Rotella DP. The discovery and development of boceprevir. Expert Opin Drug Discov. 2013;8:1439–47.

Article  CAS  PubMed  Google Scholar 

Rizza SA, Talwani R, Nehra V, Temesgen Z. Boceprevir. Drugs Today Barc Spain. 2011;47:743–51.

Article  CAS  Google Scholar 

Wolleb H, Carreira EM. Total Synthesis of (+)-Dendrowardol C. Angew Chem Int Ed. 2017;56:10890–3.

Article  CAS  Google Scholar 

Zhao N, Xie S, Tian P, Tong R, Ning C, Xu J. Asymmetric total synthesis of (+)-astellatol and (−)-astellatene. Org Chem Front. 2019;6:2014–22.

Article  CAS  Google Scholar 

Chuang H-Y, Isobe M. Novel synthesis of right segment of solanoeclepin A org. Lett. 2014;16:4166–9.

CAS  Google Scholar 

Komada T, Adachi M, Nishikawa T. A concise synthesis of a highly strained cyclobutane in solanoeclepin A by radical cyclization. Chem Lett. 2012;41:287–9.

Article  CAS  Google Scholar 

Gao M, Wang Y-C, Yang K-R, He W, Yang X-L, Yao Z-J. Enantioselective total synthesis of (++)-plumisclerin A. Angew Chem Int Ed. 2018;57:13313–8.

Article  CAS  Google Scholar 

Tsao K-W, Cheng C-Y, Isobe M. Cobalt-mediated synthesis of the tricyclo[5.2.1.01,6]decene framework in solanoeclepin A. Org Lett. 2012;14:5274–7.

Article  CAS  PubMed  Google Scholar 

Zhang W. Discovery and development of cyclobutanone-based free radical ring expansion and annulation reactions. Curr Org Chem. 2002;6:1015–29.

Article  CAS  Google Scholar 

Zhao N, Yin S, Xie S, Yan H, Ren P, Chen G, Chen F, Xu J. Total synthesis of astellatol. Angew Chem Int Ed. 2018;57:3386–90.

Article  CAS  Google Scholar 

Nugent WA, RajanBabu TV. Transition-metal-centered radicals in organic synthesis. Titanium(III)-induced cyclization of epoxy olefins. J Am Chem Soc. 1988;110:8561–2.

Article  CAS  Google Scholar 

RajanBabu TV, Nugent WA. Intermolecular addition of epoxides to activated olefins: a new reaction. J Am Chem Soc. 1989;111:4525–7.

Article  CAS  Google Scholar 

RajanBabu TV, Nugent WA. Selective generation of free radicals from epoxides using a transition-metal radical. A powerful new tool for organic synthesis. J Am Chem Soc. 1994;116:986–97.

Article  CAS  Google Scholar 

Gansäuer A, Greb A, Huth I, Worgull D, Knebel K. Formal total synthesis of (±)-fragranol via template catalyzed 4-exo cyclization. Tetrahedron. 2009;65:10791–6.

Article  Google Scholar 

Knölker H-J, Schmitt O, Wanzl G, Baum G. Stereoselective total synthesis of (±)-fragranol by TiCl4 promoted [2+2] cycloaddition of allyl-tert-butyldiphenylsilane and methyl methacrylate. Chem Commun. 1999. https://doi.org/10.1039/A905019A.

Article  Google Scholar 

Lu P, Bach T. Total synthesis of (+)-lactiflorin by an intramolecular [2+2] photocycloaddition. Angew Chem Int Ed. 2012;51:1261–4.

Article  CAS  Google Scholar 

Sarkar D, Bera N, Ghosh S. [2+2] Photochemical cycloaddition in organic synthesis. Eur J Org Chem. 2020;2020:1310–26.

Article  CAS  Google Scholar 

Bell JD, Murphy JA. Recent advances in visible light-activated radical coupling reactions triggered by (i) ruthenium, (ii) iridium and (iii) organic photoredox agents. Chem Soc Rev. 2021;50:9540–685.

Article  CAS  PubMed  Google Scholar 

Guo R, Brown MK. Lewis acid-promoted [2+2] cycloadditions of allenes and ketenes: versatile methods for natural product synthesis. Acc Chem Res. 2023;56:2253–64.

Article  CAS  PubMed  Google Scholar 

Alcaide B, Almendros P, Aragoncillo C. Exploiting [2+2] cycloaddition chemistry: achievements with allenes. Chem Soc Rev. 2010;39:783–816.

Article  CAS  PubMed  Google Scholar 

Richardson AD, Vogel TR, Traficante EF, Glover KJ, Schindler CS. Total synthesis of (+)-cochlearol B by an approach based on a catellani reaction and visible-light-enabled [2+2] cycloaddition. Angew Chem Int Ed. 2022;134: e202201213.

Article  Google Scholar 

Liu R, Zhang M, Wyche TP, Winston-McPherson GN, Bugni TS, Tang W. Stereoselective preparation of cyclobutanes with four different substituents: total synthesis and structural revision of pipercyclobutanamide A and piperchabamide G. Angew Chem Int Ed. 2012;124:7621–4.

Article  Google Scholar 

Panish RA, Chintala SR, Fox JM. A Mixed-ligand chiral rhodium(II) catalyst enables the enantioselective total synthesis of piperarborenine B. Angew Chem Int Ed. 2016;128:5067–71.

Article  Google Scholar 

Fu C, Zhang Y, Xuan J, Zhu C, Wang B, Ding H. Diastereoselective total synthesis of salvileucalin C. Org Lett. 2014;16:3376–9.

Article  CAS  PubMed  Google Scholar 

Drew SL, Lawrence AL, Sherburn MS. Total synthesis of kingianins A, D, and F. Angew Chem Int Ed. 2013;52:4221–4.

Article  CAS  Google Scholar 

Baran PS, Richter JM. Enantioselective total syntheses of welwitindolinone A and fischerindoles I and G. J Am Chem Soc. 2005;127:15394–6.

Article  CAS  PubMed  Google Scholar 

Woodward RB, Hoffmann R. The conservation of orbital symmetry. Angew Chem Int Ed. 1969;8:781–853.

Article  CAS  Google Scholar 

Burke LA. Theoretical study of [2+2] cycloadditions. Ketene with ethylene. J Org Chem. 1985;50:3149–55.

Article  CAS  Google Scholar 

McCaleb KL, Halcomb RL. Intramolecular ketene−allene cycloadditions. Org Lett. 2000;2:2631–4.

Article  CAS  PubMed  Google Scholar 

Wang Y, Wei D, Li Z, Zhu Y, Tang M. DFT study on the mechanisms and diastereoselectivities of Lewis acid-promoted ketene-alkene [2+2] cycloadditions: what is the role of lewis acid in the ketene and C=X (X = O, CH2, and NH) [2+2] cycloaddition reactions? J Phys Chem A. 2014;118:4288–300.

Article  CAS  PubMed  Google Scholar 

Huang W, Tidwell TT. Allenylketenes: versatile substrates in nucleophilic, electrophilic, and cycloaddition reactions. Synthesis. 2000;2000:457–70.

Article  Google Scholar 

Fu N, Tidwell TT. Preparation of β-lactams by [2+2] cycloaddition of ketenes and imines. Tetrahedron. 2008;64:10465–96.

Article  CAS  Google Scholar 

Salzner U, Bachrach SM. Cycloaddition reactions between cyclopentadiene and ketene. Ab initio examination of [2+2] and [4+2] pathways. J Org Chem. 1996;61:237–42.

Article  CAS  Google Scholar 

Yamabe S, Kuwata K, Minato T. Frontier-orbital analyses of ketene [2+2] cycloadditions. Theor Chem Acc. 1999;102:139–46.

Article  CAS  Google Scholar 

Rasik CM, Brown MK. Total synthesis of Gracilioether F: development and application of lewis acid promoted ketene-alkene [2+2] cycloadditions and late-stage C–H oxidation. Angew Chem Int Ed. 2014;53:14522–6.

Article  CAS  Google Scholar 

Rullière P, Cannillo A, Grisel J, Cividino P, Carret S, Poisson JF. Total synthesis of proteasome inhibitor (−)-omuralide through asymmetric ketene [2+2]-cycloaddition. Org Lett. 2018;20:4558–61.

Article  PubMed  Google Scholar 

Snider BB, Beal RB. Total synthesis of sesquiterpenes via intramolecular ketene cycloadditions: isocomene and α-cis- and α-trans-bergamotenes, an approach to seychellene. J Org Chem. 1988;53:4508–15.

Article  CAS  Google Scholar 

Boulton LT, Brick D, Fox ME, Jackson M, Lennon IC, McCague R, Parkin N, Rhodes D, Ruecroft G. Synthesi