Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell. 2003;3(3):285–96.

Article  CAS  PubMed  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dodson M, Castro-Portuguez R, Zhang DD. Nrf2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 2019;23: 101107.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herbette S, Roeckel-Drevet P, Drevet JR. Seleno-independent glutathione peroxidases. More than simple antioxidant scavengers. FEBS J. 2007;274(9):2163–80.

Article  CAS  PubMed  Google Scholar 

Toppo S, Vanin S, Bosello V, Tosatto SC. Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily. Antioxid Redox Signal. 2008;10(9):1501–14.

Article  CAS  PubMed  Google Scholar 

Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A117a11/xCT in cancer: Ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021;12(8):599–620.

Article  CAS  PubMed  Google Scholar 

Hassannia B, Vandenabeele P, Vanden BT. Targeting ferroptosis to iron out cancer. Cancer Cell. 2019;35(6):830–49.

Article  CAS  PubMed  Google Scholar 

Hatem E, El Banna N, Huang ME. Multifaceted roles of glutathione and glutathione-based systems in carcinogenesis and anticancer drug resistance. Antioxid Redox Signal. 2017;27(15):1217–34.

Article  CAS  PubMed  Google Scholar 

Lu SC. Regulation of glutathione synthesis. Mol Aspects Med. 2009;30(1–2):42–59.

Article  CAS  PubMed  Google Scholar 

Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG, et al. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med. 2003;34(4):496–502.

Article  CAS  PubMed  Google Scholar 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Combs JA, DeNicola GM. The non-essential amino acid cysteine becomes essential for tumor proliferation and survival. Cancers. 2019;11(5):678.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koppula P, Zhang Y, Zhuang L, Gan B. Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun. 2018;38(1):12.

Article  Google Scholar 

Sharbeen G, McCarroll JA, Akerman A, Kopecky C, Youkhana J, Kokkinos J, et al. Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition. Cancer Res. 2021;81(13):3461–79.

Article  CAS  PubMed  Google Scholar 

Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88.

Article  PubMed  PubMed Central  Google Scholar 

Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y. Regulators of iron homeostasis: new players in metabolism, cell death, and disease. Trends Biochem Sci. 2016;41(3):274–86.

Article  CAS  PubMed  Google Scholar 

Salnikow K. Role of iron in cancer. Semin Cancer Biol. 2021;76:189–94.

Article  CAS  PubMed  Google Scholar 

Torti SV, Torti FM. Iron and cancer: More ore to be mined. Nat Rev Cancer. 2013;13(5):342–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018;14:507–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, et al. Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest. 2018;128:3341–55.

Article  PubMed  PubMed Central  Google Scholar 

Wei R, Zhao Y, Wang J, Yang X, Li S, Wang Y, et al. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. Int J Biol Sci. 2021;17(11):2703–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan HF, Zou T, Tuo QZ, Xu S, Li H, Belaidi AA, et al. Ferroptosis: mechanisms and links with diseases. Signal Transduct Target Ther. 2021;6(1):49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Kang R, Kroemer G, Tang D. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18(5):280–96.

Article  CAS  PubMed  Google Scholar 

Zhang C, Liu X, Jin S, Chen Y, Guo R. Ferroptosis in cancer therapy: a novel approach to reversing drug resistance. Mol Cancer. 2022;21(1):47.

Article  PubMed  PubMed Central  Google Scholar 

Du Y, Guo Z. Recent progress in ferroptosis: inducers and inhibitors. Cell Death Discov. 2022;8:501.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leeya Y, Mulvany MJ, Queiroz EF, Marston A, Hostettmann K, Jansakul C. Hypotensive activity of an n-butanol extract and their purified compounds from leaves of Phyllanthus acidus (L.) skeels in rats. Eur J Pharmacol. 2010;649(1–3):301–13.

Article  CAS  PubMed  Google Scholar 

Tan SP, Tan EN, Lim QY, Nafiah MA. Phyllanthus acidus (L.) skeels: a review of its traditional uses, phytochemistry, and pharmacological properties. J Ethnopharmacol. 2020;253:112610.

Article  CAS  PubMed  Google Scholar 

Geng HC, Zhu HT, Wang D, Yang WN, Yang CR, Zhang YJ. Phyllanacidins aA-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities. Fitoterapia. 2021;148: 104793.

Article  CAS  PubMed  Google Scholar 

Geng HC, Zhu HT, Yang WN, Wang D, Yang CR, Zhang YJ. New cytotoxic dichapetalins in the leaves of Phyllanthus acidus: Identification, quantitative analysis, and preliminary toxicity assessment. Bioorg Chem. 2021;114: 105125.

Article