GLOBOCAN 2020: international agency for research on cancer. Available from: https://gco.iarc.fr/today/home. Accessed 20 Mar 2023.

Tokunaga M, Kurokawa Y, Machida R, Sato Y, Takiguchi S, Doki Y, et al. Impact of postoperative complications on survival outcomes in patients with gastric cancer: exploratory analysis of a randomized controlled JCOG1001 trial. Gastric Cancer. 2021;24(1):214–23.

Article  PubMed  Google Scholar 

Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Terashima M. Poor survival rate in patients with postoperative intra-abdominal infectious complications following curative gastrectomy for gastric cancer. Ann Surg Oncol. 2013;20(5):1575–83.

Article  PubMed  Google Scholar 

Tsujimoto H, Ichikura T, Ono S, Sugasawa H, Hiraki S, Sakamoto N, et al. Impact of postoperative infection on long-term survival after potentially curative resection for gastric cancer. Ann Surg Oncol. 2019;16(2):311–8.

Article  Google Scholar 

Tu RH, Lin JX, Li P, Xie JW, Wang JB, Lu J, et al. Prognostic significance of postoperative pneumonia after curative resection for patients with gastric cancer. Cancer Med. 2017;6(12):2757–65.

Article  PubMed  PubMed Central  Google Scholar 

Kubota T, Hiki N, Sano T, Nomura S, Nunobe S, Kumagai K, et al. Prognostic significance of complications after curative surgery for gastric cancer. Ann Surg Oncol. 2014;21(3):891–8.

Article  PubMed  Google Scholar 

Pucher PH, Aggarwal R, Qurashi M, Darzi A. Meta-analysis of the effect of postoperative in-hospital morbidity on long-term patient survival. Br J Surg. 2014;101(12):1499–508.

Article  CAS  PubMed  Google Scholar 

Shimada H, Fukagawa T, Haga Y, Oba K. Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature. Ann Gastroenterol Surg. 2017;1(1):11–23.

Article  PubMed  PubMed Central  Google Scholar 

Sierzega M, Kolodziejczyk P, Kulig J, Polish Gastric Cancer Study G. Impact of anastomotic leakage on long-term survival after total gastrectomy for carcinoma of the stomach. Br J Surg. 2010;97(7):1035–42.

Article  Google Scholar 

Fujiya K, Tokunaga M, Mori K, Makuuchi R, Tanizawa Y, Bando E, et al. Long-term survival in patients with postoperative intra-abdominal infectious complications after curative gastrectomy for gastric cancer: a propensity score matching analysis. Ann Surg Oncol. 2016;23:S809–16.

Article  Google Scholar 

Andalib A, Ramana-Kumar AV, Bartlett G, Franco EL, Ferri LE. Influence of postoperative infectious complications on long-term survival of lung cancer patients: a population-based cohort study. J Thorac Oncol. 2018;8(5):554–61.

Article  Google Scholar 

Fernandez-Moreno MC, Dorcaratto D, Garces-Albir M, Munoz E, Arvizu R, Ortega J, et al. Impact of type and severity of postoperative complications on long-term outcomes after colorectal liver metastases resection. J Surg Oncol. 2020;122(2):212–25.

Article  PubMed  Google Scholar 

Bundred JR, Hollis AC, Evans R, Hodson J, Whiting JL, Griffiths EA. Impact of postoperative complications on survival after oesophagectomy for oesophageal cancer. BJS Open. 2020;4(3):405–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mrak K, Eberl T, Laske A, Jagoditsch M, Fritz J, Tschmelitsch J. Impact of postoperative complications on long-term survival after resection for rectal cancer. Dis Colon Rectum. 2013;56(1):20–8.

Article  PubMed  Google Scholar 

Jin LX, Sanford DE, Squires MH III, Moses LE, Yan Y, Poultsides GA, et al. Interaction of postoperative morbidity and receipt of adjuvant therapy on long-term survival after resection for gastric adenocarcinoma: results from the U.S. gastric cancer collaborative. Ann Surg Oncol. 2016;23(8):2398–408.

Article  PubMed  Google Scholar 

Cavassani KA, Carson WFt, Moreira AP, Wen H, Schaller MA, Ishii M, et al. The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth. Blood. 2010;115(22):4403–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eto K, Hiki N, Kumagai K, Shoji Y, Tsuda Y, Kano Y, et al. Prophylactic effect of neoadjuvant chemotherapy in gastric cancer patients with postoperative complications. Gastric Cancer. 2018;21(4):703–9.

Article  CAS  PubMed  Google Scholar 

Hayashi M, Yoshikawa T, Yura M, Otsuki S, Yamagata Y, Morita S, et al. Does neoadjuvant chemotherapy cancel out the negative survival impact induced by surgical complications after gastrectomy? Gastric Cancer. 2019;22(6):1274–84.

Article  PubMed  Google Scholar 

Kano K, Aoyama T, Yoshikawa T, Maezawa Y, Nakajima T, Hayashi T, et al. The negative survival impact of infectious complications after surgery is canceled out by the response of neoadjuvant chemotherapy in patients with esophageal cancer. Ann Surg Oncol. 2018;25(7):2034–43.

Article  PubMed  Google Scholar 

Vicente D, Ikoma N, Chiang YJ, Fournier K, Tzeng CD, Song S, et al. (2018) Preoperative therapy for gastric adenocarcinoma is protective for poor oncologic outcomes in patients with complications after gastrectomy. Ann Surg Oncol. 2018;25(9):2720–30.

Article  PubMed  Google Scholar 

Iwasaki Y, Terashima M, Mizusawa J, Katayama H, Nakamura K, Katai H, et al. Gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 gastric cancer (JCOG0501): an open-label, phase 3, randomized controlled trial. Gastric Cancer. 2021;24(2):492–502.

Article  CAS  PubMed  Google Scholar 

Japanese Gastric Cancer A. Japanese classification of gastric carcinoma – 2nd English edition. Gastric Cancer. 1998;1(1):10–24.

Article  Google Scholar 

Common terminology criteria for adverse events v3.0 (CTCAE) [Internet]. National Cancer Institute. 2006. Available from: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_archive. Accessed 20 Mar 2023.

Coccolini F, Nardi M, Montori G, Ceresoli M, Celotti A, Cascinu S, et al. Neoadjuvant chemotherapy in advanced gastric and esophago-gastric cancer. meta-analysis of randomized trials. Int J Surg. 2018;51:120–7.

Article  PubMed  Google Scholar 

Germano G, Allavena P, Mantovani A. Cytokines as a key component of cancer-related inflammation. Cytokine. 2008;43(3):374–9.

Article  CAS  PubMed  Google Scholar 

Goldfarb Y, Sorski L, Benish M, Levi B, Melamed R, Ben-Eliyahu S. Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses. Ann Surg. 2011;253(4):798–810.

Article  PubMed  Google Scholar 

Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13(12):862–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Zhang KC, Huang XH, Xi HQ, Gao YH, Liang WQ, et al. Timing of surgery after neoadjuvant chemotherapy for gastric cancer: impact on outcomes. World J Gastroenterol. 2018;24(2):257–65.

Article  PubMed  PubMed Central  Google Scholar 

Kang YK, Yook JH, Park YK, Lee JS, Kim YW, Kim JY, et al. PRODIGY: a phase III study of neoadjuvant docetaxel, oxaliplatin, and S-1 plus surgery and adjuvant S-1 versus surgery and adjuvant S-1 for resectable advanced gastric cancer. J Clin Oncol. 2021;39:11.

Article  Google Scholar 

Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355(1):10.

Article  Google Scholar 

Martin AN, Das D, Turrentine FE, Bauer TW, Adams RB, Zaydfudim VM. Morbidity and mortality after gastrectomy: identification of modifiable risk factors. J Gastrointest Surg. 2016;20(9):1554–6.

Article  PubMed  PubMed Central  Google Scholar