YTHDF2 Regulates Advanced Glycation End Products-Induced Melanogenesis through Inhibiting A20 Expression in Human Dermal Fibroblasts

Lee, A.Y. 2021. Skin pigmentation abnormalities and their possible relationship with skin aging. International Journal of Molecular Sciences 22 (7): 3727.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim, J.C., T.J. Park, and H.Y. Kang. 2022. Skin-aging pigmentation: who is the real enemy? Cells 11 (16): 2541.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bastonini, E., D. Kovacs, and M. Picardo. 2016. Skin pigmentation and pigmentary disorders: focus on epidermal/dermal cross-talk. Annals of Dermatology 28 (3): 279–289.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poon, F., S. Kang, and A.L. Chien. 2015. Mechanisms and treatments of photoaging. Photodermatology, Photoimmunology and Photomedicine 31 (2): 65–74.

Article  CAS  PubMed  Google Scholar 

Xu, X., Y. Zheng, Y. Huang, J. Chen, Z. Gong, Y. Li, C. Lu, W. Lai, and Q. Xu. 2018. Cathepsin D contributes to the accumulation of advanced glycation end products during photoaging. Journal of Dermatological Science 90 (3): 263–275.

Article  CAS  PubMed  Google Scholar 

Fang, J., M. Ouyang, Y. Qu, M. Wang, X. Huang, J. Lan, W. Lai, and Q. Xu. 2022. Advanced glycation end products promote melanogenesis by activating NLRP3 inflammasome in human dermal fibroblasts. The Journal of Investigative Dermatology 142 (10): 2591-2602.e8.

Article  CAS  PubMed  Google Scholar 

Wang, M., X. Huang, M. Ouyang, J. Lan, J. Huang, H. Li, W. Lai, Y. Gao, and Q. Xu. 2023. A20 ameliorates advanced glycation end products-induced melanogenesis by inhibiting NLRP3 inflammasome activation in human dermal fibroblasts. Journal of Dermatological Science S0923–1811 (23): 00187–00191.

Google Scholar 

Catrysse, L., L. Vereecke, R. Beyaert, and G. van Loo. 2014. A20 in inflammation and autoimmunity. Trends in Immunology 35 (1): 22–31.

Article  CAS  PubMed  Google Scholar 

Mele, A., J.R. Cervantes, V. Chien, D. Friedman, and C. Ferran. 2014. Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases. Advances in Experimental Medicine and Biology 809: 163–183.

Article  PubMed  Google Scholar 

Hsu, A.C., K. Dua, M.R. Starkey, T.J. Haw, P.M. Nair, K. Nichol, N. Zammit, S.T. Grey, K.J. Baines, P.S. Foster, P.M. Hansbro, and P.A. Wark. 2017. MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD. JCI Insight. 2 (7): e90443.

Article  PubMed  PubMed Central  Google Scholar 

Tiruppathi, C., D. Soni, D.M. Wang, J. Xue, V. Singh, P.B. Thippegowda, B.P. Cheppudira, R.K. Mishra, A. Debroy, Z. Qian, K. Bachmaier, Y.Y. Zhao, J.W. Christman, S.M. Vogel, A. Ma, and A.B. Malik. 2014. The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. Nature Immunology 15 (3): 239–247.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Momtazi, G., B.N. Lambrecht, J.R. Naranjo, and B.C. Schock. 2019. Regulators of A20 (TNFAIP3): New drug-able targets in inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology 316 (3): L456–L469.

Article  CAS  PubMed  Google Scholar 

Meyer, K.D., Y. Saletore, P. Zumbo, O. Elemento, C.E. Mason, and S.R. Jaffrey. 2012. Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons. Cell 149 (7): 1635–1646.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dominissini, D., S. Moshitch-Moshkovitz, S. Schwartz, M. Salmon-Divon, L. Ungar, S. Osenberg, K. Cesarkas, J. Jacob-Hirsch, N. Amariglio, M. Kupiec, R. Sorek, and G. Rechavi. 2012. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485 (7397): 201–206.

Article  CAS  PubMed  Google Scholar 

Wang, X., Z. Lu, A. Gomez, G.C. Hon, Y. Yue, D. Han, Y. Fu, M. Parisien, Q. Dai, G. Jia, B. Ren, T. Pan, and C. He. 2014. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505 (7481): 117–120.

Article  PubMed  Google Scholar 

Li, F., D. Zhao, J. Wu, and Y. Shi. 2014. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. Cell Research 24 (12): 1490–1492.

Article  PubMed  PubMed Central  Google Scholar 

Du, H., Y. Zhao, J. He, Y. Zhang, H. Xi, M. Liu, J. Ma, and L. Wu. 2016. YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex. Nature Communications 7: 12626.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, Y., Y.L. Wang, K. Qiu, Y.Q. Cao, F.J. Zhang, H.B. Zhao, and X.Z. Liu. 2022. YTHDF2 promotes temozolomide resistance in glioblastoma by activation of the Akt and NF-κB signalling pathways via inhibiting EPHB3 and TNFAIP3. Clinical & Translational Immunology 11 (5): e1393.

Article  CAS  Google Scholar 

Ouyang, M., J. Fang, M. Wang, X. Huang, J. Lan, Y. Qu, W. Lai, and Q. Xu. 2022. Advanced glycation end products alter the m6A-modified RNA profiles in human dermal fibroblasts. Epigenomics 14 (8): 431–449.

Article  CAS  PubMed  Google Scholar 

Fang, C., M. He, D. Li, and Q. Xu. 2021. YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways. Cellular Signalling 85: 110060.

Article  CAS  PubMed  Google Scholar 

Yu, R., Q. Li, Z. Feng, L. Cai, and Q. Xu. 2019. m6A Reader YTHDF2 Regulates LPS-induced inflammatory response. International Journal of Molecular Sciences 20 (6): 1323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ott, C., K. Jacobs, E. Haucke, A. Navarrete Santos, T. Grune, and A. Simm. 2014. Role of advanced glycation end products in cellular signaling. Redox Biology 2: 411–429.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bauernfeind, F.G., G. Horvath, A. Stutz, E.S. Alnemri, K. MacDonald, D. Speert, T. Fernandes-Alnemri, J. Wu, B.G. Monks, K.A. Fitzgerald, V. Hornung, and E. Latz. 2009. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. The Journal of Immunology 183 (2): 787–791.

Article  CAS  PubMed  Google Scholar 

Zhou, J., J. Ling, Y. Wang, J. Shang, and F. Ping. 2016. Cross-talk between interferon-gamma and interleukin-18 in melanogenesis. Journal of Photochemistry and Photobiology B: Biology 163: 133–143.

Article  CAS  PubMed  Google Scholar 

Zhou, J., J. Shang, J. Song, and F. Ping. 2013. Interleukin-18 augments growth ability of primary human melanocytes by PTEN inactivation through the AKT/NF-κB pathway. International Journal of Biochemistry & Cell Biology 45 (2): 308–316.

Article  CAS  Google Scholar 

Krikos, A., C.D. Laherty, and V.M. Dixit. 1992. Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. Journal of Biological Chemistry 267 (25): 17971–17976.

Article  CAS  PubMed  Google Scholar 

He, K.L., and A.T. Ting. 2002. A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Molecular and Cellular Biology 22: 6034–6045.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, L., C. Qi, Y. Liu, Y. Shen, X. Zhao, H. Qin, Y. Zhang, and T. Yu. 2021. MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3). Bioengineered 12 (2): 9902–9913.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao, H., L. Wang, H. Luo, Q.Z. Li, and X. Zuo. 2017. TNFAIP3 downregulation mediated by histone modification contributes to T-cell dysfunction in systemic lupus erythematosus. Rheumatology (Oxford) 56 (5): 835–843.

Article 

Comments (0)

No login
gif