eEF1A1 regulates the expression and alternative splicing of genes associated with Parkinson’s disease in U251 cells

Akintade DD, Chaudhuri B (2020) Identification of proteins involved in transcription/translation (eEF 1A1) as an inhibitor of Bax induced apoptosis. Mol Biol Rep 47:6785–6792

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alieva A, Rudenok M, Filatova E, Karabanov A, Doronina O, Doronina K, Kolacheva A, Ugrumov M, Illarioshkin S, Slominsky P, Shadrina M (2020) VCP expression decrease as a biomarker of preclinical and early clinical stages of Parkinson’s disease. Sci Rep 10:827

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK (2013) GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacol Ther 138:155–175

Article  CAS  PubMed  Google Scholar 

Beckelman BC, Zhou X, Keene CD, Ma T (2016) Impaired eukaryotic elongation factor 1A expression in Alzheimer’s Disease. Neurodegener Dis 16:39–43

Article  CAS  PubMed  Google Scholar 

Belarbi K, Cuvelier E, Bonte MA, Desplanque M, Gressier B, DEVOS D, Chartier-Harlin MC (2020) Glycosphingolipids and neuroinflammation in Parkinson’s disease. Mol Neurodegener 15:59

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berry A, Bindocci E, Alleva E (2012) NGF, brain and behavioral plasticity. Neural Plast 2012:784040

Article  PubMed  PubMed Central  Google Scholar 

Bloem BR, Okun MS, Klein C (2021) Parkinson’s disease. Lancet 397:2284–2303

Article  CAS  PubMed  Google Scholar 

Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto ET, Ory DS, Schaffer JE (2006) A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol Biol Cell 17:770–778

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wolynska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, Burbulla LF, Massart F, Bohler J, Cruciani G, Schmid B, Kurz-Drexler A, May P, Duga S, Klein C, Schwamborn JC, Marcus K, Woitalla D, Weisenhorn V, Wurst DM, Baralle W, Krainc M, Gasser D, Wissinger T, B., Kruger R (2020) A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease. Sci Transl Med, 12

Cacabelos R (2017) Parkinson’s Disease: From Pathogenesis to Pharmacogenomics. Int J Mol Sci, 18

Chalorak P, Dharmasaroja P, Meemon K (2020) Downregulation of eEF1A/EFT3-4 enhances dopaminergic Neurodegeneration after 6-OHDA exposure in C. Elegans Model. Front Neurosci 14:303

Article  PubMed  PubMed Central  Google Scholar 

Consortium HDI (2012) Induced pluripotent stem cells from patients with Huntington’s disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11:264–278

Article  Google Scholar 

Duke DC, Moran LB, Pearce RK, Graeber MB (2007) The medial and lateral substantia nigra in Parkinson’s disease: mRNA profiles associated with higher brain tissue vulnerability. Neurogenetics 8:83–94

Article  CAS  PubMed  Google Scholar 

Ellis JM, Wong GW, Wolfgang MJ (2013) Acyl coenzyme a thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol Cell Biol 33:1869–1882

Article  CAS  PubMed  PubMed Central  Google Scholar 

Escande-Beillard N, Loh A, Saleem SN, Kanata K, Hashimoto Y, Altunoglu U, Metoska A, Grandjean J, Ng FM, Pomp O, Baburajendran N, Wong J, Hill J, Beillard E, Cozzone P, Zaki M, Kayserili H, Hamada H, Shiratori H, Reversade B (2020) Loss of PYCR2 causes neurodegeneration by increasing cerebral Glycine levels via SHMT2. Neuron 107:82–94 e6

Article  CAS  PubMed  Google Scholar 

Garcia-Esparcia P, Hernández-Ortega K, Koneti A, Gil L, Delgado-Morales R, Castaño E, Carmona M, Ferrer I (2015) Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease. Acta Neuropathol Commun 3:76

Article  PubMed  PubMed Central  Google Scholar 

George G, Singh S, Lokappa SB, Varkey J (2019) Gene co-expression network analysis for identifying genetic markers in Parkinson’s disease - a three-way comparative approach. Genomics 111:819–830

Article  CAS  PubMed  Google Scholar 

Green HF, Khosousi S, Svenningsson P (2019) Plasma IL-6 and IL-17A correlate with severity of motor and non-motor symptoms in Parkinson’s Disease. J Parkinsons Dis 9:705–709

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hofmann KW, Schuh AF, Saute J, Townsend R, Fricke D, Leke R, Souza DO, Portela LV, Chaves ML, Rieder CR (2009) Interleukin-6 serum levels in patients with Parkinson’s disease. Neurochem Res 34:1401–1404

Article  CAS  PubMed  Google Scholar 

Jakubauskiene E, Kanopka A (2021) Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases. Genes (Basel), 12

Jin L, Li G, Yu D, Huang W, Cheng C, Liao S, Wu Q, Zhang Y (2017) Transcriptome analysis reveals the complexity of alternative splicing regulation in the fungus verticillium dahliae. BMC Genomics 18:130

Article  PubMed  PubMed Central  Google Scholar 

Khwanraj K, Madlah S, Grataitong K, Dharmasaroja P (2016) Comparative mRNA expression of eEF1A isoforms and a PI3K/Akt/mTOR pathway in a Cellular Model of Parkinson’s Disease. Parkinsons Dis 2016:8716016

PubMed  PubMed Central  Google Scholar 

Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL (2013) TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol 14:R36

Article  PubMed  PubMed Central  Google Scholar 

Kim D, Kwon S, Jeon H, Ryu S, Ha KT, Kim S (2018) Proteomic change by Korean Red Ginseng in the substantia nigra of a Parkinson’s disease mouse model. J Ginseng Res 42:429–435

Article  PubMed  Google Scholar 

La Cognata V, D’agata V, Cavalcanti F, Cavallaro S (2015) Splicing: is there an alternative contribution to Parkinson’s disease? Neurogenetics 16:245–263

Article  PubMed  PubMed Central  Google Scholar 

Larsen K, Baek R, Sahin C, Kjaer L, Christiansen G, Nielsen J, Farajzadeh L, Otzen DE (2021) Molecular characteristics of porcine alpha-synuclein splicing variants. Biochimie 180:121–133

Article  CAS  PubMed  Google Scholar 

Lee KT, Byun MJ, Kang KS, Park EW, Lee SH, Cho S, Kim H, Kim KW, Lee T, Park JE, Park W, Shin D, Park HS, Jeon JT, Choi BH, Jang GW, Choi SH, Kim DW, Lim D, Park HS, Park MR, Ott J, Schook LB, Kim TH, Kim H (2011) Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study. PLoS ONE 6:e16356

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lian C, Huang Q, Zhong X, He Z, Liu B, Zeng H, Xu N, Yang Z, Liao C, Fu Z, Guo H (2021) PTX3 secreted by human adipose-derived stem cells promotes dopaminergic neuron repair in Parkinson’s disease via inhibiting apoptosis

Licker V, Turck N, Kövari E, Burkhardt K, Côte M, Surini-Demiri M, Lobrinus JA, Sanchez JC, Burkhard PR (2014) Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson’s disease pathogenesis. Proteomics 14:784–794

Article  CAS  PubMed  Google Scholar 

Liu Y, Jiang S, Yang PY, Zhang YF, Li TJ, Rui YC (2016) EF1A1/HSC70 cooperatively suppress brain endothelial cell apoptosis via regulating JNK activity. CNS Neurosci Ther 22:836–844

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr., Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O (2019) METTL13 methylation of eEF1A increases translational output to promote tumorigenesis. Cell 176:491–504e21

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Deng S, Song Z, Zhang Q, Guo Y, Yu Y, Wang Y, Li T, Megahed FAK, Addissouky TA, Mao J, Zhang Y (2021) MLIF modulates Microglia polarization in ischemic stroke by targeting eEF1A1. Front Pharmacol 12:725268

Article  CAS  PubMed  PubMed Central 

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