang,1,2 Yineng Wang,1,2 Bo Yu,3 Zhiren Zhang,3,4 Xiaolong Du,5 Xiaoqiang Li,5 Zhijian Han,6 Hongshan Chen,1,2 Feng Chen,7 Liansheng Wang,8 Hong Wang,9 Kangyun Sun,10 Yi Han,11 Liping Xie,1,2 and Yong Ji1,2,3

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

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1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Zhao, S. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Luo, S. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Chen, C. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Liu, X. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Wu, X. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Sun, Z. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Cao, J. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Wang, Z. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Wang, Y. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Yu, B. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Zhang, Z. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Du, X. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

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1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Han, Z. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Chen, H. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Chen, F. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.

2Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

3State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), and

4Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, NHC Key Laboratory of Cell Transplantation, Harbin Medical University, China.

5Department of Vascular Surgery, The Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

6Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

7Department of Forensic Medicine, and

8Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

9Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

10Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

11Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Address correspondence to: Yong Ji or Liping Xie, Gusu School, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Ave, Jiangning District, Nanjing, Jiangsu, 211166, China. Phone: 86.451.86669473; Email: yongji@njmu.edu.cn (YJ). Phone: 86.25.86869331; Email: lipingxie@njmu.edu.cn (LX). Or to: Yi Han, Critical Care Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Rd, Nangang District, Harbin, Heilongjiang, 150086, China. Phone: 86.451.86605052; Email: yihan@hrbmu.edu.cn.

Authorship note: TS, SZ, and SL contributed equally to this work.

Find articles by Wang, L. in: JCI | PubMed | Google Scholar

1Gusu School, Nanjing Medical University, Suzhou, China.