Synovial fluid alpha-defensins in Lyme arthritis—a useful marker

Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP (2005) Diagnosis of Lyme borreliosis. Clin Microbiol Rev 18(3):484–509. https://doi.org/10.1128/CMR.18.3.484-509.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn JK, Huang B, Bae EK et al (2013) The role of α-defensin-1 and related signal transduction mechanisms in the production of IL-6, IL-8 and MMPs in rheumatoid fibroblast-like synoviocytes. Rheumatology 52:1368–1376. https://doi.org/10.1093/rheumatology/ket147

Article  CAS  PubMed  Google Scholar 

Branda JA, Strle F, Strle K, Sikand N, Ferraro MJ, Steere AC (2013) Performance of United States serologic assays in the diagnosis of Lyme borreliosis acquired in Europe. Clin Infect Dis 57(3):333–340. https://doi.org/10.1093/cid/cit235

Article  CAS  PubMed  PubMed Central  Google Scholar 

Branda JA, Steere AC (2021) Laboratory diagnosis of lyme borreliosis. Clin Microbiol Rev 34(2):e00018-19. https://doi.org/10.1128/CMR.00018-19

Article  CAS  PubMed  PubMed Central  Google Scholar 

Branda JA, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder J, Steere AC, Witkowski J, Wong SJ, Schutzer SE (2018) Advances in serodiagnostic testing for Lyme disease are at hand. Clin Infect Dis 66(7):1133–9. https://doi.org/10.1093/cid/cix943

Article  CAS  PubMed  Google Scholar 

Bystroňová I, Kušnierová P, Walder P, Hlubek R, Rolová J, Stejskal D (2021) Přehled biomarkerů synoviální tekutiny u kloubních onemocnění. Klin Biochem Meta 29(50):11–18

Google Scholar 

Chan BY, Crawford AM, Kobes PH, Allen H, Leake RL, Hanrahan CJ, Mills MK (2020) Septic arthritis: an evidence based review of diagnosis and image-guided aspiration. AJR Am J Roentgenol 215(3):568–581. https://doi.org/10.2214/AJR.20.22773

Article  PubMed  Google Scholar 

Chang DJ, Leonard HS (2004) Guidelines for serologic testing for Lyme disease: the tests: they can be used to confirm, but not make, a clinical diagnosis. The Journal of Musculoskeletal Medicine 21(7), 365+. Gale Academic OneFile. https://link.gale.com/apps/doc/A120461625/AONE?u=anon~8293951&sid=googleScholar&xid=76fe3b08. Accessed 23 Aug. 2022

Corre C, Coiffier G, Le Goff B, Ferreyra M, Guennic X, Patrat-Delon S, Degeilh B, Albert JD, Tattevin P (2022) Lyme arthritis in Western Europe: a multicentre retrospective study. Eur J Clin Microbiol Infect Dis 41(1):21–27. https://doi.org/10.1007/s10096-021-04334-y

Article  CAS  PubMed  Google Scholar 

Dejmková H, Hulínska D, Tegzová D, Pavelka K, Gatterová J, Vavrík P (2002) Seronegative Lyme arthritis caused by Borrelia garinii. Clin Rheumatol 21:330–334. https://doi.org/10.1007/s100670200087

Article  PubMed  Google Scholar 

Dressler F, Whalen JA, Reinhardt BN, Steere AC (1993) Western blotting in the serodiagnosis of Lyme disease. J Infect Dis 167(2):392–400. https://doi.org/10.1093/infdis/167.2.392

Article  CAS  PubMed  Google Scholar 

Engstrom SM, Shoop E, Johnson RC (1995) Immunoblot interpretation criteria for serodiagnosis of early Lyme disease. J Clin Microbiol 33(2):419–27. https://doi.org/10.1128/jcm.33.2.419-427.1995

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frangiamore SJ, Gajewski ND, Saleh A, Farias-Kovac M, Barsoum WK, Higuera CA (2016) α-Defensin accuracy to diagnoseperiprosthetic joint infection—best available test? J Arthroplasty 31(2):456–60. https://doi.org/10.1016/j.arth.2015.09.035

Article  PubMed  Google Scholar 

Ganz T (2003) Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3(9):710–720. https://doi.org/10.1038/nri1180

Article  CAS  PubMed  Google Scholar 

Govil S, Capitle E, Lacqua A, Khianey R, Coyle PK, Schutzer SE (2023) Common neurologic features of Lyme disease that may present to a rheumatologist. Pathogens 12(4):576. https://doi.org/10.3390/pathogens12040576

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heymann WR, Ellis DL (2012) Borrelia burgdorferi infections in the United States. J Clin Aesthet Dermatol 5(8):18–28. PMID: 22916311

PubMed  PubMed Central  Google Scholar 

Klopfenstein T, Jaulhac B, Blanchon T, Hansmann Y, Chirouze C (2019) Épidémiologie de la borréliose de Lyme en France : entre incertitudes et certitudes [Epidemiology of Lyme borreliosis in France - both certainties and uncertainties]. Sante Publique S1(HS):51–63. https://doi.org/10.3917/spub.190.0051

Article  PubMed  Google Scholar 

Lehrer RI, Lu W (2012) α-Defensins in human innate immunity. Immunol Rev 245(1):84–112. https://doi.org/10.1111/j.1600-065X.2011.01082.x

Article  CAS  PubMed  Google Scholar 

Lochhead RB, Ordoñez D, Arvikar SL, Aversa JM, Oh LS, Heyworth B, Sadreyev R, Steere AC, Strle K (2019) Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells. Cell Microbiol 21(2):e12992. https://doi.org/10.1111/cmi.12992

Article  CAS  PubMed  PubMed Central  Google Scholar 

Melicherčík P, Klapková E, Kotaška K, Jahoda D, Landor I, Čeřovský V (2020) High-performance liquid chromatography as a novel method for the determination of α-defensins in synovial fluid for diagnosis of orthopedic infections. Diagnostics 10(1):33. https://doi.org/10.3390/diagnostics10010033

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parvizi J, Gehrke T (2014) Definition of periprosthetic joint infection. J Arthroplast. https://doi.org/10.1016/j.arth.2014.03.009

Article  Google Scholar 

Pujalte GG, Albano-Aluquin SA (2015) Differential diagnosis of polyarticular arthritis. Am Fam Physician 92(1):35–41. PMID: 26132125

PubMed  Google Scholar 

Reed KD (2002) Laboratory testing for Lyme disease: possibilities and practicalities. J Clin Microbiol 40(2):319–324. https://doi.org/10.1128/JCM.40.2.319-324.2002

Article  PubMed  PubMed Central  Google Scholar 

Salari P, Grassi M, Cinti B, Onori N, Gigante A (2020) Synovial fluid calprotectin for the preoperative diagnosis of chronic periprosthetic joint infection. J Arthroplasty 35(2):534–7. https://doi.org/10.1016/j.arth.2019.08.052

Article  PubMed  Google Scholar 

Slavov SN, Christova IS, Ferreira AR, Rodrigues ES, Bianquini ML, Hespanhol MR, Covas DT, Kashima S (2019) Serological evidence of Borrelia circulation among blood donors in the São Paulo state. Brazil Transfus Med 29(5):358–63. https://doi.org/10.1111/tme.12627

Article  CAS  PubMed  Google Scholar 

Steere AC (2019) Treatment of Lyme arthritis. J Rheumatol 46(8):871–873. https://doi.org/10.3899/jrheum.190320

Article  CAS  PubMed  Google Scholar 

Strnad M, Hönig V, Růžek D, Grubhoffer L, Rego ROM (2017) Europe-wide meta-analysis of Borrelia burgdorferi sensu lato prevalence in questing Ixodes ricinus ticks. Appl Environ Microbiol 83(15):e00609-e617. https://doi.org/10.1128/AEM.00609-17

Article  PubMed  PubMed Central  Google Scholar 

Strobino B, Steinhagen K, Meyer W, Scheper T, Saschenbrecker S, Schlumberger W, Stöcker W, Gaito A, Fallon BA (2018) A community study of Borrelia burgdorferi antibodies among individuals with prior Lyme disease in endemic areas. Healthcare (Basel) 6(2):69. https://doi.org/10.3390/healthcare6020069

Article  PubMed  Google Scholar 

Swan A, Amer H, Dieppe P (2002) The value of synovial fluid assays in the diagnosis of joint disease: a literature survey. Ann Rheum Dis 61(6):493–498. https://doi.org/10.1136/ard.61.6.493

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif