Levi M, van der Poll T. Coagulation and sepsis. Thromb Res. 2017;149:38–44. https://doi.org/10.1016/j.thromres.2016.11.007.
Article CAS PubMed Google Scholar
Kinasewitz GT, Yan SB, Basson B, et al. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care (Lond Engl). 2004;8:R82–90. https://doi.org/10.1186/cc2459.
Winer LK, Salyer C, Beckmann N, Caldwell CC, Nomellini V. Enigmatic role of coagulopathy among sepsis survivors: a review of coagulation abnormalities and their possible link to chronic critical illness. Trauma Surg Acute Care Open. 2020;5:e000462. https://doi.org/10.1136/tsaco-2020-000462.
Schmoch T, Möhnle P, Weigand MA, et al. The prevalence of sepsis-induced coagulopathy in patients with sepsis - a secondary analysis of two German multicenter randomized controlled trials. Ann Intensive Care. 2023;13:3. https://doi.org/10.1186/s13613-022-01093-7.
Article CAS PubMed PubMed Central Google Scholar
Iba T, Levy JH. Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis. J Thromb Haemost. 2018;16:231–41. https://doi.org/10.1111/jth.13911.
Simmons J, Pittet JF. The coagulopathy of acute sepsis. Curr Opin Anaesthesiol. 2015;28:227–36. https://doi.org/10.1097/ACO.0000000000000163.
Article CAS PubMed PubMed Central Google Scholar
Delabranche X, Helms J, Meziani F. Immunohaemostasis: a new view on haemostasis during sepsis. Ann Intensive Care. 2017;7:117. https://doi.org/10.1186/s13613-017-0339-5.
Article CAS PubMed PubMed Central Google Scholar
Czempik PF, Wiórek A. Management strategies in septic coagulopathy: a review of the current literature. Healthcare (Basel Switz). https://doi.org/10.3390/healthcare11020227.
Levi M, Schultz M, van der Poll T. Sepsis and thrombosis. Semin Thromb Hemost. 2013;39:559–66. https://doi.org/10.1055/s-0033-1343894.
Article CAS PubMed Google Scholar
Semeraro N, Ammollo CT, Semeraro F, Colucci M. Sepsis, thrombosis and organ dysfunction. Thromb Res. 2012;129:290–5. https://doi.org/10.1016/j.thromres.2011.10.013.
Article CAS PubMed Google Scholar
Bleiblo F, Michael P, Brabant D, Ramana CV, Tai T, Saleh M, Parrillo JE, Kumar A, Kumar A. The role of immunostimulatory nucleic acids in septic shock. Int J Clin Exp Med. 2012;5:1–23.
Lupu F. “Crossroads in sepsis research” Review series overview of the pathophysiology of sepsis. J Cell Mol Med. 2008;12:1072–3. https://doi.org/10.1111/j.1582-4934.2008.00366.x.
Abrams ST, Morton B, Alhamdi Y, Alsabani M, Lane S, Welters ID, et al. A novel assay for neutrophil extracellular trap formation independently predicts disseminated intravascular coagulation and mortality in critically ill patients. Am J Respir Crit Care Med. 2019;200:869–80. https://doi.org/10.1164/rccm.201811-2111OC.
Yu X, Tan J, Diamond SL. Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions. J Thromb Haemost. 2018;16:316–29. https://doi.org/10.1111/jth.13907.
Delabranche X, Stiel L, Severac F, et al. Evidence of netosis in septic shock-induced disseminated intravascular coagulation. Shock (Augusta Ga). 2017;47:313–7. https://doi.org/10.1097/SHK.0000000000000719.
Kambas K, Mitroulis I, Apostolidou E, et al. Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis. PLoS ONE. 2012;7: e45427. https://doi.org/10.1371/journal.pone.0045427.
Article CAS PubMed PubMed Central Google Scholar
van Vught LA, Uhel F, Ding C, et al. Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis. J Thromb Haemost. 2021;19:1049–63. https://doi.org/10.1111/jth.15246.
Muronoi T, Koyama K, Nunomiya S, Lefor AK, Wada M, Koinuma T, et al. Immature platelet fraction predicts coagulopathy-related platelet consumption and mortality in patients with sepsis. Thromb Res. 2016;144:169–75. https://doi.org/10.1016/j.thromres.2016.06.002.
Scarlatescu E, Tomescu D, Arama SS. Sepsis-associated coagulopathy. J. Crit Care Med. 2016;2:156–63. https://doi.org/10.1515/jccm-2016-0024.
Levi M, Keller TT, van Gorp E, ten Cate H. Infection and inflammation and the coagulation system. Cardiovasc Res. 2003;60:26–39. https://doi.org/10.1016/s0008-6363(02)00857-x.
Article CAS PubMed Google Scholar
Levy JH, Sniecinski RM, Welsby IJ, Levi M. Antithrombin: anti-inflammatory properties and clinical applications. Thromb Haemost. 2016;115:712–28. https://doi.org/10.1160/TH15-08-0687.
• Lupu F, Kinasewitz G, Dormer K. The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis. J Cell Mol Med. 2020;24:12258–71. https://doi.org/10.1111/jcmm.15895. This review offers insights into the influence of endothelial shear stress on various aspects such as hemodynamics, inflammation, and coagulation during sepsis.
Riewald M, Ruf W. Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem. 2005;280:19808–14. https://doi.org/10.1074/jbc.M500747200.
Article CAS PubMed Google Scholar
Carey MJ, Rodgers GM. Disseminated intravascular coagulation: clinical and laboratory aspects. Am J Hematol. 1998;59:65–73. https://doi.org/10.1002/(sici)1096-8652(199809)59:1<65::aid-ajh13>3.0.co;2-0.
Semeraro N, Ammollo CT, Semeraro F, Colucci M. Sepsis-associated disseminated intravascular coagulation and thromboembolic disease. Mediterr J Hematol Infect Dis. 2010;2:e2010024. https://doi.org/10.4084/MJHID.2010.024.
Okamoto K, Tamura T, Sawatsubashi Y. Sepsis and disseminated intravascular coagulation. J Intensive Care. 2016;4:23. https://doi.org/10.1186/s40560-016-0149-0.
Article PubMed PubMed Central Google Scholar
Iba T, Levy JH. Sepsis-induced coagulopathy and disseminated intravascular coagulation. Anesthesiology. 2020;132:1238–45. https://doi.org/10.1097/ALN.0000000000003122.
Taylor FB, Toh CH, Hoots WK, Wada H, Levi M, Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86:1327–30.
Gando S, Wada H, Asakura H, et al. Evaluation of new Japanese diagnostic criteria for disseminated intravascular coagulation in critically ill patients. Clin Appl Thromb. 2005;11:71–6. https://doi.org/10.1177/107602960501100108.
Frank CS, Larsen JB. Prognostic impact of the international society on thrombosis and hemostasis disseminated intravascular coagulation score in sepsis: a systematic review. Semin Thromb Hemost. 2023;49:471–87. https://doi.org/10.1055/s-0043-1761216.
Article CAS PubMed Google Scholar
Umemura Y, Yamakawa K, Hayakawa M, Hamasaki T, Fujimi S, Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group. Screening itself for disseminated intravascular coagulation may reduce mortality in sepsis: a nationwide multicenter registry in Japan. Thromb Res. 2018;161:60–6. https://doi.org/10.1016/j.thromres.2017.11.023.
Iba T, Umemura Y, Watanabe E, Wada T, Hayashida K, Kushimoto S. Diagnosis of sepsis-induced disseminated intravascular coagulation and coagulopathy. Acute Med Surg. 2019;6:223–32. https://doi.org/10.1002/ams2.411.
Article PubMed PubMed Central Google Scholar
Dhainaut JF, Yan SB, Joyce DE, Pettilä V, Basson B, Brandt JT, et al. Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. J Thromb Haemost. 2004;2:1924–33. https://doi.org/10.1111/j.1538-7836.2004.00955.x.
Gando S, Iba T, Eguchi Y, et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria*. Crit Care Med. 2006;34:625. https://doi.org/10.1097/01.CCM.0000202209.42491.38.
Gando S, Saitoh D, Ishikura H, et al. A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis. Crit Care (Lond Engl). 2013;17:R297. https://doi.org/10.1186/cc13163.
Tanaka K, Takeba J, Matsumoto H, Ohshita M, Annen S, Moriyama N, et al. Anticoagulation therapy using rh-thrombomodulin and/or antithrombin III agent is associated with reduction in in-hospital mortality in septic disseminated intravascular coagulation: a nationwide registry study. Shock (Augusta Ga). 2019;51:713–7. https://doi.org/10.1097/SHK.0000000000001230.
Endo S, Shimazaki R, Antithrombin Gamma Study Group. An open-label, randomized, phase 3 study of the efficacy and safety of antithrombin gamma in patients with sepsis-induced disseminated intravascular coagulation syndrome. J Intensive Care. 2018;6:75. https://doi.org/10.1186/s40560-018-0339-z.
Jiang S, Ma J, Ye S, Meaney C, Moore TE, Pan S, et al. Associations among disseminated intravascular coagulation, thrombocytopenia cytokines/chemokines and genetic polymorphisms of toll-like receptor 2/4 in Chinese patients with sepsis. J Inflamm Res. 2022;15:1–15. https://doi.org/10.2147/JIR.S337559.
Gando S, Saitoh D, Ogura H, et al. Disseminated intravascular coagulation (DIC) diagnosed based on the Japanese Association for Acute Medicine criteria is a dependent continuum to overt DIC in patients with sepsis. Thromb Res. 2009;123:715–8. https://doi.org/10.1016/j.thromres.2008.07.006.
Article CAS PubMed Google Scholar
Kato T, Sakai T, Kato M, Hagihara M, Hasegawa T, Matsuura K, et al. Recombinant human soluble thrombomodulin administration improves sepsis-induced disseminated intravascular coagulation and mortality: a retrospective cohort study. Thromb J. 2013;11:3. https://doi.org/10.1186/1477-9560-11-3.
Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801–10. https://doi.org/10.1001/jama.2016.0287.
• Iba T, Helms J, Connors JM, Levy JH. The pathophysiology, diagnosis, and management of sepsis-associated disseminated intravascular coagulation. J Intensive Care. 2023;11:24. https://doi.org/10.1186/s40560-023-00672-5. This article provides a comprehensive guide on the underlying mechanisms, diagnosis, and management of sepsis-associated disseminated intravascular coagulation.
Iba T, Di Nisio M, Thachil J, Wada H, Asakura H, Sato K, et al. Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity. Crit Care Lond Engl. 2016;20:287. https://doi.org/10.1186/s13054-016-1468-1.
Iba T, Nisio MD, Levy JH, Kitamura N, Thachil J. New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. BMJ Open. 2017;7:e017046. https://doi.org/10.1136/bmjopen-2017-017046.
Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996:22:707–10. https://doi.org/10.1007/BF01709751.
Tanaka C, Tagami T, Kudo S, et al. Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: post hoc analysis of a nationwide multicenter observational study in Japan. Int J Hematol. 2021;114:164–71. https://doi.org/10.1007/s12185-021-03152-4.
Article PubMed PubMed Central Google Scholar
Vincent JL. Dear SIRS, I’m sorry to say that I don’t like you. Crit Care Med 1997:25:372–4.
Iba T, Arakawa M, Levy JH, Yamakawa K, Koami H, Hifumi T, et al. Sepsis-induced coagulopathy and Japanese Association for Acute Medicine DIC in coagulopathic patients with decreased antithrombin and treated by antithrombin. Clin Appl Thromb. 2018;24:1020–6. https://doi.org/10.1177/1076029618770273.
Yamakawa K, Yoshimura J, Ito T, Hayakawa M, Hamasaki T, Fujimi S. External validation of the two newly proposed criteria for assessing coagulopathy in sepsis. Thromb Haemost. 2019;119:203–12. https://doi.org/10.1055/s-0038-1676610.
Iba T, Arakawa M, Di Nisio M, Gando S, Anan H, Sato K, et al. Newly proposed sepsis-induced coagulopathy precedes international society on thrombosis and haemostasis overt-disseminated intravascular coagulation and predicts high mortality. J Intensive Care Med. 2020;35:643–9. https://doi.org/10.1177/0885066618773679.
Ding R, Wang Z, Lin Y, Liu B, Zhang Z, Ma X. Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0: a retrospective study. Blood Coagul Fibrinolysis. 2018;29:551–8. https://doi.org/10.1097/MBC.0000000000000755.
Iba T, Levy JH, Yamakawa K, Thachil J, Warkentin TE, Levi M. Proposal of a two-step process for the diagnosis of sepsis-induced
Comments (0)